Impact of Farnesol as a Modulator of Efflux Pumps in a Fluconazole-Resistant Strain of Candida albicans

2019 ◽  
Vol 25 (6) ◽  
pp. 805-812 ◽  
Author(s):  
Lucia Černáková ◽  
Stanislava Dižová ◽  
Dana Gášková ◽  
Iva Jančíková ◽  
Helena Bujdáková
Keyword(s):  
Candida Albicans ◽  
Resistant Strain ◽  
Efflux Pumps ◽  
Fluconazole Resistant

The Role of Curcumin in Inhibiting Growth of Oropharyngeal Isolates of Candida albicans Fluconazole-Resistant Strain from HIV Patients through Decreased Cdr1p Expression

2018 ◽  
Vol 10 (1) ◽  
pp. 29
Author(s):  
Novida Ariani ◽  
Mulyohadi Ali ◽  
Noorhamdani ◽  
Aulanni'am Aulanni'am ◽  
Budi Santoso ◽  
...  
Keyword(s):  
Candida Albicans ◽  
Resistant Strain ◽  
Hiv Patients ◽  
Fluconazole Resistant

Matrine reduces yeast-to-hypha transition and resistance of a fluconazole-resistant strain of Candida albicans

2014 ◽  
Vol 117 (3) ◽  
pp. 618-626 ◽  
Author(s):  
J. Shao ◽  
T. Wang ◽  
Y. Yan ◽  
G. Shi ◽  
H. Cheng ◽  
...  
Keyword(s):  
Candida Albicans ◽  
Resistant Strain ◽  
Fluconazole Resistant

scholarly journals Synthetic Organotellurium Compounds Sensitize Drug-Resistant Candida albicans Clinical Isolates to Fluconazole

2016 ◽  
Vol 61 (1) ◽  
Author(s):  
L. F. Reis de Sá ◽  
F. T. Toledo ◽  
A. C. Gonçalves ◽  
B. A. Sousa ◽  
A. A. dos Santos ◽  
...  
Keyword(s):  
Candida Albicans ◽  
Efflux Pumps ◽  
Major Facilitator Superfamily ◽  
Clinical Isolates ◽  
Multidrug Efflux ◽  
Fluconazole Resistance ◽  
Content Type ◽  
Multidrug Efflux Pumps ◽  
Fluconazole Resistant ◽  
Organotellurium Compounds

ABSTRACT Invasive Candida albicans infections are a serious health threat for immunocompromised individuals. Fluconazole is most commonly used to treat these infections, but resistance due to the overexpression of multidrug efflux pumps is of grave concern. This study evaluated the ability of five synthetic organotellurium compounds to reverse the fluconazole resistance of C. albicans clinical isolates. Compounds 1 to 4, at <10 μg/ml, ameliorated the fluconazole resistance of Saccharomyces cerevisiae strains overexpressing the major C. albicans multidrug efflux pumps Cdr1p and Mdr1p, whereas compound 5 only sensitized Mdr1p-overexpressing strains to fluconazole. Compounds 1 to 4 also inhibited efflux of the fluorescent substrate rhodamine 6G and the ATPase activity of Cdr1p, whereas all five of compounds 1 to 5 inhibited Nile red efflux by Mdr1p. Interestingly, all five compounds demonstrated synergy with fluconazole against efflux pump-overexpressing fluconazole-resistant C. albicans clinical isolates, isolate 95-142 overexpressing CDR1 and CDR2, isolate 96-25 overexpressing MDR1 and ERG11, and isolate 12-99 overexpressing CDR1, CDR2, MDR1, and ERG11. Overall, organotellurium compounds 1 and 2 were the most promising fluconazole chemosensitizers of fluconazole-resistant C. albicans isolates. Our data suggest that these novel organotellurium compounds inhibit pump efflux by two very important and distinct families of fungal multidrug efflux pumps: the ATP-binding cassette transporter Cdr1p and the major facilitator superfamily transporter Mdr1p.

scholarly journals Ibuprofen Potentiates theIn VivoAntifungal Activity of Fluconazole against Candida albicans Murine Infection

2015 ◽  
Vol 59 (7) ◽  
pp. 4289-4292 ◽  
Author(s):  
Sofia Costa-de-Oliveira ◽  
Isabel M. Miranda ◽  
Ana Silva-Dias ◽  
Ana P. Silva ◽  
Acácio G. Rodrigues ◽  
...  
Keyword(s):  
Candida Albicans ◽  
Antifungal Activity ◽  
Murine Model ◽  
Resistant Strain ◽  
Efflux Pump ◽  
Systemic Infection ◽  
New Approach ◽  
Content Type ◽  
Fungal Burden ◽  
Fluconazole Resistant

ABSTRACTCandida albicansis the most prevalent cause of fungemia worldwide. Its ability to develop resistance in patients receiving azole antifungal therapy is well documented. In a murine model of systemic infection, we show that ibuprofen potentiates fluconazole antifungal activity against a fluconazole-resistant strain, drastically reducing the fungal burden and morbidity. The therapeutic combination of fluconazole with ibuprofen may constitute a new approach for the management of antifungal therapeutics to reverse the resistance conferred by efflux pump overexpression.

Expression of Major Efflux Pumps in Fluconazole-Resistant Candida albicans

2017 ◽  
Vol 17 (3) ◽  
Author(s):  
Babak Pourakbari ◽  
Mostafa Teymuri ◽  
Shima Mahmoudi ◽  
Sepideh K. Valian ◽  
Zahra Movahedi ◽  
...  
Keyword(s):  
Candida Albicans ◽  
Efflux Pumps ◽  
Fluconazole Resistant

Investigation of the Expression Levels of Efflux Pumps in Fluconazole-Resistant Candida albicans Isolates

2014 ◽  
Vol 48 (2) ◽  
pp. 325-334 ◽  
Author(s):  
Sinem GÜLAT ◽  
Mine DOLUCA DERELİ
Keyword(s):  
Candida Albicans ◽  
Efflux Pumps ◽  
Expression Levels ◽  
Fluconazole Resistant

scholarly journals Suppression of Fluconazole Resistant Candida albicans Biofilm Formation and Filamentation by Methylindole Derivatives

2018 ◽  
Vol 9 ◽  
Author(s):  
Jin-Hyung Lee ◽  
Yong-Guy Kim ◽  
Vivek Kumar Gupta ◽  
Ranjith Kumar Manoharan ◽  
Jintae Lee
Keyword(s):  
Candida Albicans ◽  
Biofilm Formation ◽  
Fluconazole Resistant
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