Biological sex as a critical variable in CD4+ effector T cell function in preclinical models of multiple sclerosis.

2021 ◽  
Author(s):  
Muhammad Umair ◽  
Mohamed Reda Fazazi ◽  
Manu Rangachari
Keyword(s):  
Multiple Sclerosis ◽  
T Cell ◽  
Cell Function ◽  
Preclinical Models ◽  
Critical Variable ◽  
Effector T Cell ◽  
Biological Sex ◽  
T Cell Function

scholarly journals Enhancing immunotherapy of STING agonist for lymphoma in preclinical models

2018 ◽  
Vol 2 (17) ◽  
pp. 2230-2241 ◽  
Author(s):  
Adrienne Sallets ◽  
Sophie Robinson ◽  
Adel Kardosh ◽  
Ronald Levy
Keyword(s):  
T Cell ◽  
Cell Function ◽  
Preclinical Models ◽  
Cytotoxic Property ◽  
T Cell Function ◽  
Key Points

Key Points The immunotherapeutic property of STING agonists is more potent to clear lymphoma than its cytotoxic property. In situ vaccination with STING agonist can be enhanced by agents that improve APC or T-cell function such as anti-GITR and anti-PD-1.

FoxP3+Regulatory T Cells Suppress Effector T-Cell Function at Pathologic Site in Miliary Tuberculosis

2009 ◽  
Vol 179 (11) ◽  
pp. 1061-1070 ◽  
Author(s):  
Prabhat K. Sharma ◽  
Pradip K. Saha ◽  
Amar Singh ◽  
Surendra K. Sharma ◽  
Balaram Ghosh ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Regulatory T Cells ◽  
Cell Function ◽  
Miliary Tuberculosis ◽  
Effector T Cell ◽  
T Cell Function

Multiple sclerosis associated genetic variants ofCD226impair regulatory T cell function

Brain ◽  
2015 ◽  
Vol 138 (11) ◽  
pp. 3263-3274 ◽  
Author(s):  
Melanie Piédavent-Salomon ◽  
Anne Willing ◽  
Jan Broder Engler ◽  
Karin Steinbach ◽  
Simone Bauer ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
T Cell ◽  
Regulatory T Cell ◽  
Genetic Variants ◽  
Cell Function ◽  
T Cell Function

scholarly journals GENDER SPECIFIC INFLUENCES ON EFFECTOR T-CELL FUNCTION AND PROLIFERATION: 2-METHOXYESTRADIOL MODULATES CELLULAR REJECTION

2014 ◽  
Vol 30 (10) ◽  
pp. S251
Author(s):  
J.G. Luc ◽  
J.Y. Zhao ◽  
E.D. Michelakis ◽  
D.H. Freed ◽  
J. Nagendran
Keyword(s):  
T Cell ◽  
Cell Function ◽  
Effector T Cell ◽  
T Cell Function ◽  
Gender Specific ◽  
Cellular Rejection

Lower receptor avidity required for thymic clonal deletion than for effector T-cell function

Nature ◽  
1991 ◽  
Vol 351 (6326) ◽  
pp. 482-485 ◽  
Author(s):  
Hanspeter Pircher ◽  
Urs Hoffmann Rohrer ◽  
Demetrius Moskophidis ◽  
Rolf M. Zinkernagel ◽  
Hans Hengartner
Keyword(s):  
T Cell ◽  
Cell Function ◽  
Clonal Deletion ◽  
Effector T Cell ◽  
T Cell Function

scholarly journals Antigen-Specific Inhibition of Effector T Cell Function in Humans after Injection of Immature Dendritic Cells

2001 ◽  
Vol 193 (2) ◽  
pp. 233-238 ◽  
Author(s):  
Madhav V. Dhodapkar ◽  
Ralph M. Steinman ◽  
Joseph Krasovsky ◽  
Christian Munz ◽  
Nina Bhardwaj
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
T Cell ◽  
Cell Function ◽  
Cd8 T Cell ◽  
Specific Inhibition ◽  
Killer Activity ◽  
Effector T Cell ◽  
T Cell Function ◽  
Cell Immunity

Immunostimulatory properties of dendritic cells (DCs) are linked to their maturation state. Injection of mature DCs rapidly enhances antigen-specific CD4+ and CD8+ T cell immunity in humans. Here we describe the immune response to a single injection of immature DCs pulsed with influenza matrix peptide (MP) and keyhole limpet hemocyanin (KLH) in two healthy subjects. In contrast to prior findings using mature DCs, injection of immature DCs in both subjects led to the specific inhibition of MP-specific CD8+ T cell effector function in freshly isolated T cells and the appearance of MP-specific interleukin 10–producing cells. When pre- and postimmunization T cells were boosted in culture, there were greater numbers of MP-specific major histocompatibility complex tetramer-binding cells after immunization, but these had reduced interferon γ production and lacked killer activity. These data demonstrate the feasibility of antigen-specific inhibition of effector T cell function in vivo in humans and urge caution with the use of immature DCs when trying to enhance tumor or microbial immunity.

Consequences of Exposure to Ionizing Radiation for Effector T Cell Function In Vivo

1989 ◽  
Vol 2 (2) ◽  
pp. 69-78 ◽  
Author(s):  
B.T. ROUSE ◽  
D. HARTLEY ◽  
P.C. DOHERTY
Keyword(s):  
T Cell ◽  
Ionizing Radiation ◽  
Cell Function ◽  
Effector T Cell ◽  
T Cell Function
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