The Genetic Basis of Reproductive Isolation in House Mice.

2011 ◽  
Vol 85 (Suppl_1) ◽  
pp. 165-165
Author(s):  
Michael Nachman
Keyword(s):  
Reproductive Isolation ◽  
Genetic Basis ◽  
House Mice

scholarly journals PRDM9 Diversity at Fine Geographical Scale Reveals Contrasting Evolutionary Patterns and Functional Constraints in Natural Populations of House Mice

2019 ◽  
Vol 36 (8) ◽  
pp. 1686-1700 ◽  
Author(s):  
Covadonga Vara ◽  
Laia Capilla ◽  
Luca Ferretti ◽  
Alice Ledda ◽  
Rosa A Sánchez-Guillén ◽  
...  
Keyword(s):  
Reproductive Isolation ◽  
Evolutionary Biology ◽  
Evolutionary Dynamics ◽  
Rapid Evolution ◽  
Natural Populations ◽  
Global Scale ◽  
House Mice ◽  
Functional Constraints ◽  
Evolutionary Patterns ◽  
Data Set

Abstract One of the major challenges in evolutionary biology is the identification of the genetic basis of postzygotic reproductive isolation. Given its pivotal role in this process, here we explore the drivers that may account for the evolutionary dynamics of the PRDM9 gene between continental and island systems of chromosomal variation in house mice. Using a data set of nearly 400 wild-caught mice of Robertsonian systems, we identify the extent of PRDM9 diversity in natural house mouse populations, determine the phylogeography of PRDM9 at a local and global scale based on a new measure of pairwise genetic divergence, and analyze selective constraints. We find 57 newly described PRDM9 variants, this diversity being especially high on Madeira Island, a result that is contrary to the expectations of reduced variation for island populations. Our analysis suggest that the PRDM9 allelic variability observed in Madeira mice might be influenced by the presence of distinct chromosomal fusions resulting from a complex pattern of introgression or multiple colonization events onto the island. Importantly, we detect a significant reduction in the proportion of PRDM9 heterozygotes in Robertsonian mice, which showed a high degree of similarity in the amino acids responsible for protein–DNA binding. Our results suggest that despite the rapid evolution of PRDM9 and the variability detected in natural populations, functional constraints could facilitate the accumulation of allelic combinations that maintain recombination hotspot symmetry. We anticipate that our study will provide the basis for examining the role of different PRDM9 genetic backgrounds in reproductive isolation in natural populations.

scholarly journals Genetic Basis of Mating Preferences in Wild House Mice

1992 ◽  
Vol 32 (1) ◽  
pp. 40-47 ◽  
Author(s):  
SARAH LENINGTON ◽  
CAROL COOPERSMITH ◽  
JESSIE WILLIAMS
Keyword(s):  
Genetic Basis ◽  
House Mice ◽  
Mating Preferences ◽  
Wild House Mice

scholarly journals Age and genetic background determine hybrid male sterility in house mice

2018 ◽  
Author(s):  
Samuel J. Widmayer ◽  
David L. Aylor
Keyword(s):  
Reproductive Isolation ◽  
Male Sterility ◽  
Genetic Factors ◽  
Inbred Strains ◽  
House Mice ◽  
Reproductive Barriers ◽  
Hybrid Male ◽  
Hybrid Male Sterility ◽  
Unique Type ◽  
Age Dependent

AbstractHybrid male sterility (HMS) is a unique type of reproductive isolation commonly observed between house mouse (Mus musculus) subspecies in the wild and in laboratory crosses. We identified hybrids that display three distinct trajectories of fertility despite having identical genotypes at the major HMS gene Prdm9 and the X Chromosome. In each case, we crossed female PWK/PhJ mice representative of the M.m.musculus subspecies to males from classical inbred strains representative of M.m.domesticus: 129S1/SvImJ, A/J, C57BL/6J, and DBA/2J. PWK129S1 males are always sterile, while PWKDBA2 males escape HMS. In addition, we observe age-dependent sterility in PWKB6 and PWKAJ males. These males are fertile between 15 and 35 weeks with moderate penetrance. These results point to multiple segregating HMS modifier alleles, some of which have an age-dependent mode of action. Age-dependent mechanisms could have broad implications for the maintenance of reproductive barriers in nature.Author SummaryTwo subspecies of house mice show partial reproductive barriers in nature, and may be in the process of speciation. We used mice derived from each subspecies to replicate hybrid male sterility (HMS) in laboratory mice. Two major genetic factors are well established as playing a role in mouse HMS, but the number of additional factors and their mechanisms are unknown. We characterized reproductive trait variation in a set of hybrid male mice that were specifically designed to eliminate the effects of known genetic factors. We discovered that age played an important role in fertility of some hybrids. These hybrid males showed a delayed onset of fertility, then became fertile for only a few weeks. Across all hybrids males in our study, we observed three distinct trajectories of fertility: complete fertility, complete sterility, and age-dependent fertility. These results point to two or more critical HMS variants with large enough effects to completely restore fertility. This study advances our understanding of the genetic architecture and biological mechanisms of reproductive isolation in mice.

The potential for rapid speciation in plants

Genome ◽  
1989 ◽  
Vol 31 (1) ◽  
pp. 203-210 ◽  
Author(s):  
Mark R. Macnair
Keyword(s):  
Reproductive Isolation ◽  
Genetic Architecture ◽  
Genetic Basis ◽  
Natural Populations ◽  
Direct Result ◽  
Epistatic Interactions ◽  
Genetic Changes ◽  
Rapid Speciation ◽  
Genetic Revolution ◽  
Self Fertilization

Speciation involves both ecological adaptation and reproductive isolation. This paper reviews various ways in which plants could achieve reproductive isolation as a direct result of adaptation to prevailing conditions, particularly through changes in flowering time, the adoption of self-fertilization, and changes in flower morphology so that different pollinators are attracted. These characters are likely to have a relatively simple genetic architecture, and there must frequently be genetic variance for them in natural populations. It is argued that speciation could thus be initiated swiftly in plants, without any need for a "genetic revolution" or the fixation of genes with strongly epistatic interactions. Postmating barriers also often have a simple genetic basis in plants, and so could also evolve swiftly if associated with an adaptive response. The nature of the genetic changes associated with speciation in a number of recent speciation events in Layia, Stephanomeria, and Mimulus is reviewed.Key words: Speciation, adaptation, reproductive isolation.

scholarly journals The Genetic Basis of Prezygotic Reproductive Isolation Between Drosophila santomea and D. yakuba Due to Mating Preference

Genetics ◽  
2006 ◽  
Vol 173 (1) ◽  
pp. 215-223 ◽  
Author(s):  
Amanda J. Moehring ◽  
Ana Llopart ◽  
Susannah Elwyn ◽  
Jerry A. Coyne ◽  
Trudy F. C. Mackay
Keyword(s):  
Reproductive Isolation ◽  
Genetic Basis ◽  
Mating Preference

scholarly journals Sympatric, parapatric or allopatric: the most important way to classify speciation?

2008 ◽  
Vol 363 (1506) ◽  
pp. 2997-3007 ◽  
Author(s):  
Roger K Butlin ◽  
Juan Galindo ◽  
John W Grahame
Keyword(s):  
Reproductive Isolation ◽  
Local Adaptation ◽  
Genetic Basis ◽  
Environmental Gradients ◽  
Sympatric Speciation ◽  
Model System ◽  
Littorina Saxatilis ◽  
The Past ◽  
Intertidal Gastropod

The most common classification of modes of speciation begins with the spatial context in which divergence occurs: sympatric, parapatric or allopatric. This classification is unsatisfactory because it divides a continuum into discrete categories, concentrating attention on the extremes, and it subordinates other dimensions on which speciation processes vary, such as the forces driving differentiation and the genetic basis of reproductive isolation. It also ignores the fact that speciation is a prolonged process that commonly has phases in different spatial contexts. We use the example of local adaptation and partial reproductive isolation in the intertidal gastropod Littorina saxatilis to illustrate the inadequacy of the spatial classification of speciation modes. Parallel divergence in shell form in response to similar environmental gradients in England, Spain and Sweden makes this an excellent model system. However, attempts to demonstrate ‘incipient’ and ‘sympatric’ speciation involve speculation about the future and the past. We suggest that it is more productive to study the current balance between local adaptation and gene flow, the interaction between components of reproductive isolation and the genetic basis of differentiation.

scholarly journals The Genetic Basis of Inbreeding Avoidance in House Mice

2007 ◽  
Vol 17 (23) ◽  
pp. 2061-2066 ◽  
Author(s):  
Amy L. Sherborne ◽  
Michael D. Thom ◽  
Steve Paterson ◽  
Francine Jury ◽  
William E.R. Ollier ◽  
...  
Keyword(s):  
Genetic Basis ◽  
Inbreeding Avoidance ◽  
House Mice

scholarly journals Conspecific sperm precedence is reinforced but sexual selection weakened in sympatric populations ofDrosophila

2016 ◽  
Author(s):  
Dean M. Castillo ◽  
Leonie C. Moyle
Keyword(s):  
Sexual Selection ◽  
Reproductive Isolation ◽  
Sperm Competition ◽  
Competitive Ability ◽  
Genetic Basis ◽  
Direct Selection ◽  
Sperm Precedence ◽  
Sympatric Populations ◽  
Selection For ◽  
The Cost

SUMMARYSexual selection is well recognized as a driver of reproductive isolation between lineages. However, selection for increased reproductive isolation could reciprocally change the outcomes of sexual selection, when these processes share a genetic basis. Direct selection for reproductive isolation occurs in the context of ‘reinforcement’, where selection acts to increase prezygotic barriers to reduce the cost of heterospecific matings. Many studies of reinforcement focus on premating reproductive barriers, however postmating traits-such as conspecific sperm precedence (CSP)-can also respond to reinforcing selection. We tested whether i) CSP responded to reinforcing selection, and ii) this response in sympatric populations altered intraspecific sperm competition (ISC) and the strength of sexual selection, with the sister speciesDrosophila pseudoobscuraandD. persimilis. We used sperm competition experiments to evaluate differences in CSP and ISC between two sympatric and two allopatric populations ofD. pseudoobscura. Using multiple genotypes for each population allowed us to estimate not only patterns of phenotype divergence, but also the opportunity for sexual selection within each population. Consistent with a pattern of reinforcement, the sympatric populations had higher mean CSP. Moreover, ISC was altered in sympatric populations, where we observed decreased average offensive sperm competitive ability against conspecific males, allowing less opportunity for sexual selection to operate within these populations. These data demonstrate that strong reinforcing selection for reproductive isolation can have consequences for sexual selection and sexual interactions within species, in these important postmating sperm competition traits.

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