Familial Aggregation of Autoimmune Thyroiditis in First-Degree Relatives of Patients with Juvenile Autoimmune Thyroid Disease

Background: Autoimmune thyroid disease (AITD), a mutual organ specific autoimmune disorder is seen mostly in women between 30-50 years of age. The rationale behind the study is to determine increased incidences of auto immune thyroiditis. The objective of the present study was to evaluate the incidence of autoimmune thyroiditis and thyroid dysfunction in healthy females with no previously known thyroid disease, in an urban area.Methods: The study was conducted on female volunteers with no known thyroid disease. 370 subjects among the hospital’s medical and administration personnel were recruited. All underwent thyroid ultrasound (US) and thyroid anti-peroxidase (TPOAb) and anti-thyroglobulin (TgAb) antibodies were measured. Hypoechogenicity and thyroid volume were determined by sonography.Results: the incidence of autoimmune thyroiditis was 23.2% and 20-30 years were most commonly affected (P = 0.008); when including cases of atrophic thyroid, the frequency decreased to 14.7%.Conclusions: The frequency of autoimmune thyroiditis is clearly elevated in the studied population. Further studies are necessary in order to define the increased incidence of autoimmune thyroid disease.

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Concurrent Celiac Disease, Idiopathic Thrombocytopenic Purpura and Autoimmune Thyroiditis: A Case Report

Clinical and Applied Thrombosis/Hemostasis ◽

10.1177/1076029610378502 ◽

2010 ◽

Vol 17 (6) ◽

pp. E13-E16 ◽

Cited By ~ 8

Author(s):

Murat Dogan ◽

Ertan Sal ◽

Sinan Akbayram ◽

Erdal Peker ◽

Yasar Cesur ◽

...

Keyword(s):

Immune Response ◽

Celiac Disease ◽

Idiopathic Thrombocytopenic Purpura ◽

Autoimmune Thyroiditis ◽

Thyroid Disease ◽

Autoimmune Thyroid Disease ◽

Thrombocytopenic Purpura ◽

Autoimmune Thyroid ◽

Acute Itp ◽

Current Report

Celiac disease (CD) is a disease of the small intestine caused by an immune response to ingested gluten. Idiopathic thrombocytopenic purpura (ITP) is a common acquired bleeding disorder of childhood. It may follow a viral infection or immunization and is caused by an inappropriate response of the immune system. Autoimmune thyroiditis (AT) is a disease that occurs due to autoimmune mechanisms. Celiac disease associated with autoimmune thyroid disease is well known, but the association of CD, autoimmune thyroid disease, and ITP has been reported very rarely in the literature. In the current report, we have presented a case with CD, AT, and acute ITP, because this association is rarely seen, and to emphasize that CD and AT should be kept in mind in patients with ITP.

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Besondere Manifestationsformen der Autoimmunthyreopathie

Praxis ◽

10.1024/0369-8394.91.27.1151 ◽

2002 ◽

Vol 91 (27) ◽

pp. 1151-1160

Author(s):

Fajfr ◽

Müller

Keyword(s):

Thyroid Disease ◽

Autoimmune Thyroid Disease ◽

Chromosome 6 ◽

Autoimmune Thyroid

Les maladies thyroïdiennes auto-immunes ou immunes (autoimmune thyroid disease, AITD) sont relativement fréquentes. Le terme de AITD comprend les thyréodites euthyroidiennes ou hypothyroïdiennes de Hashimoto avec ou sans goitre, les hyperthyroïdies classiques de Basedow et leurs variantes nettement plus rares euthyroïdiennes ou hypothyroïdiennes. Aucune des nombreuses classifications des AITD n'a pu s'imposer sur le plan international. La pathogénèse de toutes les formes d'AITD comprend une perturbation de la tolérance immune chez les individus prédisposés génétiquement (séquence HLA-DQAI*0501 sur le bras court du chromosome 6) qui provoque un processus auto-immun contre la glande thyroïdienne. Ces processus sont soit destructeurs ou inhibiteurs, soit stimulateurs, ce qui permet d'expliquer les formes très différentes de AITD. Dans de cas rares, ces processus peuvent se contrebalancer («balance hypotheseis»). Les anticorps anti-récepteurs TPO et TSH (TRAK) ont une place particulière dans le diagnostic des AITD. Les dosages de routine utilisent pour la mesure des TRAK des récepteurs qui ne peuvent pas différencier entre les anticorps stimulants ou bloquants contre les récepteurs TSH. C'est, entre autre pour ces raisons, que les résultats d'anticorps positifs ne sont utilisables qu'en connaissance de la clinique et / ou des paramètres de la fonction thyroïdienne. Ce travail présente quatre patients avec des formes plus complexes d'AITD et résume les connaissances actuelles.

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