Lymphoproliferative and Serological Responses to Herpes Simplex Virus During Primary Infection, Recrudescence, and Re-Infection in a Murine Model

1989 ◽  
Vol 2 (2) ◽  
pp. 115-126 ◽  
Author(s):  
J.P. MAINGAY ◽  
S.E.M. HOWIE ◽  
M. NORVAL ◽  
A.M. MOODYCLIFFE ◽  
W.A. NEILL
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Murine Model ◽  
Primary Infection ◽  
Simplex Virus

Ultraviolet Light Induces Reactivation in a Murine Model of Cutaneous Herpes Simplex Virus-1 Infection¶

2001 ◽  
Vol 74 (1) ◽  
pp. 108 ◽  
Author(s):  
Diane E. Goade ◽  
Robert A. Nofchissey ◽  
Donna F. Kusewitt ◽  
Brian Hjelle ◽  
John Kreisel ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Ultraviolet Light ◽  
Murine Model ◽  
Herpes Simplex Virus 1 ◽  
Simplex Virus

scholarly journals CD11c Controls Herpes Simplex Virus 1 Responses To Limit Virus Replication during Primary Infection

2011 ◽  
Vol 85 (19) ◽  
pp. 9945-9955 ◽  
Author(s):  
S. J. Allen ◽  
K. R. Mott ◽  
A. A. Chentoufi ◽  
L. BenMohamed ◽  
S. L. Wechsler ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Virus Replication ◽  
Primary Infection ◽  
Herpes Simplex Virus 1 ◽  
Simplex Virus

Evaluation of a θ-Defensin in a Murine Model of Herpes Simplex Virus Type 1 Keratitis

2007 ◽  
Vol 48 (11) ◽  
pp. 5118 ◽  
Author(s):  
Curtis R. Brandt ◽  
Radeekorn Akkarawongsa ◽  
Sharon Altmann ◽  
Gilbert Jose ◽  
Aaron W. Kolb ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Virus Type ◽  
Murine Model ◽  
Herpes Simplex Virus Type ◽  
Simplex Virus

The role of the UL41 gene of herpes simplex virus type 1 in evasion of non-specific host defence mechanisms during primary infection

Microbiology ◽  
2000 ◽  
Vol 81 (7) ◽  
pp. 1763-1771 ◽  
Author(s):  
Tatsuo Suzutani ◽  
Masayoshi Nagamine ◽  
Taiichiro Shibaki ◽  
Masahiro Ogasawara ◽  
Itsuro Yoshida ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Virus Replication ◽  
Primary Infection ◽  
Interferon Α ◽  
Defence Mechanisms ◽  
Specific Host ◽  
Γ Ray ◽  
Simplex Virus

The UL41 gene product (vhs) of herpes simplex virus (HSV) is packaged in the virion, and mediates host protein synthesis shutoff at the early stage of the virus replication cycle. In order to clarify the role of vhs in virus replication and virulence, we isolated a completely UL41-deficient mutant (the VRΔ41 strain) and its revertant (the VRΔ41R strain). In the mouse encephalitis model, the replication of strain VRΔ41 was inhibited after 2 days post-infection, resulting in low virulence, by γ-ray-sensitive cells such as lymphocytes and/or neutrophils. The result suggested that some cytokines, produced in VRΔ41-inoculated brains, activate and induce the migration of γ-ray-sensitive cells to the infection site. Therefore, cytokines produced by HSV-1-infected human cells were screened, and potent inductions of interleukin (IL)-1β, IL-8 and macrophage inflammatory protein-1α by VRΔ41 infection were observed. Moreover, the VRΔ41 strain showed 20- and 5-fold higher sensitivity to interferon-α and -β compared to the wild-type strain, respectively. These results indicate that one important role of vhs in vivo is evasion from non-specific host defence mechanisms during primary infection through suppression of cytokine production in HSV-infected cells and reduction of the anti-HSV activity of interferon-α and -β.

Identification of women at unsuspected risk of primary infection with herpes simplex virus type 2 during pregnancy

1992 ◽  
Vol 39 (3) ◽  
pp. 248-248
Author(s):  
JA Kulhanjian ◽  
V Soroush ◽  
DS Au ◽  
RN Bronzan ◽  
LL Yasukawa ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Virus Type ◽  
Herpes Simplex Virus Type ◽  
Primary Infection ◽  
Simplex Virus

Latent herpes simplex virus in ganglia of mice after primary infection and reinoculation at a distant site

1978 ◽  
Vol 57 (2) ◽  
pp. 161-166 ◽  
Author(s):  
R. J. Klein ◽  
A. E. Friedman-Kien ◽  
Eileen Brady
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Primary Infection ◽  
Distant Site ◽  
Simplex Virus

scholarly journals Disseminated Herpes Simplex Virus Type 1 Primary Infection in a Healthy Individual

2009 ◽  
Vol 20 (4) ◽  
pp. 122-125 ◽  
Author(s):  
Guy Boivin ◽  
Brigitte Malette ◽  
Nathalie Goyette
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Primary Infection ◽  
Polymerase Chain Reaction Detection ◽  
Chain Reaction ◽  
Detection Techniques ◽  
Polymerase Chain ◽  
Simplex Virus ◽  
Hsv 1

BACKGROUND: Primary herpes simplex virus (HSV) infection usually involves one mucosal region.OBJECTIVE: To describe an unusual disseminated HSV-1 infection involving two mucosal sites in a healthy man.RESULTS: Primary HSV infection involved oral and genital mucosa and was associated with viremia, hepatitis and rash. Phylogenetic analysis of genital and oral viruses revealed that the patient was infected by a single HSV-1 strain.CONCLUSION: Use of polymerase chain reaction detection techniques for HSV may identify viremic patients in the absence of obvious immunosuppression.

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