The Use of Endothelial Progenitor Cells for Prevascularized Bone Tissue Engineering

2009 ◽  
Vol 15 (8) ◽  
pp. 2015-2027 ◽  
Author(s):  
Jeroen Rouwkema ◽  
Peter E. Westerweel ◽  
Jan de Boer ◽  
Marianne C. Verhaar ◽  
Clemens A. van Blitterswijk
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Progenitor Cells ◽  
Bone Tissue ◽  
Endothelial Progenitor Cells ◽  
Endothelial Progenitor

miR-126 modulates angiogenic growth parameters of peripheral blood endothelial progenitor cells

2015 ◽  
Vol 396 (3) ◽  
pp. 245-252 ◽  
Author(s):  
Sebastian M. Goerke ◽  
Lena S. Kiefer ◽  
G. Björn Stark ◽  
Filip Simunovic ◽  
Günter Finkenzeller
Keyword(s):  
Tissue Engineering ◽  
Progenitor Cells ◽  
Endothelial Progenitor Cells ◽  
Peripheral Blood ◽  
Growth Parameters ◽  
Therapeutic Option ◽  
Tube Formation ◽  
Loss Of Function ◽  
Endothelial Progenitor

Abstract Vascularization plays an important role in tissue engineering applications. It is known that implantation of differentiated endothelial cells or endothelial progenitor cells (EPCs) from cord blood (cbEPCs) gives rise to the formation of a complex functional neovasculature, whereas EPCs isolated from peripheral blood (pbEPCs) have a limited capability to form blood vessels upon implantation. MicroRNA-126 (miR-126) has been shown to have pro-angiogenic effects in vivo. In this study, we investigated whether modulation of miR-126 expression in pbEPCs may alter their angiogenic properties. Gain of function and loss of function experiments revealed that miR-126 has anti-angiogenic effects in pbEPCs. Overexpression of miR-126 resulted in decreased proliferation, migration, invasion and tube formation, while inhibition of miR-126 induced the opposite effects. However, modulation of miR-126 expression did not influence apoptotic susceptibility of pbEPCs. This study provides evidence that inhibition of miR-126 improves angiogenesis-related growth parameters in pbEPCs and may represent a therapeutic option to ameliorate the angiogenic and vasculogenic properties of pbEPCs.

scholarly journals Relative contributions of adipose-resident CD146+ pericytes and CD34+ adventitial progenitor cells in bone tissue engineering

2019 ◽  
Vol 4 (1) ◽  
Author(s):  
Yiyun Wang ◽  
Jiajia Xu ◽  
Leslie Chang ◽  
Carolyn A. Meyers ◽  
Lei Zhang ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Progenitor Cells ◽  
Bone Tissue

Labeling and Qualification of Endothelial Progenitor Cells for Tracking in Tissue Engineering: An in Vitro Study

2015 ◽  
Vol 38 (4) ◽  
pp. 224-232 ◽  
Author(s):  
Noélie B. Thébaud ◽  
Audrey Aussel ◽  
Robin Siadous ◽  
Jérome Toutain ◽  
Reine Bareille ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Progenitor Cells ◽  
Endothelial Progenitor Cells ◽  
In Vitro Study ◽  
Vitro Study ◽  
Endothelial Progenitor
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