177Lu-EDTMP for Metastatic Bone Pain Palliation: A Systematic Review and Meta-analysis

2020 ◽  
Author(s):  
Emran Askari ◽  
Sara Harsini ◽  
Nasim Vahidfar ◽  
Ghasemali Divband ◽  
Ramin Sadeghi
Keyword(s):  
Systematic Review ◽  
Bone Pain ◽  
Meta Analysis ◽  
Pain Palliation ◽  
Bone Pain Palliation ◽  
Metastatic Bone Pain

Metastatic bone pain palliation with 89‐Sr and 186‐Re‐HEDP in breast cancer patients

2001 ◽  
Vol 66 (2) ◽  
pp. 101-109 ◽  
Author(s):  
Rosa Sciuto ◽  
Anna Festa ◽  
Rosella Pasqualoni ◽  
Alessandro Semprebene ◽  
Sandra Rea ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Bone Pain ◽  
Pain Palliation ◽  
Breast Cancer Patients ◽  
Bone Pain Palliation ◽  
Metastatic Bone Pain

scholarly journals Targeted Palliative Radionuclide Therapy for Metastatic Bone Pain

2020 ◽  
Vol 9 (8) ◽  
pp. 2622 ◽  
Author(s):  
Reyhaneh Manafi-Farid ◽  
Fardad Masoumi ◽  
Ghasemali Divband ◽  
Bahare Saidi ◽  
Bahar Ataeinia ◽  
...  
Keyword(s):  
Radionuclide Therapy ◽  
Bone Pain ◽  
Response Rate ◽  
Pain Palliation ◽  
Simultaneous Treatment ◽  
Bone Pain Palliation ◽  
Wide Range ◽  
Metastatic Bone Pain ◽  
Multiple Bone Metastases

Bone metastasis develops in multiple malignancies with a wide range of incidence. The presence of multiple bone metastases, leading to a multitude of complications and poorer prognosis. The corresponding refractory bone pain is still a challenging issue managed through multidisciplinary approaches to enhance the quality of life. Radiopharmaceuticals are mainly used in the latest courses of the disease. Bone-pain palliation with easy-to-administer radionuclides offers advantages, including simultaneous treatment of multiple metastatic foci, the repeatability and also the combination with other therapies. Several β¯- and α-emitters as well as pharmaceuticals, from the very first [89Sr]strontium-dichloride to recently introduced [223Ra]radium-dichloride, are investigated to identify an optimum agent. In addition, the combination of bone-seeking radiopharmaceuticals with chemotherapy or radiotherapy has been employed to enhance the outcome. Radiopharmaceuticals demonstrate an acceptable response rate in pain relief. Nevertheless, survival benefits have been documented in only a limited number of studies. In this review, we provide an overview of bone-seeking radiopharmaceuticals used for bone-pain palliation, their effectiveness and toxicity, as well as the results of the combination with other therapies. Bone-pain palliation with radiopharmaceuticals has been employed for eight decades. However, there are still new aspects yet to be established.

scholarly journals Metastatic Bone Pain Palliation using177Lu-Ethylenediaminetetramethylene Phosphonic Acid

2015 ◽  
Vol 14 (2) ◽  
pp. 109 ◽  
Author(s):  
Mehrosadat Alavi ◽  
Shapour Omidvari ◽  
Alireza Mehdizadeh ◽  
AmirR Jalilian ◽  
Ali Bahrami-Samani
Keyword(s):  
Phosphonic Acid ◽  
Bone Pain ◽  
Pain Palliation ◽  
Bone Pain Palliation ◽  
Metastatic Bone Pain

scholarly journals Retrospective evaluation of bone pain palliation after samarium-153-EDTMP therapy

2004 ◽  
Vol 59 (6) ◽  
pp. 321-328 ◽  
Author(s):  
Marcelo Tatit Sapienza ◽  
Carla Rachel Ono ◽  
Maria Inês Cury Guimarães ◽  
Tomoco Watanabe ◽  
Paulo Aguirre Costa ◽  
...  
Keyword(s):  
Bone Pain ◽  
Absorbed Dose ◽  
Pain Palliation ◽  
Weak Correlation ◽  
Pain Scores ◽  
Bone Pain Palliation ◽  
Pearson Coefficient ◽  
Subjective Scale ◽  
Metastatic Bone Pain

PURPOSE: The aim of this study was to evaluate the degree of metastatic bone pain palliation and medullar toxicity associated with samarium-153-EDTMP treatment. METHODS: Seventy-three patients with metastatic bone pain having previously undergone therapy with samarium-153-EDTMP (1 mCi/kg) were retrospectively evaluated. Routine follow-up included pain evaluation and blood counts for 2 months after treatment. Pain was evaluated using a subjective scale (from 0 to 10) before and for 8 weeks after the treatment. Blood counts were obtained before treatment and once a week for 2 months during follow-up. Dosimetry, based upon the urinary excretion of the isotope, was estimated in 41 individuals, and the resulting radiation absorbed doses were correlated with hematological data. RESULTS: Reduction in pain scores of 75% to 100% was obtained in 36 patients (49%), with a decrease of 50% to 75%, 25% to 50%, and 0% to 25% in, respectively, 20 (27%), 10 (14%), and 7 (10%) patients. There was no significant relationship between the pain response and location of the primary tumor (breast or prostate cancer). Mild to moderate myelosuppression was noted in 75.3% of patients, usually with hematological recovery at 8 weeks. The mean bone marrow dose was 347 ± 65 cGy, and only a weak correlation was found between absorbed dose and myelosuppression (Pearson coefficient = .4). CONCLUSIONS: Samarium-153-EDTMP is a valuable method for metastatic bone pain palliation. A mild to moderate and transitory myelosuppression is the main toxicity observed after samarium therapy, showing a weak correlation with dosimetric measures.

Samarium-153 EDTMP for metastatic bone pain palliation: The impact of europium impurities

2015 ◽  
Vol 31 (1) ◽  
pp. 104-107 ◽  
Author(s):  
J.A. Kalef-Ezra ◽  
S.T. Valakis ◽  
S. Pallada
Keyword(s):  
Bone Pain ◽  
Pain Palliation ◽  
Bone Pain Palliation ◽  
Metastatic Bone Pain ◽  
The Impact

186Re-1,4,8,11-tetraaza cyclotetradecyl-1,4,8,11-tetramethylene phosphonic acid: a novel agent for possible use in metastatic bone-pain palliation

2001 ◽  
Vol 28 (6) ◽  
pp. 709-717 ◽  
Author(s):  
Kanchan Kothari ◽  
Grace Samuel ◽  
Sharmila Banerjee ◽  
P.R Unni ◽  
H.D Sarma ◽  
...  
Keyword(s):  
Phosphonic Acid ◽  
Bone Pain ◽  
Pain Palliation ◽  
Bone Pain Palliation ◽  
Metastatic Bone Pain ◽  
Novel Agent

An electrochemical approach for removal of radionuclidic contaminants of Eu from 153 Sm for effective use in metastatic bone pain palliation

2018 ◽  
Vol 58 ◽  
pp. 8-19 ◽  
Author(s):  
Rubel Chakravarty ◽  
Sudipta Chakraborty ◽  
Mohammed Sahiralam Khan ◽  
Ramu Ram ◽  
Haladhar Dev Sarma ◽  
...  
Keyword(s):  
Bone Pain ◽  
Pain Palliation ◽  
Bone Pain Palliation ◽  
Electrochemical Approach ◽  
Metastatic Bone Pain ◽  
Effective Use
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