Carcinoma formation in NMRI mouse skin painting studies is a process suggesting greater than two stages

1995 ◽  
Vol 16 (1) ◽  
pp. 53-59 ◽  
Author(s):  
Annette Kopp-Schneider ◽  
Christopher J. Portier
Keyword(s):  
Mouse Skin ◽  
Nmri Mouse ◽  
Two Stages ◽  
Skin Painting

SKH-1 mouse skin painting: A short-term assay to evaluate the tumorigenic activity of cigarette smoke condensate

2010 ◽  
Vol 192 (2) ◽  
pp. 155-161 ◽  
Author(s):  
E. Roemer ◽  
T.H. Ottmueller ◽  
H.-J. Urban ◽  
C. Baillet-Mignard
Keyword(s):  
Cigarette Smoke ◽  
Mouse Skin ◽  
Cigarette Smoke Condensate ◽  
Short Term ◽  
Tumorigenic Activity ◽  
Skin Painting

Stimulatory role of transforming growth factors in multistage skin carcinogenesis: Possible explanation for the tumor-inducing effect of wounding in initiated nmri mouse skin

1989 ◽  
Vol 43 (5) ◽  
pp. 915-921 ◽  
Author(s):  
Gerhard Förstenberger ◽  
Michael Rogers ◽  
Ruben Schnapke ◽  
Georg Bauer ◽  
Petra Höufler ◽  
...  
Keyword(s):  
Growth Factors ◽  
Mouse Skin ◽  
Skin Carcinogenesis ◽  
Nmri Mouse ◽  
Transforming Growth Factors

scholarly journals The genotoxic air pollutant 3-nitrobenzanthrone and its reactive metabolite N-hydroxy-3-aminobenzanthrone lack initiating and complete carcinogenic activity in NMRI mouse skin

2009 ◽  
Vol 284 (1) ◽  
pp. 21-29 ◽  
Author(s):  
Heinz H. Schmeiser ◽  
Gerhard Fürstenberger ◽  
Takeji Takamura-Enya ◽  
David H. Phillips ◽  
Volker M. Arlt
Keyword(s):  
Mouse Skin ◽  
Air Pollutant ◽  
Nmri Mouse ◽  
Reactive Metabolite ◽  
Carcinogenic Activity

scholarly journals The Role of Skin Painting in Predicting Lung Cancer

2007 ◽  
Vol 26 (4) ◽  
pp. 345-351 ◽  
Author(s):  
Z. Walaszek ◽  
M. Hanausek ◽  
T. J. Slaga
Keyword(s):  
Lung Cancer ◽  
Squamous Cell ◽  
Tobacco Smoke ◽  
Precancerous Lesions ◽  
Mouse Skin ◽  
Practical Method ◽  
Tumor Formation ◽  
Test Method ◽  
Epithelial Cancers ◽  
Skin Painting

The mouse skin cancer model provides an important system for studying mechanisms involved in the various stages of carcinogenesis and for bioassaying tobacco smoke constituents and additives for carcinogenic/cocarcinogenic and tumor-promoting properties as well as for identifying compounds that may inhibit tumor formation and malignant conversion. In addition, it is an excellent model for studying the formation of precancerous lesions as well as squamous cell carcinomas. It relates very well to other squamous cell carcinoma models and contributes to better understanding of the human epithelial cancers including lung cancer. The SENCAR mouse is an established model system demonstrated to be more sensitive than the B6C3F1 or Swiss CD-1 strains in the initiation/promotion skin-painting test method. Although the relationship between mouse skin tumors and any manifestation of the toxicity of tobacco smoke and other complex environmental mixtures in humans is unknown, the skin-painting model is the only assay that provides a practical method of obtaining a tumorigenic end point with cigarette smoke condensates and other complex mixtures. This assay provides a rapid response with relative ease of quantification of various parameters of tumorigenic response including tumor incidence, latency, multiplicity, and malignancy.

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