scholarly journals Control of radii of convergence and extension of subanalytic functions

2003 ◽  
Vol 132 (4) ◽  
pp. 997-1003 ◽  
Author(s):  
Edward Bierstone
Keyword(s):  
Subanalytic Functions ◽  
Convergence And Extension

scholarly journals Setdb2 controls convergence and extension movements during zebrafish gastrulation by transcriptional regulation of dvr1

2014 ◽  
Vol 392 (2) ◽  
pp. 233-244 ◽  
Author(s):  
Ting-Ting Du ◽  
Peng-Fei Xu ◽  
Zhi-Wei Dong ◽  
Hong-Bo Fan ◽  
Yi Jin ◽  
...  
Keyword(s):  
Transcriptional Regulation ◽  
Convergence And Extension

scholarly journals Unipolar distributions of junctional Myosin II identify cell stripe boundaries that drive cell intercalation throughout Drosophila axis extension

eLife ◽  
2016 ◽  
Vol 5 ◽  
Author(s):  
Robert J Tetley ◽  
Guy B Blanchard ◽  
Alexander G Fletcher ◽  
Richard J Adams ◽  
Bénédicte Sanson
Keyword(s):  
Myosin Ii ◽  
Interaction Model ◽  
Cell Interaction ◽  
Cell Number ◽  
Cell Polarization ◽  
Convergence And Extension ◽  
Pair Rule Gene ◽  
Cell Intercalation ◽  
Pair Rule ◽  
Cell Cell

Convergence and extension movements elongate tissues during development. Drosophila germ-band extension (GBE) is one example, which requires active cell rearrangements driven by Myosin II planar polarisation. Here, we develop novel computational methods to analyse the spatiotemporal dynamics of Myosin II during GBE, at the scale of the tissue. We show that initial Myosin II bipolar cell polarization gives way to unipolar enrichment at parasegmental boundaries and two further boundaries within each parasegment, concomitant with a doubling of cell number as the tissue elongates. These boundaries are the primary sites of cell intercalation, behaving as mechanical barriers and providing a mechanism for how cells remain ordered during GBE. Enrichment at parasegment boundaries during GBE is independent of Wingless signaling, suggesting pair-rule gene control. Our results are consistent with recent work showing that a combinatorial code of Toll-like receptors downstream of pair-rule genes contributes to Myosin II polarization via local cell-cell interactions. We propose an updated cell-cell interaction model for Myosin II polarization that we tested in a vertex-based simulation.

scholarly journals Pnas4is a novel regulator for convergence and extension during vertebrate gastrulation

FEBS Letters ◽  
2008 ◽  
Vol 582 (15) ◽  
pp. 2325-2332 ◽  
Author(s):  
Shaohua Yao ◽  
Lifang Xie ◽  
Meilin Qian ◽  
Hanshuo Yang ◽  
Lang Zhou ◽  
...  
Keyword(s):  
Convergence And Extension

Subanalytic Functions

1994 ◽  
Vol 344 (2) ◽  
pp. 583 ◽  
Author(s):  
Adam Parusinski
Keyword(s):  
Subanalytic Functions

scholarly journals Wnt/PCP signaling controls intracellular position of MTOCs during gastrulation convergence and extension movements

Development ◽  
2011 ◽  
Vol 138 (3) ◽  
pp. 543-552 ◽  
Author(s):  
D. S. Sepich ◽  
M. Usmani ◽  
S. Pawlicki ◽  
L. Solnica-Krezel
Keyword(s):  
Convergence And Extension ◽  
Pcp Signaling

Planar induction of convergence and extension of the neural plate by the organizer of Xenopus

1992 ◽  
Vol 193 (3) ◽  
pp. 218-234 ◽  
Author(s):  
Ray Keller ◽  
John Shih ◽  
Amy K. Sater ◽  
Cecelia Moreno
Keyword(s):  
Neural Plate ◽  
Convergence And Extension

scholarly journals Pitx2c orchestrates embryonic axis extension via mesendodermal cell migration

eLife ◽  
2018 ◽  
Vol 7 ◽  
Author(s):  
Michelle M Collins ◽  
Hans-Martin Maischein ◽  
Pascale Dufourcq ◽  
Marine Charpentier ◽  
Patrick Blader ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Cell Shape ◽  
Early Embryogenesis ◽  
Cell Behavior ◽  
Convergence And Extension ◽  
Transcriptional Changes ◽  
Axis Extension ◽  
Late Stages ◽  
Migration Network ◽  
Pitx2 Expression

Pitx2c, a homeodomain transcription factor, is classically known for its left-right patterning role. However, an early wave of pitx2 expression occurs at the onset of gastrulation in several species, indicating a possible earlier role that remains relatively unexplored. Here we show that in zebrafish, maternal-zygotic (MZ) pitx2c mutants exhibit a shortened body axis indicative of convergence and extension (CE) defects. Live imaging reveals that MZpitx2c mutants display less persistent mesendodermal migration during late stages of gastrulation. Transplant data indicate that Pitx2c functions cell non-autonomously to regulate this cell behavior by modulating cell shape and protrusive activity. Using transcriptomic analyses and candidate gene approaches, we identify transcriptional changes in components of the chemokine-ECM-integrin dependent mesendodermal migration network. Together, our results define pathways downstream of Pitx2c that are required during early embryogenesis and reveal novel functions for Pitx2c as a regulator of morphogenesis.

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