scholarly journals The Influence of Screening for Precancerous Lesions on Family-Based Genetic Association Tests: An Example of Colorectal Polyps and Cancer

2015 ◽  
Vol 182 (8) ◽  
pp. 714-722 ◽  
Author(s):  
Stephanie L. Schmit ◽  
Jane C. Figueiredo ◽  
Victoria K. Cortessis ◽  
Duncan C. Thomas
Keyword(s):  
Genetic Association ◽  
Precancerous Lesions ◽  
Colorectal Polyps ◽  
Association Tests ◽  
Genetic Association Tests ◽  
Family Based

Family-Based Genetic Association Tests

2011 ◽  
Vol 2011 (2) ◽  
pp. pdb.top96-pdb.top96 ◽  
Author(s):  
E. R. Martin ◽  
E. Rampersaud
Keyword(s):  
Genetic Association ◽  
Association Tests ◽  
Genetic Association Tests ◽  
Family Based

scholarly journals Genetic association tests: a method for the joint analysis of family and case-control data

2009 ◽  
Vol 4 (1) ◽  
pp. 2 ◽  
Author(s):  
Courtney Gray-McGuire ◽  
Murielle Bochud ◽  
Robert Goodloe ◽  
Robert C Elston
Keyword(s):  
Genetic Association ◽  
Case Control ◽  
Joint Analysis ◽  
Control Data ◽  
Association Tests ◽  
Genetic Association Tests

scholarly journals Correcting Systematic Inflation in Genetic Association Tests That Consider Interaction Effects

2014 ◽  
Vol 71 (12) ◽  
pp. 1392 ◽  
Author(s):  
Lynn M. Almli ◽  
Richard Duncan ◽  
Hao Feng ◽  
Debashis Ghosh ◽  
Elisabeth B. Binder ◽  
...  
Keyword(s):  
Genetic Association ◽  
Interaction Effects ◽  
Association Tests ◽  
Genetic Association Tests

scholarly journals Improving the power of genetic association tests with imperfect phenotype derived from electronic medical records

2014 ◽  
Vol 133 (11) ◽  
pp. 1369-1382 ◽  
Author(s):  
Jennifer A. Sinnott ◽  
Wei Dai ◽  
Katherine P. Liao ◽  
Stanley Y. Shaw ◽  
Ashwin N. Ananthakrishnan ◽  
...  
Keyword(s):  
Genetic Association ◽  
Electronic Medical Records ◽  
Medical Records ◽  
Association Tests ◽  
Genetic Association Tests

scholarly journals Statistical challenges in genetic association analyses: Populationbased versus family-based studies

2019 ◽  
Vol 79 (01S) ◽  
Author(s):  
Saurabh Ghosh ◽  
Tanushree Haldar
Keyword(s):  
Genetic Association ◽  
Complex Traits ◽  
Disease Status ◽  
Population Based ◽  
Association Tests ◽  
Association Analyses ◽  
Advantages And Disadvantages ◽  
Tests Of Association ◽  
Family Based ◽  
Study Designs

Genetic association tests provide clues on chromosomal locations of putative genes underlying complex traits, both qualitative (such as disease status) and quantitative (such as measurable precursors of clinical outcomes). One can adopt either a population-based or a family-based study design to generate genotype and phenotype data necessary to carry out the tests of association. In this article, we provide an overview of the two contrasting study designs, the statistical issues pertaining to each of these study designs as well as their relative advantages and disadvantages. We also outline the current statistical challenges in interpreting association findings in the presence of population stratification and in carrying out appropriate comparisons of the powers of the association tests based on the two study designs.

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