Depressed plasma Vitamin A and retinol-binding protein in cystic fibrosis correlations with zinc deficiency

1981 ◽  
Vol 34 (7) ◽  
pp. 1439-1440 ◽  
Author(s):  
J Navarro ◽  
N Desquilbet
Keyword(s):  
Cystic Fibrosis ◽  
Vitamin A ◽  
Zinc Deficiency ◽  
Binding Protein ◽  
Retinol Binding Protein ◽  
Plasma Vitamin

Plasma vitamin A and retinol-binding protein in premature and term neonates

1981 ◽  
Vol 99 (2) ◽  
pp. 302-305 ◽  
Author(s):  
Jayant P. Shenai ◽  
Frank Chytil ◽  
Asha Jhaveri ◽  
Mildred T. Stahlman
Keyword(s):  
Vitamin A ◽  
Binding Protein ◽  
Retinol Binding Protein ◽  
Plasma Vitamin ◽  
Term Neonates

Plasma vitamin a (Retinol) and retinol-binding protein in newborns and their mothers

1994 ◽  
Vol 14 (9) ◽  
pp. 1297-1303 ◽  
Author(s):  
Tapan K. Basu ◽  
Eleanor E. Wein ◽  
Kamalesh C. Gangopadhyay ◽  
Thomas M.S. Wolever ◽  
John C. Godel
Keyword(s):  
Vitamin A ◽  
Binding Protein ◽  
Retinol Binding Protein ◽  
Plasma Vitamin

scholarly journals Studies on Two Physiological Forms of the Human Retinol-binding Protein Differing in Vitamin A and Arginine Content

1971 ◽  
Vol 246 (21) ◽  
pp. 6638-6646
Author(s):  
Lars Rask ◽  
Anders Vahlquist ◽  
Per A. Peterson
Keyword(s):  
Vitamin A ◽  
Binding Protein ◽  
Retinol Binding Protein

scholarly journals CFTR Modulator Therapy with Lumacaftor/Ivacaftor Alters Plasma Concentrations of Lipid-Soluble Vitamins A and E in Patients with Cystic Fibrosis

Antioxidants ◽  
2021 ◽  
Vol 10 (3) ◽  
pp. 483
Author(s):  
Olaf Sommerburg ◽  
Susanne Hämmerling ◽  
S. Philipp Schneider ◽  
Jürgen Okun ◽  
Claus-Dieter Langhans ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Vitamin E ◽  
Vitamin A ◽  
Clinical Chemistry ◽  
Pancreatic Insufficiency ◽  
Plasma Concentrations ◽  
Plasma Vitamin ◽  
Hypervitaminosis A ◽  
Cholesterol Ratio ◽  
Fat Soluble Vitamins

Rationale: Cystic fibrosis (CF), caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, leads to impaired pancreatic function and therefore reduced intestinal absorption of lipids and fat-soluble vitamins especially in patients with CF developing pancreatic insufficiency (PI). Previous studies showed that CFTR modulator therapy with lumacaftor-ivacaftor (LUM/IVA) in Phe508del-homozygous patients with CF results in improvement of pulmonary disease and thriving. However, the effects of LUM/IVA on plasma concentration of the lipid soluble vitamins A and E remain unknown. Objectives: To investigate the course of plasma vitamin A and E in patients with CF under LUM/IVA therapy. Methods: Data from annual follow-up examinations of patients with CF were obtained to assess clinical outcomes including pulmonary function status, body mass index (BMI), and clinical chemistry as well as fat-soluble vitamins in Phe508del-homozygous CF patients before initiation and during LUM/IVA therapy. Results: Patients with CF receiving LUM/IVA improved substantially, including improvement in pulmonary inflammation, associated with a decrease in blood immunoglobulin G (IgG) from 9.4 to 8.2 g/L after two years (p < 0.001). During the same time, plasma vitamin A increased significantly from 1.2 to 1.6 µmol/L (p < 0.05), however, levels above the upper limit of normal were not detected in any of the patients. In contrast, plasma vitamin E as vitamin E/cholesterol ratio decreased moderately over the same time from 6.2 to 5.5 µmol/L (p < 0.01). Conclusions: CFTR modulator therapy with LUM/IVA alters concentrations of vitamins A and vitamin E in plasma. The increase of vitamin A must be monitored critically to avoid hypervitaminosis A in patients with CF.

scholarly journals The Effects of Chylomicron Vitamin A on the Metabolism of Retinol-binding Protein in the Rat

1973 ◽  
Vol 248 (5) ◽  
pp. 1544-1549 ◽  
Author(s):  
John Edgar Smith ◽  
Yasutoshi Muto ◽  
Peter O. Milch ◽  
DeWitt S. Goodman
Keyword(s):  
Vitamin A ◽  
Binding Protein ◽  
Retinol Binding Protein

scholarly journals Depressed plasma retinol-binding protein (RBP) in cystic fibrosis (CF)

1971 ◽  
Vol 5 (8) ◽  
pp. 390-390
Author(s):  
Frank Rees Smith ◽  
Barbara A Underwood ◽  
Carolyn R Denning ◽  
Dewitt S Goodman
Keyword(s):  
Cystic Fibrosis ◽  
Binding Protein ◽  
Retinol Binding Protein ◽  
Plasma Retinol
Sign in / Sign up

Export Citation Format

Share Document