scholarly journals The critical set of the reduced norm, as an algebraic set

1975 ◽  
Vol 48 (2) ◽  
pp. 307-307
Author(s):  
Don Goelman
1994 ◽  
Vol 1 (3) ◽  
pp. 277-286
Author(s):  
G. Khimshiashvili

Abstract It is shown that the cardinality of a finite semi-algebraic subset over a real closed field can be computed in terms of signatures of effectively constructed quadratic forms.


Author(s):  
Matteo Tacchi ◽  
Tillmann Weisser ◽  
Jean Bernard Lasserre ◽  
Didier Henrion

Metabolites ◽  
2020 ◽  
Vol 10 (9) ◽  
pp. 346
Author(s):  
Adrian Benito ◽  
Nabil Hajji ◽  
Kevin O’Neill ◽  
Hector C. Keun ◽  
Nelofer Syed

Metabolic regulation of immune cells has arisen as a critical set of processes required for appropriate response to immunological signals. While our knowledge in this area has rapidly expanded in leukocytes, much less is known about the metabolic regulation of brain-resident microglia. In particular, the role of alternative nutrients to glucose remains poorly understood. Here, we use stable-isotope (13C) tracing strategies and metabolomics to characterize the oxidative metabolism of β-hydroxybutyrate (BHB) in human (HMC3) and murine (BV2) microglia cells and the interplay with glucose in resting and LPS-activated BV2 cells. We found that BHB is imported and oxidised in the TCA cycle in both cell lines with a subsequent increase in the cytosolic NADH:NAD+ ratio. In BV2 cells, stimulation with LPS upregulated the glycolytic flux, increased the cytosolic NADH:NAD+ ratio and promoted the accumulation of the glycolytic intermediate dihydroxyacetone phosphate (DHAP). The addition of BHB enhanced LPS-induced accumulation of DHAP and promoted glucose-derived lactate export. BHB also synergistically increased LPS-induced accumulation of succinate and other key immunometabolites, such as α-ketoglutarate and fumarate generated by the TCA cycle. Finally, BHB upregulated the expression of a key pro-inflammatory (M1 polarisation) marker gene, NOS2, in BV2 cells activated with LPS. In conclusion, we identify BHB as a potentially immunomodulatory metabolic substrate for microglia that promotes metabolic reprogramming during pro-inflammatory response.


2011 ◽  
Vol 215 (8) ◽  
pp. 1844-1851 ◽  
Author(s):  
Daniel J. Bates ◽  
Chris Peterson ◽  
Andrew J. Sommese ◽  
Charles W. Wampler

2009 ◽  
Vol 52 (2) ◽  
pp. 224-236
Author(s):  
Riccardo Ghiloni

AbstractLetRbe a real closed field, letX⊂Rnbe an irreducible real algebraic set and letZbe an algebraic subset ofXof codimension ≥ 2. Dubois and Efroymson proved the existence of an irreducible algebraic subset ofXof codimension 1 containingZ. We improve this dimension theorem as follows. Indicate by μ the minimum integer such that the ideal of polynomials inR[x1, … ,xn] vanishing onZcan be generated by polynomials of degree ≤ μ. We prove the following two results: (1) There exists a polynomialP∈R[x1, … ,xn] of degree≤ μ+1 such thatX∩P–1(0) is an irreducible algebraic subset ofXof codimension 1 containingZ. (2) LetFbe a polynomial inR[x1, … ,xn] of degreedvanishing onZ. Suppose there exists a nonsingular pointxofXsuch thatF(x) = 0 and the differential atxof the restriction ofFtoXis nonzero. Then there exists a polynomialG∈R[x1, … ,xn] of degree ≤ max﹛d, μ + 1﹜ such that, for eacht∈ (–1, 1) \ ﹛0﹜, the set ﹛x∈X|F(x) +tG(x) = 0﹜ is an irreducible algebraic subset ofXof codimension 1 containingZ. Result (1) and a slightly different version of result (2) are valid over any algebraically closed field also.


Author(s):  
Jean-Michel Bismut

This chapter studies the displacement function dᵧ on X that is associated with a semisimple element γ‎ ∈ G. If φ‎″, t ∈ R denotes the geodesic flow on the total space X of the tangent bundle of X, the critical set X(γ‎) ⊂ X of dᵧ can be easily related to the fixed point set Fᵧ ⊂ X of the symplectic transformation γ‎⁻¹φ‎₁ of X. The chapter studies the nondegeneracy of γ‎⁻¹φ‎₁ − 1 along Fᵧ. More fundamentally, this chapter gives important quantitative estimates on how much φ‎ ½ differs from φ‎ ˗½γ‎ away from Fᵧ. These quantitative estimates are based on Toponogov's theorem.


1992 ◽  
Vol 44 (6) ◽  
pp. 1262-1271 ◽  
Author(s):  
Murray Marshall

AbstractThe results obtained extend Madden’s result for Dedekind domains to more general types of 1-dimensional Noetherian rings. In particular, these results apply to piecewise polynomial functions t:C → R where R is a real closed field and C ⊆ Rn is a closed 1-dimensional semi-algebraic set, and also to the associated “relative” case where t, C are defined over some subfield K ⊆ R.


1999 ◽  
Vol 42 (4) ◽  
pp. 499-506 ◽  
Author(s):  
Alexandru Zaharia

AbstractA line singularity is a function germ with a smooth 1-dimensional critical set . An isolated line singularity is defined by the condition that for every x ≠ 0, the germ of f at (x, 0) is equivalent to . Simple isolated line singularities were classified by Dirk Siersma and are analogous of the famous A − D − E singularities. We give two new characterizations of simple isolated line singularities.


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