Real-time monitoring of DNA hybridization and melting processes using a fiber optic sensor

2012 ◽  
Vol 23 (6) ◽  
pp. 065503 ◽  
Author(s):  
Filip Delport ◽  
Jeroen Pollet ◽  
Kris Janssen ◽  
Bert Verbruggen ◽  
Karel Knez ◽  
...  
2017 ◽  
Author(s):  
Ping Lu ◽  
Kevin Byerly ◽  
Michael Buric ◽  
Paul Zandhuis ◽  
Chenhu Sun ◽  
...  

2020 ◽  
Vol 10 (3) ◽  
pp. 1053
Author(s):  
Dimosthenis Spasopoulos ◽  
George Rattas ◽  
Archontis Kaisas ◽  
Thomas Dalagiannis ◽  
Ioannis D. Bassukas ◽  
...  

Cryosurgery/cryotherapy is a widely used, freezing–thawing technique for the renewal or destruction of pathological tissues by applying localized rapid cooling; however, it still relies on the subjective “expert knowledge” of the physicians without, up to now, real-time monitoring of the treatment. This work focused on assessing the depth of freezing using optical transmission and backscattering measurements from frozen/unfrozen porcine ex-vivo skin samples. An optical fiber-array sensor was subsequently developed to determine the depth of freezing and the associated kill zone during freeze–thawing cycles with sub-millimeter accuracy within the skin tissue.


1997 ◽  
Vol 31 (1) ◽  
pp. 87-102 ◽  
Author(s):  
Y. M. Liu ◽  
C. Ganesh ◽  
J. P. H. Steele ◽  
J. E. Jones

2015 ◽  
Vol 31 (3) ◽  
pp. 177-183 ◽  
Author(s):  
Takuya OKAZAKI ◽  
Kenichiro IMAI ◽  
Shin Y. TAN ◽  
Yun T. YONG ◽  
Faidz A. RAHMAN ◽  
...  

Sensor Review ◽  
2021 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Adel Abdallah ◽  
Mohamed M. Fouad ◽  
Hesham N. Ahmed

Purpose The purpose of this paper is to introduce a novel intensity-modulated fiber optic sensor for real-time intrusion detection using a fiber-optic microbend sensor and an optical time-domain reflectometer (OTDR). Design/methodology/approach The proposed system is tested using different scenarios using person/car as intruders. Experiments are conducted in the lab and in the field. In the beginning, the OTDR trace is obtained and recorded as a reference signal without intrusion events. The second step is to capture the OTDR trace with intrusion events in one or multiple sectors. This measured signal is then compared to the reference signal and processed by matrix laboratory to determine the intruded sector. Information of the intrusion is displayed on an interactive screen implemented by Visual basic. The deformer is designed and implemented using SOLIDWORKS three-dimensional computer aided design Software. Findings The system is tested for intrusions by performing two experiments. The first experiment is performed for both persons (>50 kg) in the lab and cars in an open field with a car moving at 60 km/h using two optical fiber sectors of lengths 200 and 500 m. For test purposes, the deformer length used in the experiment is 2 m. The used signal processing technique in the first experiment has some limitations and its accuracy is 70% after measuring and recording 100 observations. To overcome these limitations, a second experiment with another technique of signal processing is performed. Research limitations/implications The system can perfectly display consecutive intrusions of the sectors, but in case of simultaneous intrusions of different sectors, which is difficult to take place in real situations, there will be the ambiguity of the number of intruders and the intruded sector. This will be addressed in future work. Suitable and stable laser power is required to get a suitable level of backscattered power. Optimization of the deformer is required to enhance the sensitivity and reliability of the sensor. Practical implications The proposed work enables us to benefit from the ease of implementation and the reduced cost of the intensity-modulated fiber optic sensors because it overcomes the constraints that prevent using the intensity-modulated fiber optic sensors for intrusion detection. Originality/value The proposed system is the first time long-range intensity-modulated fiber optic sensor for intrusion detection.


The Analyst ◽  
2017 ◽  
Vol 142 (11) ◽  
pp. 1974-1981 ◽  
Author(s):  
Savannah Kaye ◽  
Zheng Zeng ◽  
Mollye Sanders ◽  
Krishnan Chittur ◽  
Paula M. Koelle ◽  
...  

A miniaturized, robust, localized surface plasmon resonance (LSPR)–coupled fiber-optic (FO) nanoprobe providing an integrated and portable solution for detection of DNA hybridization and measurement of DNA concentrations has been demonstrated.


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