Phenotypic Screening for Kinase Targets Using Small Molecule Inhibitors with Proven Cell Penetration

Annals of Oncology ◽

10.1093/annonc/mdt043.3 ◽

2013 ◽

Vol 24 ◽

pp. i18

Author(s):

J. Winkler ◽

L. Burgess ◽

E. Laird ◽

D. Weaver ◽

D. Chantry

Keyword(s):

Small Molecule ◽

Small Molecule Inhibitors ◽

Phenotypic Screening ◽

Cell Penetration

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Identification of a Class of Small Molecule Inhibitors of the Sirtuin Family of NAD-dependent Deacetylases by Phenotypic Screening

Journal of Biological Chemistry ◽

10.1074/jbc.m106779200 ◽

2001 ◽

Vol 276 (42) ◽

pp. 38837-38843 ◽

Author(s):

Christina M. Grozinger ◽

Elizabeth D. Chao ◽

Helen E. Blackwell ◽

Danesh Moazed ◽

Stuart L. Schreiber

Keyword(s):

Small Molecule ◽

Small Molecule Inhibitors ◽

Phenotypic Screening

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Phenotypic Screening of Small-Molecule Inhibitors: Implications for Therapeutic Discovery and Drug Target Development in Traumatic Brain Injury

Methods in Molecular Biology - Injury Models of the Central Nervous System ◽

10.1007/978-1-4939-3816-2_37 ◽

2016 ◽

pp. 677-688 ◽

Author(s):

Hassan Al-Ali ◽

Vance P. Lemmon ◽

John L. Bixby

Keyword(s):

Traumatic Brain Injury ◽

Brain Injury ◽

Small Molecule ◽

Drug Target ◽

Small Molecule Inhibitors ◽

Phenotypic Screening

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Faculty Opinions recommendation of Identification of a class of small molecule inhibitors of the sirtuin family of NAD-dependent deacetylases by phenotypic screening.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1001247.19454 ◽

2001 ◽

Author(s):

Benjamin Cravatt

Keyword(s):

Small Molecule ◽

Small Molecule Inhibitors ◽

Phenotypic Screening

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Faculty Opinions recommendation of Identification of a class of small molecule inhibitors of the sirtuin family of NAD-dependent deacetylases by phenotypic screening.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1001247.16762 ◽

2001 ◽

Author(s):

Peter Belshaw

Keyword(s):

Small Molecule ◽

Small Molecule Inhibitors ◽

Phenotypic Screening

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From molecular diagnostics to molecular targeted therapy with natural product small molecule inhibitors in oral squamous cell carcinoma

Planta Medica ◽

10.1055/s-2007-986722 ◽

2007 ◽

Vol 73 (09) ◽

Author(s):

VB Konkimalla ◽

VL Suhas ◽

NR Chandra ◽

E Gebhart ◽

T Efferth

Keyword(s):

Squamous Cell Carcinoma ◽

Targeted Therapy ◽

Oral Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Natural Product ◽

Molecular Diagnostics ◽

Small Molecule ◽

Squamous Cell ◽

Molecular Targeted Therapy ◽

Small Molecule Inhibitors

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Faculty Opinions recommendation of Nanomolar small molecule inhibitors for alphav(beta)6, alphav(beta)5, and alphav(beta)3 integrins.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1004750.54854 ◽

2002 ◽

Author(s):

Carol Otey

Keyword(s):

Small Molecule ◽

Small Molecule Inhibitors

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Faculty Opinions recommendation of Identification of small molecule inhibitors of anthrax lethal factor.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1016978.201559 ◽

2004 ◽

Author(s):

Kristina Downing

Keyword(s):

Small Molecule ◽

Small Molecule Inhibitors ◽

Lethal Factor ◽

Anthrax Lethal Factor

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Faculty Opinions recommendation of Harnessing chaperones to generate small-molecule inhibitors of amyloid beta aggregation.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1017973.285766 ◽

2005 ◽

Author(s):

George Perry

Keyword(s):

Small Molecule ◽

Amyloid Beta ◽

Small Molecule Inhibitors

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Faculty Opinions recommendation of High-affinity small molecule inhibitors of T cell costimulation: compounds for immunotherapy.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1023153.264839 ◽

2005 ◽

Author(s):

Robert Kelley

Keyword(s):

T Cell ◽

Small Molecule ◽

Small Molecule Inhibitors ◽

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Faculty Opinions recommendation of Novel small molecule inhibitors of 3-phosphoinositide-dependent kinase-1.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1024840.292879 ◽

2005 ◽

Author(s):

Chandra Kumar

Keyword(s):

Small Molecule ◽

Small Molecule Inhibitors ◽

Phosphoinositide Dependent Kinase

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