scholarly journals Overview and Management of Dermatologic Events Associated with Targeted Therapies for Medullary Thyroid Cancer

Thyroid ◽  
2014 ◽  
Vol 24 (9) ◽  
pp. 1329-1340 ◽  
Author(s):  
Mario E. Lacouture ◽  
Kathryn Ciccolini ◽  
Richard T. Kloos ◽  
Mark Agulnik
Keyword(s):  
Thyroid Cancer ◽  
Targeted Therapies ◽  
Medullary Thyroid Cancer ◽  
Medullary Thyroid

scholarly journals Efficacy and Tolerability of Pharmacotherapy Options for the Treatment of Medullary Thyroid Cancer

2012 ◽  
Vol 6 ◽  
pp. CMO.S8305 ◽  
Author(s):  
Hari A. Deshpande ◽  
Khushboo Sheth ◽  
Julie A. Sosa ◽  
Sanziana A. Roman
Keyword(s):  
Thyroid Cancer ◽  
Thyroid Carcinoma ◽  
Targeted Therapies ◽  
Medullary Thyroid Cancer ◽  
Advanced Disease ◽  
Efficacy And Safety ◽  
Conventional Chemotherapy ◽  
Medullary Thyroid ◽  
Novel Treatment ◽  
The Us

Metastatic and unresectable medullary thyroid carcinoma (MTC) is often difficult to treat as it is relatively unresponsive to radiation and conventional chemotherapy. This emphasizes the importance of the development of targeted therapies for advanced MTC. Vandetanib was approved by the US Food and Drug Administration for the treatment of symptomatic or progressive MTC in patients with advanced disease in April 2011. This therapy proved to be a breakthrough in the management of MTC. We review the efficacy and safety of this novel treatment and other treatments that are being evaluated in this disease.

Mouse models of medullary thyroid cancer and developing new targeted therapies

2016 ◽  
Vol 11 (10) ◽  
pp. 917-919 ◽  
Author(s):  
Rosa Maria Paragliola ◽  
Francesco Torino ◽  
Giampaolo Papi ◽  
Pietro Locantore ◽  
Alfredo Pontecorvi ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Mouse Models ◽  
Targeted Therapies ◽  
Medullary Thyroid Cancer ◽  
Medullary Thyroid

Medullary Thyroid Cancer

2018 ◽  
Author(s):  
Geeta Lal
Keyword(s):  
Thyroid Cancer ◽  
Targeted Therapies ◽  
Medullary Thyroid Cancer ◽  
Kinase Inhibitors ◽  
The United States ◽  
C Cells ◽  
Medullary Thyroid ◽  
Key Words Genetics ◽  
Thyroid C Cells ◽  
Men 2A

Medullary thyroid cancer (MTC) arises from the thyroid C-cells and accounts for 1 to 2% of thyroid cancers in the United States. Most tumors are sporadic but may occur as a part of the familial syndromes multiple endocrine neoplasia (MEN) 2A, MEN2B, and familial MTC. Surgery is the mainstay of treatment of these tumors, although recent advances in molecular genetics have enabled the development and use of targeted therapies such as tyrosine kinase inhibitors to treat patients with symptomatic metastatic disease.  This review contains 2 figures, 3 tables and 34 references Key Words: genetics, management, medullary thyroid cancer, MEN2A, MEN2B, targeted therapies

Medullary Thyroid Cancer

2018 ◽  
Author(s):  
Geeta Lal
Keyword(s):  
Thyroid Cancer ◽  
Targeted Therapies ◽  
Medullary Thyroid Cancer ◽  
Kinase Inhibitors ◽  
The United States ◽  
C Cells ◽  
Medullary Thyroid ◽  
Key Words Genetics ◽  
Thyroid C Cells ◽  
Men 2A

Medullary thyroid cancer (MTC) arises from the thyroid C-cells and accounts for 1 to 2% of thyroid cancers in the United States. Most tumors are sporadic but may occur as a part of the familial syndromes multiple endocrine neoplasia (MEN) 2A, MEN2B, and familial MTC. Surgery is the mainstay of treatment of these tumors, although recent advances in molecular genetics have enabled the development and use of targeted therapies such as tyrosine kinase inhibitors to treat patients with symptomatic metastatic disease.  This review contains 2 figures, 3 tables and 34 references Key Words: genetics, management, medullary thyroid cancer, MEN2A, MEN2B, targeted therapies

Abstract #1101 The Value of Calcitonin Calcium Stimulation Test Levels as Predictors of Medullary Thyroid Cancer.

2018 ◽  
Vol 24 ◽  
pp. 273-274
Author(s):  
Corin Badiu ◽  
Mara Baet ◽  
Ruxandra Dobrescu ◽  
Andra Caragheorgheopol ◽  
Corneci Cristina
Keyword(s):  
Thyroid Cancer ◽  
Medullary Thyroid Cancer ◽  
Stimulation Test ◽  
Medullary Thyroid ◽  
Calcium Stimulation

Intraoperative and postoperative care of unsuspected pheochromocytoma in medullary thyroid cancer

1994 ◽  
Vol 111 (5) ◽  
pp. 665-668
Author(s):  
S YEE ◽  
S STERN
Keyword(s):  
Thyroid Cancer ◽  
Postoperative Care ◽  
Medullary Thyroid Cancer ◽  
Medullary Thyroid

Immunoscintigraphy in Medullary Thyroid Cancer Using an 123I- or 111ln-Labelled Monoclonal Anti-CEA Antibody Fragment

1986 ◽  
Vol 25 (06) ◽  
pp. 227-231 ◽  
Author(s):  
Chr. Eilles ◽  
W. Spiegel ◽  
W. Becker ◽  
W. Börner ◽  
Chr. Reiners
Keyword(s):  
Bone Marrow ◽  
Thyroid Cancer ◽  
Potassium Iodide ◽  
Medullary Thyroid Cancer ◽  
Elevated Serum ◽  
Antibody Fragment ◽  
Special Importance ◽  
Medullary Thyroid ◽  
Medullary Cancer ◽  
Serum Cea

The monoclonal anti-CEA F(ab’)2 fragment MAb BW 431/31, labelled with 123I or111 In, was used for immunoscintigraphy (IS) in 9 patients with medullary cancer of the thyroid (CCC). The results of 11 studies lead to the following conclusions: 1) When using radioiodine as a label for MAb in IS, potassium iodide is absolutely necessary to block the thyroid which is of special importance in patients with thyroid cancer; 2) Preinjection of “cold” MAb reduces the relatively high unspecific uptake (especially in bone marrow) of MAb BW 431/31, which is of special importance for the antibody labelled with 111 In; 3) IS with MAb BW 413/31 in patients with CCC and elevated serum CEA is positive only in cases with large secondaries; and 4) In patients with CCC and several manifestations of secondaries, only a single (large) metastasis may be apparent.

NTRK3 receptor expression is strictly associated with medullary thyroid cancer RET mutation status

2014 ◽  
Author(s):  
Malgorzata Oczko-Wojciechowska ◽  
Michal Swierniak ◽  
Malgorzata Kowalska ◽  
Agnieszka Pawlaczek ◽  
Monika Kowal ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Medullary Thyroid Cancer ◽  
Receptor Expression ◽  
Mutation Status ◽  
Medullary Thyroid ◽  
Ret Mutation

Medullary thyroid cancer

2015 ◽  
Author(s):  
Thera P Links
Keyword(s):  
Thyroid Cancer ◽  
Medullary Thyroid Cancer ◽  
Medullary Thyroid
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