Evaluation of a θ-Defensin in a Murine Model of Herpes Simplex Virus Type 1 Keratitis

2007 ◽  
Vol 48 (11) ◽  
pp. 5118 ◽  
Author(s):  
Curtis R. Brandt ◽  
Radeekorn Akkarawongsa ◽  
Sharon Altmann ◽  
Gilbert Jose ◽  
Aaron W. Kolb ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Virus Type ◽  
Murine Model ◽  
Herpes Simplex Virus Type ◽  
Simplex Virus

scholarly journals Efficacies of Topical Formulations of Foscarnet and Acyclovir and of 5-Percent Acyclovir Ointment (Zovirax) in a Murine Model of Cutaneous Herpes Simplex Virus Type 1 Infection

2000 ◽  
Vol 44 (1) ◽  
pp. 30-38 ◽  
Author(s):  
Jocelyne Piret ◽  
André Désormeaux ◽  
Pierrette Gourde ◽  
Julianna Juhász ◽  
Michel G. Bergeron
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Virus Type ◽  
Murine Model ◽  
Herpes Simplex Virus Type ◽  
Antiviral Effect ◽  
Single Application ◽  
Simplex Virus ◽  
Skin Samples

ABSTRACT The topical efficacies of foscarnet and acyclovir incorporated into a polyoxypropylene-polyoxyethylene polymer were evaluated and compared to that of 5% acyclovir ointment (Zovirax) by use of a murine model of cutaneous herpes simplex virus type 1 infection. All three treatments given three times daily for 4 days and initiated 24 h after infection prevented the development of the zosteriform rash in mice. The acyclovir formulation and the acyclovir ointment reduced the virus titers below detectable levels in skin samples from the majority of mice, whereas the foscarnet formulation has less of an antiviral effect. Reducing the number of treatments to a single application given 24 h postinfection resulted in a significantly higher efficacy of the formulation of acyclovir than of the acyclovir ointment. Acyclovir incorporated within the polymer was also significantly more effective than the acyclovir ointment when treatment was initiated on day 5 postinfection. The higher efficacy of the acyclovir formulation than of the acyclovir ointment is attributed to the semiviscous character of the polymer, which allows better penetration of the drug into the skin.

A Murine Model of Herpes Simplex Virus Type 1 of the Nervous System

1984 ◽  
Vol 436 (1 Multiple Scle) ◽  
pp. 504-505
Author(s):  
LORNE F. KASTRUKOFF ◽  
ALLEN S. LAU ◽  
DONALD W. PATY
Keyword(s):  
Nervous System ◽  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Virus Type ◽  
Murine Model ◽  
Herpes Simplex Virus Type ◽  
Simplex Virus

PS3-46 Differential inflammatory response to herpes simplex virus type 1 variants in a murine model

Cytokine ◽  
2010 ◽  
Vol 52 (1-2) ◽  
pp. 91
Author(s):  
M.C. Artuso ◽  
C. Mateu ◽  
S. Gazzaniga ◽  
C.A. Pujol ◽  
R. Wainstok ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Inflammatory Response ◽  
Virus Type ◽  
Murine Model ◽  
Herpes Simplex Virus Type ◽  
Simplex Virus

Role of herpes simplex virus type 1 (HSV-1) in the pathogenesis of peptic ulcer disease

2001 ◽  
Vol 120 (5) ◽  
pp. A136-A137
Author(s):  
K TSAMAKIDES ◽  
E PANOTOPOULOU ◽  
D DIMITROULOPOULOS ◽  
M CHRISTOPOULO ◽  
D XINOPOULOS ◽  
...  
Keyword(s):  
Peptic Ulcer ◽  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Peptic Ulcer Disease ◽  
Virus Type ◽  
Herpes Simplex Virus Type ◽  
Ulcer Disease ◽  
Simplex Virus
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