High-resolution 3D Bayesian image reconstruction using the microPET small-animal scanner

1998 ◽  
Vol 43 (4) ◽  
pp. 1001-1013 ◽  
Author(s):  
Jinyi Qi ◽  
Richard M Leahy ◽  
Simon R Cherry ◽  
Arion Chatziioannou ◽  
Thomas H Farquhar
Keyword(s):  
High Resolution ◽  
Image Reconstruction ◽  
Small Animal ◽  
Bayesian Image Reconstruction

A GPU-accelerated fully 3D OSEM image reconstruction for a high-resolution small animal PET scanner using dual-ended readout detectors

2020 ◽  
Vol 65 (24) ◽  
pp. 245007 ◽  
Author(s):  
Tianyi Zeng ◽  
Juan Gao ◽  
Dongfang Gao ◽  
Zhonghua Kuang ◽  
Ziru Sang ◽  
...  
Keyword(s):  
High Resolution ◽  
Image Reconstruction ◽  
Small Animal ◽  
Small Animal Pet ◽  
Animal Pet

scholarly journals A FULLY THREE-DIMENSIONAL BAYESIAN IMAGE RECONSTRUCTION FOR SMALL ANIMAL PINHOLE SPECT

2004 ◽  
Vol 16 (04) ◽  
pp. 180-184
Author(s):  
P. C. HUANG ◽  
C. H. HSU ◽  
C. S. LIU ◽  
R. S. LIU
Keyword(s):  
Image Reconstruction ◽  
Small Animal Imaging ◽  
Three Dimensional ◽  
Small Animal ◽  
Pinhole Spect ◽  
Major Disadvantage ◽  
One Step ◽  
Phantom Studies ◽  
Bayesian Image Reconstruction ◽  
Low Sensitivity

This paper presents a fully 3D Bayesian image reconstruction and its localization properties of a pinhole SPECT for small animal imaging. Due to the unique geometric characteristics, pinhole SPECT for small animals can use existing clinical equipment to produce high resolution image results. However, low sensitivity is the major disadvantage of pinhole SPECT and leads to instability of iterative image reconstruction based on popular maximum likelihood expectation and maximization (MLEM). In this work, we describe a fully 3D system model of a pinhole SPECT combined with an image model based on medium root prior (MRP). Under the paradigm of Bayesian statistics, a modified EM algorithm with one-step late (OSL) is applied to reconstruct 3D SPECT images through maximum a posteriori (MAP) estimation. The experimental results of phantom studies indicate that the proposed 3D Bayesian image reconstruction can produce better edgepreserving image results and effectively suppress noises.

scholarly journals High-resolution dynamic oxygen-17 MR imaging of mouse brain with golden-ratio-based radial sampling and k-space-weighted image reconstruction

2017 ◽  
Vol 79 (1) ◽  
pp. 256-263 ◽  
Author(s):  
Yuchi Liu ◽  
Yifan Zhang ◽  
Chunying Wu ◽  
Junqing Zhu ◽  
Charlie Wang ◽  
...  
Keyword(s):  
High Resolution ◽  
Image Reconstruction ◽  
Mr Imaging ◽  
Mouse Brain ◽  
Golden Ratio ◽  
Weighted Image ◽  
Radial Sampling

scholarly journals In VivoVisualization of Heterogeneous Intratumoral Distribution of Hypoxia-Inducible Factor-1αActivity by the Fusion of High-Resolution SPECT and Morphological Imaging Tests

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Hirofumi Fujii ◽  
Masayuki Yamaguchi ◽  
Kazumasa Inoue ◽  
Yasuko Mutou ◽  
Masashi Ueda ◽  
...  
Keyword(s):  
High Resolution ◽  
Ex Vivo ◽  
Hypoxia Inducible Factor ◽  
Chimeric Protein ◽  
Small Animal ◽  
Ct Scanner ◽  
Heterogeneous Distribution ◽  
Fusion Images ◽  
Intratumoral Distribution

Purpose. We aimed to clearly visualize heterogeneous distribution of hypoxia-inducible factor 1α(HIF) activity in tumor tissuesin vivo.Methods. We synthesized of125I-IPOS, a125I labeled chimeric protein probe, that would visualize HIF activity. The biodistribution of125I-IPOS in FM3A tumor-bearing mice was evaluated. Then, the intratumoral localization of this probe was observed by autoradiography, and it was compared with histopathological findings. The distribution of125I-IPOS in tumors was imaged by a small animal SPECT/CT scanner. The obtainedin vivoSPECT-CT fusion images were compared withex vivoimages of excised tumors. Fusion imaging with MRI was also examined.Results.125I-IPOS well accumulated in FM3A tumors. The intratumoral distribution of125I-IPOS by autoradiography was quite heterogeneous, and it partially overlapped with that of pimonidazole. High-resolution SPECT-CT fusion images successfully demonstrated the heterogeneity of125I-IPOS distribution inside tumors. SPECT-MRI fusion images could give more detailed information about the intratumoral distribution of125I-IPOS.Conclusion. High-resolution SPECT images successfully demonstrated heterogeneous intratumoral distribution of125I-IPOS. SPECT-CT fusion images, more favorably SPECT-MRI fusion images, would be useful to understand the features of heterogeneous intratumoral expression of HIF activityin vivo.

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