Association of CYP2D6 Single-Nucleotide Polymorphism with Response to Ophthalmic Timolol in Primary Open-Angle Glaucoma—A Pilot Study

2010 ◽  
Vol 26 (5) ◽  
pp. 497-501 ◽  
Author(s):  
Hongzhi Yuan ◽  
Minbin Yu ◽  
Yangfan Yang ◽  
Kaili Wu ◽  
Xianchai Lin ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphism ◽  
Pilot Study ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Open Angle ◽  
Nucleotide Polymorphism ◽  
Single Nucleotide

Myocilin mt.1 gene promoter single nucleotide polymorphism (-1000C>G) in Brazilian patients with primary open angle glaucoma

2010 ◽  
Vol 32 (1) ◽  
pp. 18-23 ◽  
Author(s):  
Niro Kasahara ◽  
Cristiano Caixeta-Umbelino ◽  
Maurício D. Paolera ◽  
Mylene N. Rocha ◽  
Flávio Richeti ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphism ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Gene Promoter ◽  
Open Angle ◽  
Nucleotide Polymorphism ◽  
Single Nucleotide

An update: mechanisms of microRNA in primary open-angle glaucoma

2020 ◽  
Author(s):  
Yuanping Wang ◽  
Lingzhi Niu ◽  
Jing Zhao ◽  
Mingxuan Wang ◽  
Ke Li ◽  
...  
Keyword(s):  
Intraocular Pressure ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Nucleotide Polymorphisms ◽  
Open Angle ◽  
Single Nucleotide ◽  
Optic Nerve Damage ◽  
The World ◽  
And Function ◽  
Main Factor

Abstract Glaucoma is a disease with characteristic optic neuropathy and loss of vision, leading to blindness, and primary open-angle glaucoma (POAG) is the most common glaucoma type throughout the world. Genetic susceptibility is the main factor in POAG, and most susceptibility genes cause changes in microRNA expression and function, thereby leading to POAG occurrence and development. Increasing evidence indicates that many microRNAs are involved in the regulation of intraocular pressure (IOP) and play an important role in the increase in IOP in POAG. Additionally, microRNA is closely related to optic nerve damage factors (mechanical stress, hypoxia and inflammation). This review discusses the effect of single-nucleotide polymorphisms in POAG-related genes on microRNA and the value of microRNA in the diagnosis and treatment of POAG.

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