scholarly journals Practical guidance for mismatch repair-deficiency testing in endometrial cancer

2017 ◽  
Vol 28 (1) ◽  
pp. 96-102 ◽  
Author(s):  
E. Stelloo ◽  
A.M.L. Jansen ◽  
E.M. Osse ◽  
R.A. Nout ◽  
C.L. Creutzberg ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Mismatch Repair ◽  
Mismatch Repair Deficiency ◽  
Repair Deficiency ◽  
Practical Guidance

P84 Mismatch repair deficiency as a predictive marker for response to adjuvant radiotherapy in endometrial cancer

2019 ◽  
Author(s):  
C Reijnen ◽  
H Küsters-Vandevelde ◽  
C Prinsen ◽  
L Massuger ◽  
M Snijders ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Mismatch Repair ◽  
Adjuvant Radiotherapy ◽  
Predictive Marker ◽  
Mismatch Repair Deficiency ◽  
Repair Deficiency

Clinicopathologic characteristics and outcomes of endometrial Cancer patients with mismatch repair deficiency in the era of universal Lynch syndrome screening

2020 ◽  
Vol 159 (3) ◽  
pp. 712-720
Author(s):  
Caitlin Carr ◽  
Jessica Son ◽  
Meng Yao ◽  
Anju Priyadarshini ◽  
Jessica Marquard ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Lynch Syndrome ◽  
Cancer Patients ◽  
Mismatch Repair ◽  
Mismatch Repair Deficiency ◽  
Clinicopathologic Characteristics ◽  
Repair Deficiency

Mismatch Repair Deficiency in Endometrial Cancer

2019 ◽  
Vol 27 (9) ◽  
pp. 678-682
Author(s):  
Raoudha Doghri ◽  
Yoldez Houcine ◽  
Nadia Boujelbène ◽  
Maha Driss ◽  
Lamia Charfi ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Mismatch Repair ◽  
Mismatch Repair Deficiency ◽  
Repair Deficiency

Clinical characterization of DNA mismatch repair deficiency (MMR-D) in endometrial cancer (EC).

2016 ◽  
Vol 34 (15_suppl) ◽  
pp. 1522-1522
Author(s):  
Karen Anne Cadoo ◽  
Christina Tran ◽  
Deborah DeLair ◽  
Angela G. Arnold ◽  
Asad Ashraf ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Mismatch Repair ◽  
Dna Mismatch Repair ◽  
Mismatch Repair Deficiency ◽  
Dna Mismatch ◽  
Repair Deficiency ◽  
Dna Mismatch Repair Deficiency

scholarly journals Retroactive assessment for DNA mismatch repair deficiency in women with a history of endometrial cancer

2021 ◽  
Vol 9 (4) ◽  
Author(s):  
Y. Chen ◽  
Sushmita Gordhandas ◽  
Kelsey Musselman ◽  
Zhen Zhou ◽  
Brandon Maddy ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Genetic Counseling ◽  
Genetic Testing ◽  
Mismatch Repair ◽  
Gynecologic Oncology ◽  
Molecular Classification ◽  
Pathogenic Mutation ◽  
Mismatch Repair Deficiency ◽  
Repair Deficiency ◽  
Mismatch Repair Proteins

Objectives. Beginning in 2014, the Society of Gynecologic Oncology and the American College of Obstetricians and Gynecologists have recommended universal tumor testing for mismatch repair deficiency in endometrial cancer. Mismatch repair testing can triage patients who may benefit from genetic testing for Lynch syndrome. Many women previously diagnosed with endometrial cancer have not undergone mismatch repair tumor testing. We sought to determine the feasibility of retroactive assessment for mismatch repair deficiency among women with diagnosed with endometrial cancer prior to 2014. Methods. Between 2016 and 2018, we identified 36 patients presenting for gynecologic oncology follow-up visits who were previously diagnosed with endometrial cancer. The endometrial pathology underwent tumor assessment for loss of expression of mismatch repair proteins by immunohistochemistry. Patients with abnormal mismatch repair testing were referred to genetic counseling and, if indicated, for germline genetic testing. Results. Thirty-six patients underwent retroactive tumor immunohistochemistry, yielding 10 (28%) abnormal results, including nine (25%) with loss of one or more mismatch repair proteins and one with inconclusive staining (2.8%). All ten patients with abnormal immunohistochemistry were referred to genetic counseling; 9 (90%) accepted the referral and proceeded with genetic testing. One pathogenic mutation was identified in CHEK2 (11%). Five patients (56%) were found to have a variant of unknown significance. Conclusions. Implementation of universal retroactive tumor testing for mismatch repair deficiency in patients previously diagnosed with endometrial cancer is feasible. With the growing use of new molecular classification protocols for endometrial tumors, identification of mismatch repair deficiency may have significant clinicopathologic implications.

scholarly journals Clinicopathologic features of endometrial cancer with mismatch repair deficiency

2020 ◽  
Vol 14 ◽  
Author(s):  
Sushmita Gordhandas ◽  
Ryan M Kahn ◽  
Charlotte Gamble ◽  
Nizam Talukdar ◽  
Brandon Maddy ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Mismatch Repair ◽  
Clinicopathologic Features ◽  
Mismatch Repair Deficiency ◽  
Repair Deficiency

scholarly journals Mismatch repair deficiency and aberrations in the Notch and Hedgehog pathways are of prognostic value in patients with endometrial cancer

PLoS ONE ◽  
2018 ◽  
Vol 13 (12) ◽  
pp. e0208221 ◽  
Author(s):  
Genovefa Polychronidou ◽  
Vassiliki Kotoula ◽  
Kyriaki Manousou ◽  
Ioannis Kostopoulos ◽  
Georgia Karayannopoulou ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Mismatch Repair ◽  
Prognostic Value ◽  
Mismatch Repair Deficiency ◽  
Repair Deficiency

scholarly journals Clinical problems of colorectal cancer and endometrial cancer cases with unknown cause of tumor mismatch repair deficiency (suspected Lynch syndrome)

2014 ◽  
pp. 183 ◽  
Author(s):  
Aung Ko Win ◽  
Daniel Buchanan ◽  
Christophe Rosty ◽  
Mark Clendenning ◽  
Amanda Spurdle
Keyword(s):  
Colorectal Cancer ◽  
Endometrial Cancer ◽  
Lynch Syndrome ◽  
Mismatch Repair ◽  
Mismatch Repair Deficiency ◽  
Repair Deficiency ◽  
Clinical Problems
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