scholarly journals Endothelin-1 Is Not Predictive of Ventricular Ectopy or Ventricular Fibrillation during Acute Myocardial Ischemia

2008 ◽  
Vol 28 (11) ◽  
pp. 639-641 ◽  
Author(s):  
Atman P. Shah ◽  
James T. Niemann ◽  
Scott Youngquist ◽  
Gary Josephson ◽  
John P. Rosborough
Keyword(s):  
Ventricular Fibrillation ◽  
Myocardial Ischemia ◽  
Acute Myocardial Ischemia ◽  
Ventricular Ectopy ◽  
Endothelin 1

Vagal reflexes and survival during acute myocardial ischemia in conscious dogs with healed myocardial infarction

1991 ◽  
Vol 261 (1) ◽  
pp. H63-H69 ◽  
Author(s):  
G. M. De Ferrari ◽  
E. Vanoli ◽  
M. Stramba-Badiale ◽  
S. S. Hull ◽  
R. D. Foreman ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Heart Rate ◽  
Coronary Artery ◽  
Ventricular Fibrillation ◽  
Myocardial Ischemia ◽  
Coronary Artery Occlusion ◽  
Artery Occlusion ◽  
Acute Myocardial Ischemia ◽  
Acute Ischemia ◽  
Control Test

The role of vagal tone and reflexes in the genesis of life-threatening arrhythmias was investigated in a clinically relevant animal model for sudden cardiac death. Forty-five dogs with a healed anterior myocardial infarction in which transient myocardial ischemia during exercise did not induce malignant arrhythmias were utilized for the study. They underwent a further exercise and ischemia test in which atropine (75 micrograms/kg) was injected before coronary artery occlusion. Novel occurrence of ventricular arrhythmia, or worsening of the type of arrhythmia present in the control test, occurred in 23 of 45 dogs (51%) and ventricular fibrillation occurred in 11 of 45 (24%, P = 0.001). Analysis of heart rate response to acute ischemia in the control test indicates that these 11 animals had powerful vagal reflexes during coronary artery occlusion, compared with the 34 survivors (-32 +/- 35 vs. +2 +/- 27 beats/min, P = 0.003). This study indicates that approximately 75% of animals resistant to ventricular fibrillation are characterized by weak sympathetic reflexes in response to acute myocardial ischemia. In the remaining 25% powerful vagal reflexes counteract concomitant reflex sympathetic hyperactivity, decrease heart rate, and are essential for survival.

Critical Role of Dose in Protection by Propranolol Against Ventricular Fibrillation in a Pig Model of Acute Myocardial Ischemia

1989 ◽  
Vol 13 (2) ◽  
pp. 192-197 ◽  
Author(s):  
Cecilia A. Muller ◽  
Lionel H. Opie ◽  
Max Peisach ◽  
Carlos A. Pineda ◽  
Christian W. Hamm ◽  
...  
Keyword(s):  
Ventricular Fibrillation ◽  
Myocardial Ischemia ◽  
Critical Role ◽  
Acute Myocardial Ischemia ◽  
Pig Model
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