Transcranial Sonography for the Discrimination of Idiopathic Parkinson’s Disease from the Atypical Parkinsonian Syndromes

2010 ◽  
pp. 121-146 ◽  
Author(s):  
Angela E.P. Bouwmans ◽  
Annemarie M.M. Vlaar ◽  
Karin Srulijes ◽  
Werner H. Mess ◽  
W.E.J. Weber
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Transcranial Sonography ◽  
Idiopathic Parkinson’S Disease ◽  
Parkinsonian Syndromes ◽  
Idiopathic Parkinson's Disease

scholarly journals Transcranial sonography in Parkinson's disease

2012 ◽  
Vol 10 (2) ◽  
pp. 242-246 ◽  
Author(s):  
Edson Bor-Seng-Shu ◽  
José Luiz Pedroso ◽  
Daniel Ciampi de Andrade ◽  
Orlando Graziani Povoas Barsottini ◽  
Luiz Augusto Franco de Andrade ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Differential Diagnosis ◽  
Substantia Nigra ◽  
Low Cost ◽  
Transcranial Sonography ◽  
Nigrostriatal Pathway ◽  
Non Invasive ◽  
Parkinsonian Syndromes ◽  
Idiopathic Parkinson's Disease

Transcranial sonography has become a useful tool in the differential diagnosis of parkinsonian syndromes. This is a non-invasive, low cost procedure. The main finding on transcranial sonography in patients with idiopathic Parkinson's disease is an increased echogenicity of the mesencephalic substantia nigra region. This hyperechogenicity is present in more than 90% of cases, and reflects a dysfunction in the dopaminergic nigrostriatal pathway. This study discussed how the hyperechogenicity of the substantia nigra may facilitate the differential diagnosis of parkinsonian syndromes.

scholarly journals Environment, Genetics and Idiopathic Parkinson's Disease

1991 ◽  
Vol 18 (1) ◽  
pp. 70-76 ◽  
Author(s):  
Judes Poirier ◽  
Sandra Kogan ◽  
Serge Gauthier
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Current Knowledge ◽  
Idiopathic Parkinson’S Disease ◽  
Parkinsonian Syndromes ◽  
Idiopathic Parkinson's Disease ◽  
Radical Generation ◽  
Review Current ◽  
Aging Factor

ABSTRACT:Since Idiopathic Parkinson's disease (IPD) was first described more than 170 years ago, there have been major advances in the understanding of the etiology of the disease as well as in its treatment. This article will review current knowledge concerning the role of the environment, genetic hypotheses and the aging factor in the etiology of IPD and proposes a complex interaction involving all these factors. Hypotheses regarding mitochondrial inhibition and free radical generation in IPD are discussed in relation to the mechanism of action of neurotoxins known to produce parkinsonian syndromes.

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