Increased corn oil intake during an allergy sensitization period aggravates food allergy severity after oral allergen exposure

2021 ◽  
Author(s):  
Akihiro Maeta ◽  
Risako Katahira ◽  
Kyoko Takahashi
Keyword(s):  
Food Allergy ◽  
Oil Content ◽  
Corn Oil ◽  
Food Challenge ◽  
Egg White ◽  
Oral Immunotherapy ◽  
Allergen Exposure ◽  
Oral Food Challenge

Abstract Egg white (EW) allergy model mice underwent 15-day oral immunotherapy (OIT) using diets with different corn-oil content and 1% EW. After OIT, mortality following an oral food challenge in OIT groups were approximately 90%. However, in previous studies, mortality was 0%. This phenomenon is to be associated with increased corn-oil intake during allergy sensitization and allergen exposure for 2 weeks.

scholarly journals Billing fees for various common allergy tests vary widely across Canada

2020 ◽  
Vol 16 (1) ◽  
Author(s):  
Jennifer Lisa Penner Protudjer ◽  
Lianne Soller ◽  
Elissa Michelle Abrams ◽  
Edmond S. Chan
Keyword(s):  
Food Allergy ◽  
Response Rate ◽  
Diagnostic Testing ◽  
Food Challenge ◽  
Oral Immunotherapy ◽  
Oral Food Challenge ◽  
Canadian Society ◽  
Demographic Information ◽  
Canadian Data

Abstract Background The prevalence of food allergy in Canada is high and has increased over time. To date, there are no Canadian data on the healthcare costs of visits to allergists. Methods We sent an anonymous survey to allergist members of the Canadian Society of Allergy and Clinical Immunology (CSACI) between October and December 2019. Survey questions included demographic information and billing fees for various types of allergy visits and diagnostic testing. Results Of 200 allergists who are members of CSACI, 43 allergists responded (21.5% response rate). Billing fees varied widely. The greatest ranges were noted for oral immunotherapy (OIT; both initial consultation [mean $198.70; range $0 to $575] and follow up/build up visits [mean $125.74; range: $0 to $575]). There were significant provincial differences in billing fees, as well as significant billing fee differences between hospital versus community allergists (e.g. oral food challenge [OFC]: $256.38 vs. $134.94, p < 0.01). Billing fees were higher outside of Ontario, with the exception of specific Immunoglubulin E (sIgE) testing and OIT visits. Conclusions Greater standardization of billing fees across provinces and between hospital versus community allergy could result in more consistency of billing fees for OFC and OIT across Canada. Further knowledge of exact costs will help inform practice and policy in the diagnosis and management of food allergy.

scholarly journals Food allergy and anaphylaxis – 2054. Easy-to-use severity grading system for treatment of symptoms induced by oral food challenge

2013 ◽  
Vol 6 ◽  
pp. P137 ◽  
Author(s):  
Noriyuki Yanagida ◽  
Yuu Okada ◽  
Hasegawa Yukiko ◽  
Taro Miura ◽  
Ishida Wako ◽  
...  
Keyword(s):  
Food Allergy ◽  
Food Challenge ◽  
Oral Food Challenge ◽  
Grading System ◽  
Severity Grading

scholarly journals Oral Food Challenge and Food Allergy Quality of Life in Caregivers of Children with Food Allergy

2015 ◽  
Vol 3 (1) ◽  
pp. 50-56 ◽  
Author(s):  
Timothy J. Franxman ◽  
Laura Howe ◽  
Esther Teich ◽  
Matthew J. Greenhawt
Keyword(s):  
Quality Of Life ◽  
Food Allergy ◽  
Food Challenge ◽  
Oral Food Challenge

scholarly journals Oral immunotherapy for treatment of peanut allergy

2020 ◽  
Vol 68 (6) ◽  
pp. 1152-1155
Author(s):  
Joan H Dunlop
Keyword(s):  
Food Allergy ◽  
Peanut Allergy ◽  
Food Challenge ◽  
Oral Immunotherapy ◽  
Peanut Protein ◽  
Subcutaneous Immunotherapy ◽  
Double Blind ◽  
The Us ◽  
Allergy Prevalence

The US Food and Drug Administration’s approval of a peanut oral immunotherapy product in January 2020 is a landmark development in the field of food allergy therapy. While food allergy prevalence has been increasing, this product is the first approved therapy for food allergy. Oral immunotherapy has many similarities to subcutaneous immunotherapy and drug desensitization protocols, but does not lead to sustained unresponsiveness. The studies leading to approval of the Palforzia product demonstrated increase in the amount of peanut protein able to be consumed, with 67% of subjects randomized to the treatment arm able to consume 600 mg of peanut protein in double-blind placebo-controlled food challenge at study exit. However, side effects are an important consideration, and dropout rates in studies of Palforzia ranged from 11% to 21%. Postmarketing surveillance of this product will be critical in assessing its long-term risks and benefits.

scholarly journals Detection of Salivary Tryptase Levels in Children following Oral Food Challenges

2021 ◽  
pp. 1-4
Author(s):  
Wouter W. de Weger ◽  
Vibeke M. Bruinenberg ◽  
Evelien M. van der Lek ◽  
Jeroen H. Gerrits ◽  
Lidy van Lente ◽  
...  
Keyword(s):  
Food Allergy ◽  
Limit Of Detection ◽  
Food Challenge ◽  
Oral Food Challenge ◽  
Potential Association ◽  
The Mean ◽  
Food Challenges ◽  
Assay Precision ◽  
Objective Marker ◽  
Time Point

<b><i>Background:</i></b> Oral food challenge (OFC) is commonly used to diagnose food allergy. This test is time and resource intensive, and conclusions are not always unequivocal as this relies on the interpretation of symptoms. Therefore, an objective marker would improve the accuracy of the diagnostic workup of food allergy. <b><i>Objectives:</i></b> The aim of this study was to investigate whether tryptase can be detected in saliva of children following OFC. <b><i>Method:</i></b> Children from 3 to 18 years of age were eligible for inclusion if an OFC for peanut or tree nut had been recommended. Saliva samples were collected prior to the first dose and 5, 10, and 15 min following the last administered dose during OFC. Assay precision, spike-and-recovery, and assessment of lower limit of detection of the tryptase immunoassay were examined before analysis of tryptase in saliva was performed. <b><i>Results:</i></b> A total of 30 children were included (median age 8 years, 63.3% male, 53.3% positive OFC outcome). Tryptase was detected in saliva samples. The mean of the change in baseline tryptase value to each saliva collecting time point was significantly different in patients with a positive OFC outcome compared to a negative outcome (<i>p</i> &#x3c; 0.01). <b><i>Conclusions:</i></b> This study showed that tryptase can be detected in saliva of children following OFC. Increased levels of tryptase compared to baseline were found if the OFC outcome was positive, suggesting that measuring tryptase in saliva may be useful in the diagnosis of food allergy. Further research is needed to evaluate the potential association between tryptase levels and symptoms.

Caregiver perceptions of when to offer an oral food challenge for children with food allergy

2019 ◽  
Vol 122 (6) ◽  
pp. 660-661
Author(s):  
Monica T. Kraft ◽  
Rebecca Scherzer ◽  
Elizabeth A. Erwin ◽  
Irene Mikhail
Keyword(s):  
Food Allergy ◽  
Food Challenge ◽  
Oral Food Challenge

Oral Food Challenge: Experience in a Brazilian Food Allergy Outpatient Terciary Service

2013 ◽  
Vol 131 (2) ◽  
pp. AB83
Author(s):  
Camila Pereira ◽  
Leila Borges ◽  
Renata R. Cocco ◽  
Lucila Camargo ◽  
Marcia Mallozi ◽  
...  
Keyword(s):  
Food Allergy ◽  
Food Challenge ◽  
Oral Food Challenge
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