Observation of intermolecular double-quantum coherence signal dips in nuclear magnetic resonance

2011 ◽  
Vol 20 (10) ◽  
pp. 103301
Author(s):  
Gui-Ping Shen ◽  
Cong-Bo Cai ◽  
Shu-Hui Cai ◽  
Zhong Chen
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
Quantum Coherence ◽  
Double Quantum ◽  
Intermolecular Double Quantum Coherence ◽  
Nuclear Magnetic

Suppression of sodium nuclear magnetic resonance double‐quantum coherence by chemical shift and relaxation reagents

1992 ◽  
Vol 97 (12) ◽  
pp. 8934-8940 ◽  
Author(s):  
Robert B. Hutchison ◽  
James J. A. Huntley ◽  
Haoran Jin ◽  
Joseph I. Shapiro
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
Chemical Shift ◽  
Quantum Coherence ◽  
Double Quantum ◽  
Nuclear Magnetic

scholarly journals N-[7-Chloro-4-[4-(phenoxymethyl)-1H-1,2,3-triazol-1-yl] quinoline]-acetamide

Molbank ◽  
10.3390/m1213 ◽  
2021 ◽  
Vol 2021 (2) ◽  
pp. M1213
Author(s):  
Paolo Coghi ◽  
Jerome P. L. Ng ◽  
Ali Adnan Nasim ◽  
Vincent Kam Wai Wong
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
Quantum Coherence ◽  
Biologically Active ◽  
Proton Nuclear Magnetic Resonance ◽  
Dipolar Cycloaddition ◽  
Heteronuclear Single Quantum Coherence ◽  
Pharmacokinetic Properties ◽  
Nuclear Magnetic

The 1,2,3-triazole is a well-known biologically active pharmacophore constructed by the copper-catalyzed azide–alkyne cycloaddition. We herein reported the synthesis of 4-amino-7-chloro-based [1,2,3]-triazole hybrids via Cu(I)-catalyzed Huisgen 1,3-dipolar cycloaddition of 4-azido-7-chloroquinoline with an alkyne derivative of acetaminophen. The compound was fully characterized by Fourier-transform infrared (FTIR), proton nuclear magnetic resonance (1H-NMR), carbon-13 nuclear magnetic resonance (13C-NMR), heteronuclear single quantum coherence (HSQC), ultraviolet (UV) and high-resolution mass spectroscopies (HRMS). This compound was screened in vitro with different normal and cancer cell lines. The drug likeness of the compound was also investigated by predicting its pharmacokinetic properties.

Dynamic Inhomogeneity in Homogeneous Polymer Melts

Soft Matter ◽  
2021 ◽  
Author(s):  
Lin-Lin Chu ◽  
Kaipin Xu ◽  
Robert Graf ◽  
Zhichao Yan ◽  
Junfang Li ◽  
...  
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
Ethylene Oxide ◽  
Polymer Melts ◽  
Double Quantum ◽  
Chain Entanglement ◽  
Poly Ethylene Oxide ◽  
Poly Ethylene ◽  
Nuclear Magnetic

Chain entanglement behaviors were studied by 1H Hahn echo nuclear magnetic resonance (NMR) and 1H double-quantum (DQ) NMR experiments. Poly(ethylene oxide) (PEO) was chosen to investigate the chain entanglement behaviors....

scholarly journals Synthesis and characterization of new impurities in obeticholic acid

2019 ◽  
Vol 43 (11-12) ◽  
pp. 522-530
Author(s):  
Wei-Dong Feng ◽  
Song-Ming Zhuo ◽  
Fu-Li Zhang
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
Quantum Coherence ◽  
High Resolution Mass Spectrometry ◽  
Multiple Bond ◽  
Protecting Group ◽  
Obeticholic Acid ◽  
Overhauser Effect ◽  
Nuclear Magnetic

Novel and efficient synthetic strategies are developed for the first synthesis of two new impurities found in obeticholic acid. The synthetic routes to the impurities are designed without column purification using 4-nitrobenzoyl chloride as a selective protecting group. The impurities, which are obtained in good yields and high purity, are identified and characterized using high-resolution mass spectrometry, Fourier transform infrared, one-dimensional nuclear magnetic resonance (1H, 13C, distortionless enhancement by polarization transfer), and two-dimensional nuclear magnetic resonance (Correlated Spectroscopy, heteronuclear single quantum coherence, heteronuclear multiple bond correlation, and rotating-frame Overhauser effect spectroscopy) techniques.

Comparison of 1-D and 2-D NMR techniques for screening earthworm responses to sub-lethal endosulfan exposure

2010 ◽  
Vol 7 (6) ◽  
pp. 524 ◽  
Author(s):  
Jimmy Yuk ◽  
Jennifer R. McKelvie ◽  
Myrna J. Simpson ◽  
Manfred Spraul ◽  
André J. Simpson
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
Organochlorine Pesticide ◽  
Environmental Exposure ◽  
Quantum Coherence ◽  
Metabolic Response ◽  
Powerful Approach ◽  
Nmr Techniques ◽  
And Control ◽  
Nuclear Magnetic

Environmental context The application of metabolomics from an environmental perspective depends on the analytical ability to discriminate minute changes in the organism resulting from exposure. In this study, 1-D and 2-D Nuclear Magnetic Resonance (NMR) experiments were examined to characterise the earthworm’s metabolic response to an organochlorine pesticide. 2-D NMR showed considerable improvement in discriminating exposed worms from controls and in identifying the metabolites responsible. This study demonstrates the potential of 2-D NMR in understanding subtle biochemical responses resulting from environmental exposure. Abstract Nuclear Magnetic Resonance (NMR) based metabolomics is a powerful approach to monitoring an organism’s metabolic response to environmental exposure. However, the discrimination between exposed and control groups, depends largely on the NMR technique chosen. Here, three 1-D NMR and three 2-D NMR techniques were investigated for their ability to discriminate between control earthworms (Eisenia fetida) and those exposed to a sub-lethal concentration of a commonly occurring organochlorine pesticide, endosulfan. Partial least-squares discriminant analysis found 1H–13C Heteronuclear Single Quantum Coherence (HSQC) spectroscopy to have the highest discrimination with a MANOVA value (degree of separation) three orders lower than any of the 1-D and 2-D NMR techniques. HSQC spectroscopy identified alanine, leucine, lysine, glutamate, glucose and maltose as the major metabolites of exposure to endosulfan, more than all the other techniques combined. HSQC spectroscopy in combination with a shorter 1-D experiment may prove to be an effective tool for the discrimination and identification of significant metabolites in organisms under environmental stress.

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