scholarly journals Exacerbation of C1q dysregulation, synaptic loss and memory deficits in tau pathology linked to neuronal adenosine A2A receptor

Brain ◽  
2019 ◽  
Vol 142 (11) ◽  
pp. 3636-3654 ◽  
Author(s):  
Kevin Carvalho ◽  
Emilie Faivre ◽  
Marie J Pietrowski ◽  
Xavier Marques ◽  
Victoria Gomez-Murcia ◽  
...  
Keyword(s):  
Cognitive Deficits ◽  
Memory Deficits ◽  
Immune Dysregulation ◽  
Tau Pathology ◽  
Glutamatergic Synapses ◽  
Adenosine A2a Receptors ◽  
Synaptic Loss ◽  
A2a Receptors ◽  
A2a Receptor ◽  
Adenosine A2a

See Cunha (doi:10.1093/brain/awz335) for a scientific commentary on this article. Carvalho et al. provide clues to the onset of immune dysregulation underlying early synaptic loss in Alzheimer’s disease and tauopathies, by linking overactivation of adenosine A2A receptors in tau pathology to a particular microglial signature (upregulation of C1q and TREM2) allied to the loss of glutamatergic synapses and cognitive deficits.

scholarly journals Overactivity of neuronal adenosine A2A receptors accelerates neurodegeneration

Brain ◽  
2019 ◽  
Vol 142 (11) ◽  
pp. 3323-3324 ◽  
Author(s):  
Rodrigo A Cunha
Keyword(s):  
Memory Deficits ◽  
Tau Pathology ◽  
Adenosine A2a Receptors ◽  
Synaptic Loss ◽  
A2a Receptors ◽  
Adenosine A2a

This scientific commentary refers to ‘Exacerbation of C1q dysregulation, synaptic loss and memory deficits in tau pathology linked to neuronal adenosine A2A receptors’, by Carvalho et al. (doi:10.1093/brain/awz288).

scholarly journals Region-specific control of microglia by adenosine A2A receptors: uncoupling anxiety and associated cognitive deficits in female rats

Glia ◽  
2018 ◽  
Vol 67 (1) ◽  
pp. 182-192 ◽  
Author(s):  
Joana Mendes Duarte ◽  
Rita Gaspar ◽  
Liliana Caetano ◽  
Patrícia Patrício ◽  
Carina Soares-Cunha ◽  
...  
Keyword(s):  
Cognitive Deficits ◽  
Female Rats ◽  
Adenosine A2a Receptors ◽  
A2a Receptors ◽  
Adenosine A2a ◽  
Specific Control

scholarly journals Adenosine A2A Receptors and A2A Receptor Heteromers as Key Players in Striatal Function

2011 ◽  
Vol 5 ◽  
Author(s):  
Sergi Ferré ◽  
César Quiroz ◽  
Marco Orru ◽  
Xavier Guitart ◽  
Gemma Navarro ◽  
...  
Keyword(s):  
Adenosine A2a Receptors ◽  
A2a Receptors ◽  
Receptor Heteromers ◽  
A2a Receptor ◽  
Key Players ◽  
Adenosine A2a ◽  
Striatal Function

scholarly journals How Are Adenosine and Adenosine A2A Receptors Involved in the Pathophysiology of Amyotrophic Lateral Sclerosis?

Biomedicines ◽  
2021 ◽  
Vol 9 (8) ◽  
pp. 1027
Author(s):  
Akihisa Mori ◽  
Brittany Cross ◽  
Shinichi Uchida ◽  
Jill Kerrick Walker ◽  
Robert Ristuccia
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Motor Neurons ◽  
Clinical Pathology ◽  
Adenosine A2a Receptors ◽  
Receptor Antagonism ◽  
Beneficial Effects ◽  
A2a Receptors ◽  
A2a Receptor ◽  
Adenosine A2a ◽  
Lateral Sclerosis

Adenosine is extensively distributed in the central and peripheral nervous systems, where it plays a key role as a neuromodulator. It has long been implicated in the pathogenesis of progressive neurogenerative disorders such as Parkinson’s disease, and there is now growing interest in its role in amyotrophic lateral sclerosis (ALS). The motor neurons affected in ALS are responsive to adenosine receptor function, and there is accumulating evidence for beneficial effects of adenosine A2A receptor antagonism. In this article, we focus on recent evidence from ALS clinical pathology and animal models that support dynamism of the adenosinergic system (including changes in adenosine levels and receptor changes) in ALS. We review the possible mechanisms of chronic neurodegeneration via the adenosinergic system, potential biomarkers and the acute symptomatic pharmacology, including respiratory motor neuron control, of A2A receptor antagonism to explore the potential of the A2A receptor as target for ALS therapy.

Working memory deficits in transgenic rats overexpressing human adenosine A2A receptors in the brain

2007 ◽  
Vol 87 (1) ◽  
pp. 42-56 ◽  
Author(s):  
Lydia Giménez-Llort ◽  
Serge N. Schiffmann ◽  
Tanja Shmidt ◽  
Laia Canela ◽  
Lluïsa Camón ◽  
...  
Keyword(s):  
Working Memory ◽  
Memory Deficits ◽  
Adenosine A2a Receptors ◽  
Transgenic Rats ◽  
A2a Receptors ◽  
Adenosine A2a ◽  
The Brain

Adenosine A2A receptors are involved in physical dependence and place conditioning induced by THC

2004 ◽  
Vol 20 (8) ◽  
pp. 2203-2213 ◽  
Author(s):  
Guadalupe Soria ◽  
Anna Castane ◽  
Fernando Berrendero ◽  
Catherine Ledent ◽  
Marc Parmentier ◽  
...  
Keyword(s):  
Physical Dependence ◽  
Place Conditioning ◽  
Adenosine A2a Receptors ◽  
A2a Receptors ◽  
Adenosine A2a

scholarly journals A Crucial Role for Forebrain Adenosine A2A Receptors in Amphetamine Sensitization

2004 ◽  
Vol 30 (5) ◽  
pp. 891-900 ◽  
Author(s):  
Elena Bastia ◽  
Yue-Hang Xu ◽  
Angela C Scibelli ◽  
Yuan-Ji Day ◽  
Joel Linden ◽  
...  
Keyword(s):  
Crucial Role ◽  
Adenosine A2a Receptors ◽  
A2a Receptors ◽  
Adenosine A2a ◽  
Amphetamine Sensitization

THE ROLE OF ADENOSINE A2A RECEPTORS IN THE NEUROLEPTIC-INDUCED c-Fos EXPRESSION

1998 ◽  
Vol 9 (Supplement) ◽  
pp. S93
Author(s):  
J. Wardasa ◽  
A. Pinna ◽  
A. Cozzolino ◽  
M. Morellib
Keyword(s):  
Adenosine A2a Receptors ◽  
A2a Receptors ◽  
Fos Expression ◽  
Adenosine A2a
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