scholarly journals Automatic classification of idiopathic Parkinson's disease and atypical parkinsonian syndromes combining [11C]raclopride PET uptake and MRI grey matter morphometry

2021 ◽  
Author(s):  
Ricardo Martins ◽  
Francisco Paulo Marques Oliveira ◽  
Fradique Moreira ◽  
Ana Paula Moreira ◽  
Antero Abrunhosa ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Grey Matter ◽  
Automatic Classification ◽  
Idiopathic Parkinson’S Disease ◽  
Parkinsonian Syndromes ◽  
Idiopathic Parkinson's Disease

scholarly journals Environment, Genetics and Idiopathic Parkinson's Disease

1991 ◽  
Vol 18 (1) ◽  
pp. 70-76 ◽  
Author(s):  
Judes Poirier ◽  
Sandra Kogan ◽  
Serge Gauthier
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Current Knowledge ◽  
Idiopathic Parkinson’S Disease ◽  
Parkinsonian Syndromes ◽  
Idiopathic Parkinson's Disease ◽  
Radical Generation ◽  
Review Current ◽  
Aging Factor

ABSTRACT:Since Idiopathic Parkinson's disease (IPD) was first described more than 170 years ago, there have been major advances in the understanding of the etiology of the disease as well as in its treatment. This article will review current knowledge concerning the role of the environment, genetic hypotheses and the aging factor in the etiology of IPD and proposes a complex interaction involving all these factors. Hypotheses regarding mitochondrial inhibition and free radical generation in IPD are discussed in relation to the mechanism of action of neurotoxins known to produce parkinsonian syndromes.

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