Patients' Psychological and Emotional Responses After a Diagnosis of Indeterminate Thyroid Nodule Cytology or Papillary Thyroid Cancer

The rate of nodular goiter in children ranges from 0.05 to 5.1%; in this case, the risk of thyroid cancer in childhood amounts to 3―70% of all cases of thyroid pathology. Therefore, the main issue is the differential diagnosis of a nosological variant of a thyroid nodule, which defines the optimal therapeutic tactics for a particular patient. The risk of malignancy is traditionally believed to be low in the case of decompensated functional autonomy of a thyroid nodule; therefore, the need for fine needle aspiration biopsy (FNAB) followed by cytomorphological analysis of the aspirate is avoided in most cases. The presented clinical case demonstrates papillary cancer in an adolescent with a toxic single nodular goiter. A thyroid ultrasound examination revealed a nodular lesion in the boy. An increase in the thyroid size and thyrotoxicosis manifestation occurred 3 years later. A cytomorphological study identified follicular neoplasia; scintigraphy revealed a hot nodule. Surgical treatment was planned. Antithyroid therapy was prescribed to prepare for surgery. After compensation of thyrotoxicosis, hemithyroidectomy was performed. A histological examination diagnosed papillary thyroid cancer, which required repeated thyroidectomy followed by radioiodine I131 ablation. The postoperative period was uneventful; the patient well tolerated suppressive levothyroxine therapy. Therefore, the presence of a toxic single nodular goiter does not exclude thyroid cancer, which defines the need to discuss the indications for FNAB of thyroid nodules in children.

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Expression of Caveolin-1 Is Associated With Thyroid Function in Patients With Human Papillary Thyroid Carcinoma

Dose-Response ◽

10.1177/1559325820919330 ◽

2020 ◽

Vol 18 (2) ◽

pp. 155932582091933

Author(s):

Jingyi Zhang ◽

Dongxia Yan ◽

Lianping He ◽

Qing Zhang ◽

Shuang Wen ◽

...

Keyword(s):

Thyroid Cancer ◽

Epithelial Cells ◽

Thyroid Nodule ◽

Papillary Thyroid Cancer ◽

Thyroid Function ◽

Follicular Adenoma ◽

Papillary Thyroid ◽

Follicular Thyroid Cancer ◽

Caveolin 1 ◽

Potential Biomarker

Objective: The aim of this study was to evaluate the levels of caveolin-1 in thyroid follicular epithelial cells of papillary thyroid cancer, follicular thyroid cancer, and nonmalignant thyroid nodule benign follicular adenoma, as well as to explore the relationship between the levels of caveolin-1 and thyroid function. Methods: Thirty cases of papillary thyroid cancer, 10 cases of follicular thyroid cancer, 32 cases of nonmalignant thyroid nodule benign follicular adenoma, and 30 controls were enrolled in this study. Caveolin-1 expression in tissue specimens obtained from these cases was evaluated by immunohistochemistry and Western blotting. Results: Caveolin-1 expression in thyroid epithelial cells of patients with papillary thyroid cancer, particularly female patients, was significantly higher than that in patients with follicular thyroid cancer and nonmalignant thyroid nodule benign follicular adenoma ( P < .005). Serum thyroid-stimulating hormone (TSH) levels in the caveolin-1-positive expression group were lower than that in the caveolin-1-negative expression group, and the lowest expression of caveolin-1 was detected in tissues of patients with Graves’ disease. The serum TSH level was associated with caveolin-1 expression in thyroid epithelial cells. Conclusion: Caveolin-1 may participate in regulating thyroid function and is a potential biomarker of follicular thyroid cancer.

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Autonomously functioning thyroid nodule treated with radioactive iodine and later diagnosed as papillary thyroid cancer

HORMONES ◽

10.1007/bf03401510 ◽

2008 ◽

Vol 7 (2) ◽

pp. 175-179 ◽

Cited By ~ 12

Author(s):

Mehmet Uludag ◽

Gurkan Yetkin ◽

Bulent Citgez ◽

Adnan Isgor ◽

Tulay Basak

Keyword(s):

Thyroid Cancer ◽

Thyroid Nodule ◽

Papillary Thyroid Cancer ◽

Radioactive Iodine ◽

Papillary Thyroid

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Serum Adiponectin and Progranulin Level in Patients with Benign Thyroid Nodule or Papillary Thyroid Cancer

Endocrinology and Metabolism ◽

10.3803/enm.2020.35.2.396 ◽

2020 ◽

Vol 35 (2) ◽

pp. 396-406

Author(s):

Hyemi Kwon ◽

Se Eun Park ◽

Ji-Sup Yun ◽

Cheol-Young Park

Keyword(s):

Thyroid Cancer ◽

Thyroid Nodule ◽

Papillary Thyroid Cancer ◽

Serum Adiponectin ◽

Papillary Thyroid ◽

Benign Thyroid Nodule ◽

Benign Thyroid

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B-RAF V600E mutational analysis of fine needle aspirates correlates with diagnosis of thyroid nodules

Otolaryngology ◽

10.1016/j.otohns.2009.01.007 ◽

2009 ◽

Vol 140 (5) ◽

pp. 709-714 ◽

Cited By ~ 13

Author(s):

Brandon G. Bentz ◽

Brian T. Miller ◽

Joseph A. Holden ◽

Leslie R. Rowe ◽

Joel S. Bentz

Keyword(s):

Thyroid Cancer ◽

Thyroid Nodule ◽

Treatment Planning ◽

Papillary Thyroid Cancer ◽

Thyroid Nodules ◽

Melting Curve Analysis ◽

Papillary Thyroid ◽

Follicular Variant ◽

Fine Needle ◽

Mutational Status

Objective: A mutation of B-type RAF kinase (B-RAF) represents the most common genetic alteration in papillary thyroid cancer (PTC), possibly signifying a more aggressive biology. Fine needle aspiration (FNA) represents the most useful initial diagnostic tool of thyroid nodules. Molecular analysis of the mutation status of B-RAF in thyroid nodule FNAs may provide guidance for treatment planning. Study Design: Cross-sectional study. Subjects and Methods: A retrospective chart review was undertaken for clinically relevant data of papillary thyroid cancer (PTC), follicular variant of PTC (FV-PTC), and nonmalignant goiters. After blinded pathologic review, histologic and cytologic samples were analyzed by LightCycler PCR (LCPCR) with allele-specific fluorescent probe melting curve analysis (FMCA) for the V600E mutation of B-RAF. Results: Of the 45 patient samples analyzed, B-RAF mutation was found to be significantly higher in papillary carcinomas when compared to follicular variant of papillary thyroid carcinomas (55.6% vs 14.3%, P = 0.05). Pathologic B-RAF mutational status significantly correlated with cytologic B-RAF mutational status ( P < 0.0001), cytologic interpretation ( P = 0.012), and histologic diagnosis ( P = 0.011). Conclusions: Determination of B-RAF V600E mutation of thyroid nodule FNAs by LCPCR may be a useful tool to guide treatment planning. These data support investigating the utility of this molecular marker in a prospective manner.

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