The basal ganglia and inhibitory mechanisms in response selection: evidence from subliminal priming of motor responses in Parkinson’s disease

The aim of the present study was to specify the involvement of the basal ganglia in motor response selection and response inhibition. Two samples were studied. The first sample consisted of patients diagnosed with Parkinson's disease (PD) who received deep-brain stimulation (DBS) of the subthalamic nucleus (STN). The second sample consisted of patients who received DBS for the treatment of PD or essential tremor (ET) in the ventral intermediate nucleus of the thalamus (Vim). Stop-signal task and go/no-go task performances were studied in both groups. Both groups performed these tasks with (on stimulation) and without (off stimulation) DBS to address the question of whether stimulation is effective in improving choice reaction time (RT) and stop-signal RT. The results show that DBS of the STN was associated with significantly enhanced inhibitory control, as indicated by shorter stop-signal RTs. An additional finding is that DBS of the STN led to significantly shorter choice RT. The effects of DBS on responding and response inhibition were functionally independent. Although DBS of the Vim did not systematically affect task performance in patients with ET, a subgroup of Vim-stimulated PD patients showed enhanced stop-signal RTs in on stimulation versus off stimulation. This result suggests that the change in performance to stop signals may not be directly related to STN function, but rather results from a change in PD function due to DBS in general. The findings are discussed in terms of current functional and neurobiological models that relate basal ganglia function to the selection and inhibition of motor responses.

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Dopamine, Parkinson's disease, and volition

Behavioral and Brain Sciences ◽

10.1017/s0140525x02300104 ◽

2002 ◽

Vol 25 (5) ◽

pp. 586-586 ◽

Cited By ~ 3

Author(s):

Jon C. Horvitz

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Basal Ganglia ◽

Response Selection ◽

Dopamine Transmission ◽

Goal Representation ◽

External Stimuli ◽

Internal Generation

Disruptions in dopamine transmission within the basal ganglia (BG) produce deficits in voluntary actions, that is, in the interface between cortically-generated goal representation and BG-mediated response selection. Under conditions of dopamine loss in humans and other animals, responses are impaired when they require internal generation, but are relatively intact when elicited by external stimuli.

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Changes in metabotropic glutamate receptor expression in the basal ganglia of Parkinson's disease models

Neuroscience Research ◽

10.1016/s0168-0102(00)81571-0 ◽

2000 ◽

Vol 38 ◽

pp. S121

Author(s):

M Takada

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Basal Ganglia ◽

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Receptor Expression ◽

Disease Models ◽

Metabotropic Glutamate

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SPECT-Befunde bei Hemiparkinson-Syndrom mit 99mTc-HMPAO

Nuklearmedizin ◽

10.1055/s-0038-1629476 ◽

1989 ◽

Vol 28 (03) ◽

pp. 92-94 ◽

Cited By ~ 1

Author(s):

C. Neumann ◽

H. Baas ◽

R. Hefner ◽

G. Hör

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Basal Ganglia ◽

Neuronal Activity ◽

Tracer Uptake ◽

The Body ◽

99Mtc Hmpao ◽

Do So

The symptoms of Parkinson’s disease often begin on one side of the body and continue to do so as the disease progresses. First SPECT results in 4 patients with hemiparkinsonism using 99mTc-HMPAO as perfusion marker are reported. Three patients exhibited reduced tracer uptake in the contralateral basal ganglia One patient who was under therapy for 1 year, showed a different perfusion pattern with reduced uptake in both basal ganglia. These results might indicate reduced perfusion secondary to reduced striatal neuronal activity.

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Potassium channels in the basal ganglia: Promising new targets for the treatment of Parkinson's disease

Frontiers in Bioscience ◽

10.2741/2959 ◽

2008 ◽

Vol Volume (13) ◽

pp. 3685 ◽

Cited By ~ 1

Author(s):

Gang Wang

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Basal Ganglia ◽

Potassium Channels ◽

New Targets

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Corticostriatal Plastic Changes in Experimental L-DOPA-Induced Dyskinesia

Parkinson s Disease ◽

10.1155/2012/358176 ◽

2012 ◽

Vol 2012 ◽

pp. 1-10 ◽

Cited By ~ 3

Author(s):

Veronica Ghiglieri ◽

Vincenza Bagetta ◽

Valentina Pendolino ◽

Barbara Picconi ◽

Paolo Calabresi

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Basal Ganglia ◽

Experimental Models ◽

Striatal Neurons ◽

Da Receptors ◽

Electrophysiological Studies ◽

Plastic Changes ◽

Stimulation Of

In Parkinson’s disease (PD), alteration of dopamine- (DA-) dependent striatal functions and pulsatile stimulation of DA receptors caused by the discontinuous administration of levodopa (L-DOPA) lead to a complex cascade of events affecting the postsynaptic striatal neurons that might account for the appearance of L-DOPA-induced dyskinesia (LID). Experimental models of LID have been widely used and extensively characterized in rodents and electrophysiological studies provided remarkable insights into the inner mechanisms underlying L-DOPA-induced corticostriatal plastic changes. Here we provide an overview of recent findings that represent a further step into the comprehension of mechanisms underlying maladaptive changes of basal ganglia functions in response to L-DOPA and associated to development of LID.

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