scholarly journals Refinement of the modified-relative-dose-response test as a method for assessing vitamin A status in a field setting: experience with Indonesian children

1996 ◽  
Vol 64 (6) ◽  
pp. 966-971 ◽  
Author(s):  
S A Tanumihardjo ◽  
J C Cheng ◽  
D Permaesih ◽  
Muherdiyantiningsih ◽  
E Rustan ◽  
...  
Keyword(s):  
Vitamin A ◽  
Dose Response ◽  
Response Test ◽  
Vitamin A Status ◽  
Field Setting ◽  
Modified Relative Dose Response

scholarly journals Vitamin A intake and infection are associated with plasma retinol among pre-school children in rural Zambia

2012 ◽  
Vol 15 (9) ◽  
pp. 1688-1696 ◽  
Author(s):  
Christine Hotz ◽  
Justin Chileshe ◽  
Ward Siamusantu ◽  
Uma Palaniappan ◽  
Emmanuel Kafwembe
Keyword(s):  
Vitamin A ◽  
Dose Response ◽  
Acute Phase Proteins ◽  
Vitamin A Deficiency ◽  
Dietary Vitamin ◽  
Response Test ◽  
Post Harvest ◽  
Vitamin A Status ◽  
Plasma Retinol ◽  
Modified Relative Dose Response

AbstractObjectiveTo determine the prevalence of vitamin A deficiency, infection and adequacy of vitamin A intakes among Zambian children, and the contribution of dietary vitamin A and infection to vitamin A status.DesignA cross-sectional survey of vitamin A intakes by the 24 h recall method, vitamin A status by plasma retinol and the modified relative dose-response test, and infection by acute-phase proteins.SettingRural communities in Central and Eastern Provinces of Zambia.SubjectsChildren 2–5 years of age.ResultsThe prevalence of vitamin A deficiency was 56 % by plasma retinol, 48 % with infection-adjusted plasma retinol and 22 % by the modified relative dose-response test. The majority of children (61 %) had a current infection. Vitamin A intakes were relatively high (331 to 585 μg retinol activity equivalents/d in the harvest/early post-harvest and late post-harvest seasons, respectively) and the prevalence of inadequate intakes was <1 % when compared with the Estimated Average Requirement (210 and 275 μg retinol activity equivalents/d for children aged 1–3 and 4–8 years, respectively). Elevated α-1-acid glycoprotein was negatively associated with plasma retinol (P< 0·0 0 1) and vitamin A intake was positively associated with plasma retinol (P< 0·05), but only when estimated assuming a 26:1 retinol equivalence for provitamin A from green and yellow vegetables.ConclusionsInfection and vitamin A intakes were significant determinants of plasma retinol. We cannot conclude which indicator more accurately represents the true vitamin A status of the population. Reasons for the persistent high prevalence of vitamin A deficiency in the presence of adequate vitamin A intakes are unclear, but the high rates of infection may play a role.

Vitamin A status in preschool-age Indonesian children as assessed by the modified relative-dose-response assay

1990 ◽  
Vol 52 (6) ◽  
pp. 1068-1072 ◽  
Author(s):  
S A Tanumihardjo ◽  
Muhilal ◽  
Y Yuniar ◽  
D Permaesih ◽  
Z Sulaiman ◽  
...  
Keyword(s):  
Vitamin A ◽  
Dose Response ◽  
Preschool Age ◽  
Vitamin A Status ◽  
Modified Relative Dose Response

Studies on the application of the relative-dose-response test for assessing vitamin A status in older adults

1992 ◽  
Vol 56 (3) ◽  
pp. 543-547 ◽  
Author(s):  
J Bulux ◽  
E Carranza ◽  
C Castañeda ◽  
N W Solomons ◽  
L J Sokoll ◽  
...  
Keyword(s):  
Older Adults ◽  
Vitamin A ◽  
Dose Response ◽  
Response Test ◽  
Vitamin A Status
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