Enhanced Bone Regeneration at a Segmental Bone Defect by Controlled Release of Bone Morphogenetic Protein-2 from a Biodegradable Hydrogel

2006 ◽  
Vol 0 (0) ◽  
pp. 060511071910001
Author(s):  
Masaya Yamamoto ◽  
Yoshitake Takahashi ◽  
Yasuhiko Tabata
Keyword(s):  
Controlled Release ◽  
Bone Regeneration ◽  
Bone Morphogenetic Protein ◽  
Bone Defect ◽  
Bone Morphogenetic Protein 2 ◽  
Segmental Bone Defect ◽  
Morphogenetic Protein ◽  
Biodegradable Hydrogel ◽  
Segmental Bone

Bone Induction by Controlled Release of BMP-2 from a Biodegradable Hydrogel in Various Animal Species - From Mouse to Non-Human Primate -

2005 ◽  
Vol 288-289 ◽  
pp. 253-256 ◽  
Author(s):  
Masaya Yamamoto ◽  
Yoshitake Takahashi ◽  
Yasuhiko Tabata
Keyword(s):  
Controlled Release ◽  
Bone Regeneration ◽  
Bone Morphogenetic Protein ◽  
Bone Defect ◽  
Animal Species ◽  
Bone Induction ◽  
Morphogenetic Protein ◽  
Biodegradable Hydrogel ◽  
Human Primate ◽  
Hydrogel System

The objective of this study is to examine feasibility of biodegradable gelatin hydrogels incorporating bone morphogenetic protein (BMP)-2 in inducing bone regeneration at a bone defect of non-human primates and rabbits considering their BMP-2 release profiles. As a result, controlled release by the hydrogel system enabled BMP-2 to induce successful bone regeneration in non-human primates even at the BMP-2 dose as low as that for rabbit case (0.034 mg of BMP-2/cm3 of hydrogel).

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