Targeting of Hepatitis C Virus Core Protein for MHC I or MHC II Presentation Does Not Enhance Induction of Immune Responses to DNA Vaccination

1999 ◽  
Vol 18 (8) ◽  
pp. 611-621 ◽  
Author(s):  
O. Vidalin ◽  
E. Tanaka ◽  
U. Spengler ◽  
C. Trepo ◽  
G. Inchauspe
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Immune Responses ◽  
Core Protein ◽  
Dna Vaccination ◽  
Mhc I ◽  
Mhc Ii ◽  
Virus Core

scholarly journals Immune responses to plasmid DNA encoding the hepatitis C virus core protein.

1995 ◽  
Vol 69 (9) ◽  
pp. 5859-5863 ◽  
Author(s):  
L M Lagging ◽  
K Meyer ◽  
D Hoft ◽  
M Houghton ◽  
R B Belshe ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Immune Responses ◽  
Plasmid Dna ◽  
Core Protein ◽  
Dna Encoding ◽  
Virus Core

scholarly journals The Wild-Type Hepatitis C Virus Core Inhibits Initiation of Antigen-Specific T- and B-Cell Immune Responses in BALB/c Mice

2010 ◽  
Vol 17 (7) ◽  
pp. 1139-1147 ◽  
Author(s):  
Wenbo Zhu ◽  
Yanzi Chang ◽  
Chunchen Wu ◽  
Qingxia Han ◽  
Rongjuan Pei ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Immune Responses ◽  
Core Protein ◽  
Repeated Administration ◽  
Wild Type ◽  
Virus Core ◽  
Hcv Core Protein ◽  
Core Proteins ◽  
Potential Applications

ABSTRACT In this study, the effects of wild-type and deletion mutant hepatitis C virus (HCV) core proteins on the induction of immune responses in BALB/c mice were assessed. p2HA-C145-S23, encoding a core protein with the C-terminal 46 amino acids truncated, significantly produced stronger antibody and cellular responses than p2HA-C191-S23. The induction of immune responses by p2HA-C145-S23 was dose dependent. However, increasing the doses or repeated administration did not enhance immune responses by the wild-type core protein. In addition, p2HA-C191-S23 was apparently able to interfere with the priming of specific immune responses by p2HA-C145-S23 when the two were coadministered. These results demonstrated that the wild-type HCV core protein itself could inhibit the priming of immune responses in the course of a DNA vaccination, whereas the truncated HCV core protein could provide potential applications for the development of DNA- and peptide-based HCV vaccines.

Biosynthesis and biochemical properties of the hepatitis C virus core protein.

1994 ◽  
Vol 68 (6) ◽  
pp. 3631-3641 ◽  
Author(s):  
E Santolini ◽  
G Migliaccio ◽  
N La Monica
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Core Protein ◽  
Biochemical Properties ◽  
Virus Core

Truncated hepatitis C virus core protein encoded in hepatocellular carcinomas

2004 ◽  
Author(s):  
Rin Yamaguchi ◽  
Seiya Momosaki ◽  
Guang Gao ◽  
Chu Hsia ◽  
Masamichi Kojiro ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Core Protein ◽  
Virus Core ◽  
Hepatocellular Carcinomas

Genetic control of the murine humoral response to distinct epitopes of hepatitis C virus core protein

1995 ◽  
Vol 2 (1) ◽  
pp. 9-17 ◽  
Author(s):  
Z. Chen ◽  
I. Berkower ◽  
R. Y.-H. Wang ◽  
W.-M. Ching ◽  
H. J. Alter ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Genetic Control ◽  
Core Protein ◽  
Humoral Response ◽  
Virus Core

Titration of antibody against hepatitis C virus core protein and its clinical utility

1993 ◽  
Vol 18 (1) ◽  
pp. 138-139 ◽  
Author(s):  
Yuko Taura ◽  
Shigetoshi Fujiyama ◽  
Shin-ichi Kawano ◽  
Shinjiro Sato ◽  
Masafumi Goto ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Clinical Utility ◽  
Core Protein ◽  
Virus Core
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