The Efficacy of Mini-Gastric Bypass Surgery in Diabetic and Prediabetic Obese Patients

Author(s):  
Kerim Guzel
2014 ◽  
Author(s):  
Dragan Micic ◽  
Snezana Polovina ◽  
Danka Jeremic ◽  
Dusan Micic ◽  
Mirjana Sumarac-Dumanovic

2012 ◽  
Vol 8 (6) ◽  
pp. 770-776 ◽  
Author(s):  
Joaquin Ortega ◽  
Regina Fernandez-Canet ◽  
Sagrario Álvarez-Valdeita ◽  
Norberto Cassinello ◽  
Maria Jose Baguena-Puigcerver

2015 ◽  
Vol 228 (1) ◽  
pp. 13-23 ◽  
Author(s):  
Xinrong Zhou ◽  
Bangguo Qian ◽  
Ning Ji ◽  
Conghui Lui ◽  
Zhiyuan Liu ◽  
...  

Gastric bypass surgery produces clear antidiabetic effects in a substantial proportion of morbidly obese patients. In view of the recent trend away from ‘bariatric’ surgery and toward ‘metabolic’ surgery, it is important to elucidate the enhancing effect of bypass surgery on pancreatic β-cell mass, which is related to diabetes remission in non-obese patients. We investigated the effects of gastric bypass surgery on glycemic control and other pancreatic changes in a spontaneous non-obese type 2 diabetes Goto-Kakizaki rat model. Significant improvements in postprandial hyperglycemia and plasma c-peptide level were observed when glucose was administered orally post-surgery. Other important events observed after surgery were enhanced first phase insulin secretion in a in site pancreatic perfusion experiment, pancreatic hyperplasia, improved islet structure (revealed by immunohistochemical analysis), striking increase in β-cell mass, slight increase in ratio of β-cell area to total pancreas area, and increased number of small islets closely related to exocrine ducts. No notable changes were observed in ratio of β-cell to non-β endocrine cell area, β-cell apoptosis, or β-cell proliferation. These findings demonstrate that gastric bypass surgery in this rat model increases endocrine cells and pancreatic hyperplasia, and reflect the important role of the gastrointestinal system in regulation of metabolism.


2017 ◽  
Vol 32 (suppl_3) ◽  
pp. iii432-iii432
Author(s):  
Thomas Ernandez ◽  
Catherine Stoermann-Chopard ◽  
Minoa Jung ◽  
William Robertson ◽  
Pierre-Yves Martin ◽  
...  

2019 ◽  
Vol 14 (4) ◽  
pp. 243-257
Author(s):  
Tummas Justinussen ◽  
Sten Madsbad ◽  
Jens Juul Holst ◽  
Kirstine Nyvold Bojsen-Møller

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