scholarly journals Development and Validation of a Sensitive and Rapid Method to Determine Naratriptan in Human Plasma by LC-ESI-MS-MS: Application to a Bioequivalence Study

2011 ◽  
Vol 49 (2) ◽  
pp. 101-107 ◽  
Author(s):  
M. Yadav ◽  
C. Patel ◽  
M. Patel ◽  
T. Mishra ◽  
P. Singhal ◽  
...  
Keyword(s):  
Human Plasma ◽  
Rapid Method ◽  
Bioequivalence Study ◽  
Esi Ms ◽  
Development And Validation

Development and validation of a UPLC-ESI-MS/MS method for the determination of N-butylscopolamine in human plasma: Application to a bioequivalence study

2012 ◽  
Vol 4 (3-4) ◽  
pp. 215-221 ◽  
Author(s):  
Wagner Alex Jann Favreto ◽  
Ana Maria Pugens Pinto ◽  
Josélia Larger Manfio ◽  
Karina Graziella Fiametti ◽  
Maycon Fernando Percio ◽  
...  
Keyword(s):  
Human Plasma ◽  
Bioequivalence Study ◽  
Esi Ms ◽  
Development And Validation

scholarly journals Development and Validation of an LC–ESI-MS Method for Quantitative Determination of Aripiprazole in Human Plasma and an Application to Pharmacokinetic Study

2012 ◽  
Vol 50 (10) ◽  
pp. 893-901 ◽  
Author(s):  
Sreedasyam Ravinder ◽  
Akula Tukaram Bapuji ◽  
Khagga Mukkanti ◽  
Datla Rama Raju ◽  
Hamsa Laxmi Venkata Ravikiran ◽  
...  
Keyword(s):  
Quantitative Determination ◽  
Human Plasma ◽  
Pharmacokinetic Study ◽  
Esi Ms ◽  
Development And Validation

scholarly journals Development of a sensitive and rapid method for quantitation of ( S )-(−)- and ( R )-(+)-metoprolol in human plasma by chiral LC–ESI–MS/MS

2014 ◽  
Vol 4 (1) ◽  
pp. 63-79 ◽  
Author(s):  
Primal Sharma ◽  
Pritesh Contractor ◽  
Swati Guttikar ◽  
Daxesh P. Patel ◽  
Pranav S. Shrivastav
Keyword(s):  
Human Plasma ◽  
Rapid Method ◽  
Esi Ms ◽  
Chiral Lc

scholarly journals Bioanalytical Method Development and Validation of Memantine in Human Plasma by High Performance Liquid Chromatography with Tandem Mass Spectrometry: Application to Bioequivalence Study

2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
Ravi Kumar Konda ◽  
B. R. Challa ◽  
Babu Rao Chandu ◽  
Kothapalli B. Chandrasekhar
Keyword(s):  
Human Plasma ◽  
High Performance ◽  
Method Development ◽  
Dynamic Range ◽  
Quantitative Estimation ◽  
Multiple Reaction Monitoring ◽  
Internal Standard ◽  
Bioequivalence Study ◽  
Healthy Human ◽  
Development And Validation

A simple, sensitive, and rapid HPLC-MS/MS method was developed and validated for quantitative estimation of memantine in human plasma. Chromatography was performed on Zorbax SB-C18(4.6×75 mm, 3.5 μm) column. Memantine (ME) and internal standard Memantine-d6(MED6) were extracted by using liquid-liquid extraction and analyzed by LC-ESI-MS/MS using multiple-reaction monitoring (MRM) mode. The assay exhibited a linear dynamic range of 50.00–50000.00 pg/ml for ME in human plasma. This method demonstrated an intra- and interday precision within the range of 2.1–3.7 and 1.4–7.8%, respectively. Further intra- and interday accuracy was within the range of 95.6–99.8 and 95.7–99.1% correspondingly. The mean recovery of ME and MED6 was86.07±6.87and80.31±5.70%, respectively. The described method was successfully employed in bioequivalence study of ME in Indian male healthy human volunteers under fasting conditions.

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