Role of Insulin and Serum on Thyrotropin Regulation of Thyroid Transcription Factor-1 and Pax-8 Genes Expression in FRTL-5 Thyroid Cells

Thyroid ◽  
2000 ◽  
Vol 10 (4) ◽  
pp. 295-303 ◽  
Author(s):  
Diego L. Medina ◽  
Koichi Suzuki ◽  
Michele Pietrarelli ◽  
Fumi Okajima ◽  
Leonard D. Kohn ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Thyroid Cells ◽  
Thyroid Transcription Factor 1 ◽  
Thyroid Transcription Factor ◽  
Genes Expression ◽  
Transcription Factor 1

Role of thyroid transcription factor-1 in the diagnosis of feline lung–digit syndrome

2016 ◽  
Vol 19 (4) ◽  
pp. 477-483 ◽  
Author(s):  
Riccardo Finotello ◽  
Carlo Masserdotti ◽  
Gianna Baroni ◽  
Lorenzo Ressel
Keyword(s):  
Transcription Factor ◽  
Control Group ◽  
Study Group ◽  
Ciliated Epithelium ◽  
Neoplastic Tissue ◽  
Thyroid Transcription Factor 1 ◽  
Thyroid Transcription Factor ◽  
Formalin Fixed Paraffin Embedded ◽  
Transcription Factor 1

Objectives The aim of this study was to investigate the role of thyroid transcription factor-1 (TTF-1) in the diagnosis of feline lung–digit syndrome (FLDS) and to investigate the associations between the morphological features of FLDS and TTF-1 expression. We also compared the reliability of TTF-1 and transmission electron microscopy (TEM) in establishing the diagnosis of FLDS. Methods Histology records of feline digit tumours were retrieved, including patients from 2008–2015. If formalin-fixed, paraffin-embedded tissues were available for review, patients were included in the study. As a control group we included 12 feline primary tumours of the digits. All the histological slides of the study group were blindly reviewed by the same veterinary pathologist. Representative sections of the lesions were selected for immunohistochemistry (IHC) analysis. To confirm the respiratory origin of the neoplastic tissue, TEM was used as a gold standard in all cases. Results Five cases of FLDS were included. TTF-1 was weakly to moderately positive in 60% of the cases, showing no correlation with the microscopic presence of ciliated epithelium. When IHC results were combined with the presence of cilia, 80% of the cases from the study group could be identified as FLDS. TEM confirmed the presence of ciliated epithelium in all five cases, confirming the respiratory origin of the neoplastic tissue and therefore the diagnosis of FLDS. Conclusions and relevance TTF-1 expression is maintained in FLDS. While the combination of TTF-1 and identification of cilia confirms FLDS, TEM should be considered in those cases where diagnosis is uncertain and FLDS is suspected.

Functional inactivation of thyroid transcription factor-1 in PCCl3 thyroid cells

2012 ◽  
Vol 358 (1) ◽  
pp. 36-45 ◽  
Author(s):  
Christiane Christophe-Hobertus ◽  
Anne Lefort ◽  
Frederick Libert ◽  
Daniel Christophe
Keyword(s):  
Transcription Factor ◽  
Thyroid Cells ◽  
Thyroid Transcription Factor 1 ◽  
Thyroid Transcription Factor ◽  
Functional Inactivation ◽  
Transcription Factor 1

scholarly journals The prognostic role of thyroid transcription factor-1 in lung adenocarcinoma

2020 ◽  
Vol 16 (4) ◽  
pp. 737 ◽  
Author(s):  
Esin Oktay ◽  
Utku Oflazoglu ◽  
Yelda Varol ◽  
Ozgur Tanriverdi ◽  
Necla Mermur ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Lung Adenocarcinoma ◽  
Prognostic Role ◽  
Thyroid Transcription Factor 1 ◽  
Thyroid Transcription Factor ◽  
Transcription Factor 1

scholarly journals The role of Thyroid Transcription Factor-1 and Tumor differentiation in Resected Lung Adenocarcinoma

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Tsai-Wang Huang ◽  
Ke- Feng Lin ◽  
Chien-Hsing Lee ◽  
Hung Chang ◽  
Shih-Chun Lee ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Lung Adenocarcinoma ◽  
Tumor Differentiation ◽  
Thyroid Transcription Factor 1 ◽  
Thyroid Transcription Factor ◽  
Transcription Factor 1
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