scholarly journals β2-Adrenergic receptor agonists ameliorate the adverse effect of long-term pyridostigmine on neuromuscular junction structure

Brain ◽  
2019 ◽  
Vol 142 (12) ◽  
pp. 3713-3727 ◽  
Author(s):  
An E Vanhaesebrouck ◽  
Richard Webster ◽  
Susan Maxwell ◽  
Pedro M Rodriguez Cruz ◽  
Judith Cossins ◽  
...  
Keyword(s):  
Adverse Effect ◽  
Neuromuscular Junction ◽  
Adrenergic Receptor ◽  
Deficiency Syndrome ◽  
Receptor Agonists ◽  
Β2 Adrenergic Receptor ◽  
Beta 2 ◽  
Junction Structure ◽  
Over Time

The efficacy of anticholinesterase medication may diminish over time. Vanhaesebrouck et al. use an animal model of acetylcholine receptor deficiency syndrome to show that beta-2 adrenergic receptor agonists ameliorate the damage to neuromuscular junction structure caused by prolonged anticholinesterase medication, and thereby counteract the decline in efficacy.

Selected Contribution: Long-term effects of β2-adrenergic receptor stimulation on alveolar fluid clearance in mice

2002 ◽  
Vol 93 (5) ◽  
pp. 1875-1880 ◽  
Author(s):  
C. Sartori ◽  
X. Fang ◽  
D. W. McGraw ◽  
P. Koch ◽  
M. E. Snider ◽  
...  
Keyword(s):  
Adrenergic Receptor ◽  
Fluid Transport ◽  
Alveolar Fluid Clearance ◽  
Camp Production ◽  
Long Term Effects ◽  
Agonist Stimulation ◽  
Β2 Adrenergic Receptor ◽  
Stimulation Of ◽  
Alveolar Edema

Stimulation of active fluid transport with β-adrenergic receptor (βAR) agonists can accelerate the resolution of alveolar edema. However, chronic βAR-agonist administration may cause βAR desensitization and downregulation that may impair physiological responsiveness to βAR-agonist stimulation. Therefore, we measured baseline and terbutaline- (10−3 M) stimulated alveolar fluid clearance in mice that received subcutaneously (miniosmotic pumps) either saline or albuterol (2 mg · kg−1 · day−1) for 1, 3, or 6 days. Continuous albuterol administration increased plasma albuterol levels (10−5 M), an effect that was associated with 1) a significant decrease in βAR density and 2) attenuation, but not ablation, of maximal terbutaline-induced cAMP production. Forskolin-mediated cAMP-release was unaffected. Continuous albuterol infusion stimulated alveolar fluid clearance on day 1 but did not increase alveolar fluid clearance on days 3 and 6. However, terbutaline-stimulated alveolar fluid clearance in albuterol-treated mice was not reduced compared with saline-treated mice. Despite significant reductions in βAR density and agonist-mediated cAMP production by long-term βAR-agonist exposure, maximal βAR-agonist-mediated increase in alveolar fluid clearance is not diminished in mice.

Abstract 724: Selective β2-adrenergic receptor agonists inhibit the proliferation of 1321N1 astrocytoma cells

2010 ◽  
Author(s):  
Irving W. Wainer ◽  
Lawrence Toll ◽  
Lucita Jimenez ◽  
Willma Polgar ◽  
Carol Green ◽  
...  
Keyword(s):  
Adrenergic Receptor ◽  
Receptor Agonists ◽  
Astrocytoma Cells ◽  
Β2 Adrenergic Receptor ◽  
1321N1 Astrocytoma

scholarly journals PP2A Activation by β2-Adrenergic Receptor Agonists

2003 ◽  
Vol 278 (25) ◽  
pp. 22555-22562 ◽  
Author(s):  
Christine E. Pullar ◽  
Jin Chen ◽  
R. Rivkah Isseroff
Keyword(s):  
Adrenergic Receptor ◽  
Receptor Agonists ◽  
Β2 Adrenergic Receptor ◽  
Pp2a Activation

scholarly journals β2-Adrenergic Receptor Agonists Inhibit the Proliferation of 1321N1 Astrocytoma Cells

2010 ◽  
Vol 336 (2) ◽  
pp. 524-532 ◽  
Author(s):  
L. Toll ◽  
L. Jimenez ◽  
N. Waleh ◽  
K. Jozwiak ◽  
A.Y.-H. Woo ◽  
...  
Keyword(s):  
Adrenergic Receptor ◽  
Receptor Agonists ◽  
Astrocytoma Cells ◽  
Β2 Adrenergic Receptor ◽  
1321N1 Astrocytoma
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