Expression of Caveolin-1 Is Associated With Thyroid Function in Patients With Human Papillary Thyroid Carcinoma

Objective: The aim of this study was to evaluate the levels of caveolin-1 in thyroid follicular epithelial cells of papillary thyroid cancer, follicular thyroid cancer, and nonmalignant thyroid nodule benign follicular adenoma, as well as to explore the relationship between the levels of caveolin-1 and thyroid function. Methods: Thirty cases of papillary thyroid cancer, 10 cases of follicular thyroid cancer, 32 cases of nonmalignant thyroid nodule benign follicular adenoma, and 30 controls were enrolled in this study. Caveolin-1 expression in tissue specimens obtained from these cases was evaluated by immunohistochemistry and Western blotting. Results: Caveolin-1 expression in thyroid epithelial cells of patients with papillary thyroid cancer, particularly female patients, was significantly higher than that in patients with follicular thyroid cancer and nonmalignant thyroid nodule benign follicular adenoma ( P < .005). Serum thyroid-stimulating hormone (TSH) levels in the caveolin-1-positive expression group were lower than that in the caveolin-1-negative expression group, and the lowest expression of caveolin-1 was detected in tissues of patients with Graves’ disease. The serum TSH level was associated with caveolin-1 expression in thyroid epithelial cells. Conclusion: Caveolin-1 may participate in regulating thyroid function and is a potential biomarker of follicular thyroid cancer.

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Strong association of high urinary iodine with thyroid nodule and papillary thyroid cancer

Tumor Biology ◽

10.1007/s13277-014-2397-8 ◽

2014 ◽

Vol 35 (11) ◽

pp. 11375-11379 ◽

Cited By ~ 19

Author(s):

Fang Wang ◽

Yangang Wang ◽

Luan Wang ◽

Xiuxiu Wang ◽

Chun Sun ◽

...

Keyword(s):

Thyroid Cancer ◽

Thyroid Nodule ◽

Papillary Thyroid Cancer ◽

Strong Association ◽

Urinary Iodine ◽

Papillary Thyroid

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LncRNA LINC00460 promotes the papillary thyroid cancer progression by regulating the LINC00460/miR-485-5p/Raf1 axis

Biological Research ◽

10.1186/s40659-019-0269-9 ◽

2019 ◽

Vol 52 (1) ◽

Cited By ~ 6

Author(s):

Guangjun Li ◽

Qingli Kong

Keyword(s):

Thyroid Cancer ◽

Papillary Thyroid Cancer ◽

Cancer Progression ◽

Binding Sites ◽

Luciferase Reporter ◽

Reporter Assay ◽

Papillary Thyroid ◽

Potential Biomarker ◽

Common Malignancy

Abstract Background Papillary thyroid cancer (PTC) is the most common malignancy of all thyroid cancers. LncRNA LINC00460 has been proved to play roles in the oncogenesis and progression of various tumors, including papillary thyroid cancer. However, the potential molecular mechanism of LINC00460 in PTC is poorly investigated. Results LINC00460 was upregulated in PTC tissues and cells. Raf1 was upregulated in PTC tissues, but miR-485-5p was down-regulated. High LINC00460 expression was associated with poor prognosis. LINC00460 knockdown suppressed proliferation, migration, invation and EMT of PTC cells. Bioinformatics prediction revealed that LINC00460 had binding sites with miR-485-5p, which was validated by luciferase reporter assay. In addition, miR-485-5p was confirmed to directly target Raf1 3′-UTR. Moreover, LINC00460 promoted PTC progression by sponging miR-485-5p to elevate the expression of Raf1. Knockdown of LINC00460 restrained tumor growth in vivo. Conclusion LINC00460 induced proliferation, migration, invation and EMT of PTC cells by regulating the LINC00460/miR-485-5p/Raf1 axis, which indicated that LINC00460 may be a potential biomarker and therapeutic target for PTC.

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Expression of intercellular adhesion molecule-1 (ICAM-1) on thyroid epithelial cells in Hashimoto's thyroiditis but not in Graves' disease or papillary thyroid cancer

Clinical & Experimental Immunology ◽

10.1111/j.1365-2249.1991.tb05633.x ◽

2008 ◽

Vol 83 (2) ◽

pp. 309-313 ◽

Cited By ~ 46

Author(s):

M. BAGNASCO ◽

A. CARETTO ◽

D. OLIVE ◽

B. PEDINI ◽

G. W. CANONICA ◽

...

Keyword(s):

Thyroid Cancer ◽

Epithelial Cells ◽

Papillary Thyroid Cancer ◽

Adhesion Molecule ◽

Intercellular Adhesion ◽

Intercellular Adhesion Molecule ◽

Hashimoto's Thyroiditis ◽

Graves Disease ◽

Papillary Thyroid ◽

Intercellular Adhesion Molecule 1

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Spectrum and Prevalence of Thyroid Diseases at a Tertiary Referral Hospital in Mogadishu, Somalia: A Retrospective Study of 976 Cases

International Journal of Endocrinology ◽

10.1155/2021/7154250 ◽

2021 ◽

Vol 2021 ◽

pp. 1-7

Author(s):

Mohamed A. Hassan-Kadle ◽

Abdulkamil Abdullahi Adani ◽

Hasan Huseyin Eker ◽

Esra Keles ◽

Marian Muse Osman ◽

...

Keyword(s):

Thyroid Cancer ◽

Thyroid Function ◽

Thyroid Function Tests ◽

Thyroid Disorder ◽

Papillary Thyroid ◽

Follicular Thyroid Cancer ◽

Tertiary Referral ◽

Tertiary Referral Hospital ◽

Euthyroid Sick Syndrome ◽

Thyroid Malignancies

Background. Thyroid disorder is one of the most common noncommunicable diseases worldwide and neglected public health issues in Somalia. The aim of the study thus was to investigate the thyroid disorders in patients attending to the largest tertiary referral hospital in Somalia. Methods. This retrospective study was conducted on patients admitted to the internal department of Somalia Mogadishu-Turkey Education and Research Hospital, Somali, between January 2017 and December 2019. Patients who were tested for thyroid function tests and had complete data were included. Patients with incomplete data and currently treated for any thyroid disorder were excluded from the study. Abstracted data including patients’ sociodemographic characteristics, thyroid function tests, and histopathological findings were retrieved from the hospital database system. Results. A total of 976 patients with thyroid disorders were enrolled, of whom 66.6% (n = 650) were female and 33.4% (n = 326) were male. The mean age of the patients was 47 ± 18.5 years. The majority of the patients were reported in the 31–50 (35.9%) age range. The most reported thyroid function disorders were 58.8% euthyroid sick syndrome followed by 15.4% hypothyroidism, 12.5% subclinical hypothyroidism, 7.6% hyperthyroidism, and 5.7% subclinical hyperthyroidism. The distribution of comorbidity indicated that 13.4% had diabetes mellitus, 10.4% had HIV, 4.9% had malaria, and 4.5% had HIV and malaria coinfection. Thyroid malignancies were detached in 22 (2.2%) patients including eleven papillary thyroid cancer, nine patients had follicular thyroid cancer, and two patients had differentiated thyroid cancer. Conclusions. Euthyroid sick syndrome was the most common type of thyroid disease in our setup. Hypothyroidism is the second most common, followed by subclinical hypothyroidism. Papillary thyroid cancer was the predominant histology among thyroid malignancies, followed by follicular thyroid cancer. This study revealed that thyroid diseases emerge as an important endocrine disorder encountered in Somali, necessitating a major public health response.

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Papillary thyroid cancer in an adolescent with a toxic single nodular goiter

Problems of Endocrinology ◽

10.14341/probl2017632114-116 ◽

2017 ◽

Vol 63 (2) ◽

pp. 114-116 ◽

Cited By ~ 1

Author(s):

Olga S. Rogova ◽

Goar F. Okminyan ◽

Lubov N. Samsonova ◽

Elena V. Kiseleva ◽

Oleg Yu. Latyshev ◽

...

Keyword(s):

Thyroid Cancer ◽

Thyroid Nodule ◽

Papillary Thyroid Cancer ◽

Thyroid Nodules ◽

Fine Needle Aspiration Biopsy ◽

Nodular Goiter ◽

Needle Aspiration ◽

Papillary Thyroid ◽

Risk Of Malignancy ◽

Functional Autonomy

The rate of nodular goiter in children ranges from 0.05 to 5.1%; in this case, the risk of thyroid cancer in childhood amounts to 3―70% of all cases of thyroid pathology. Therefore, the main issue is the differential diagnosis of a nosological variant of a thyroid nodule, which defines the optimal therapeutic tactics for a particular patient. The risk of malignancy is traditionally believed to be low in the case of decompensated functional autonomy of a thyroid nodule; therefore, the need for fine needle aspiration biopsy (FNAB) followed by cytomorphological analysis of the aspirate is avoided in most cases. The presented clinical case demonstrates papillary cancer in an adolescent with a toxic single nodular goiter. A thyroid ultrasound examination revealed a nodular lesion in the boy. An increase in the thyroid size and thyrotoxicosis manifestation occurred 3 years later. A cytomorphological study identified follicular neoplasia; scintigraphy revealed a hot nodule. Surgical treatment was planned. Antithyroid therapy was prescribed to prepare for surgery. After compensation of thyrotoxicosis, hemithyroidectomy was performed. A histological examination diagnosed papillary thyroid cancer, which required repeated thyroidectomy followed by radioiodine I131 ablation. The postoperative period was uneventful; the patient well tolerated suppressive levothyroxine therapy. Therefore, the presence of a toxic single nodular goiter does not exclude thyroid cancer, which defines the need to discuss the indications for FNAB of thyroid nodules in children.

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Down-regulation of DANCR acts as a potential biomarker for papillary thyroid cancer diagnosis

Bioscience Reports ◽

10.1042/bsr20181616 ◽

2019 ◽

Vol 39 (4) ◽

Cited By ~ 4

Author(s):

Ke Zhang ◽

Jing Lv ◽

Xiaowei Peng ◽

Jianqiu Liu ◽

Cuilin Li ◽

...

Keyword(s):

Thyroid Cancer ◽

Papillary Thyroid Cancer ◽

Expression Profiles ◽

Expression Level ◽

Papillary Thyroid ◽

Normal Tissues ◽

Cancer Breast ◽

Tumor Tissues ◽

Potential Biomarker ◽

Reverse Transcription Quantitative Pcr

AbstractLong non-coding RNAs (lncRNAs) have been reported to be dysregulated and play a crucial role in the progression of cancer. LncRNA DANCR has recently been revealed to be involved in tumorigenesis of numerous types of cancer, including osteosarcoma, gastric cancer, breast cancer, hepatocellular carcinoma, and colorectal cancer. However, the expression profiles and biological relevance of DANCR in papillary thyroid cancer (PTC) have not yet been reported. In the present study, the expression level of DANCR in PTC tissues and adjacent normal tissues was detected by reverse transcription-quantitative PCR in PTC patients, and then we analyzed the association with clinical pathological characteristics of patients and DANCR expressions. These results demonstrated that the expression of DANCR was notably decreased in tumor tissues in comparison with adjacent normal tissues (P<0.001). Furthermore, the present study found that DANCR expression level was correlated to T grade (P<0.01) and TNM stage (P=0.017). The present study demonstrated that DANCR was associated with PTC aggressive clinical features and may serve as a diagnostic biomarker for detecting PTC patients.

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