scholarly journals Development of a sensitive and rapid method for quantitation of ( S )-(−)- and ( R )-(+)-metoprolol in human plasma by chiral LC–ESI–MS/MS

2014 ◽  
Vol 4 (1) ◽  
pp. 63-79 ◽  
Author(s):  
Primal Sharma ◽  
Pritesh Contractor ◽  
Swati Guttikar ◽  
Daxesh P. Patel ◽  
Pranav S. Shrivastav
Keyword(s):  
Human Plasma ◽  
Rapid Method ◽  
Esi Ms ◽  
Chiral Lc

A rapid method for identification and quantification of prostaglandins in cerebral tissues by UHPLC-ESI-MS/MS for the lipidomic in vivo studies

2018 ◽  
Vol 545 ◽  
pp. 98-103 ◽  
Author(s):  
Luciana Assis Gobo ◽  
Leandro Machado de Carvalho ◽  
Fernanda Temp ◽  
Carine Viana ◽  
Carlos Fernando Mello
Keyword(s):  
Rapid Method ◽  
In Vivo Studies ◽  
Esi Ms ◽  
Identification And Quantification

An Improved LC-ESI-MS/MS Method to Quantify Pregabalin in Human Plasma and Dry Plasma Spot for Therapeutic Monitoring and Pharmacokinetic Applications

2018 ◽  
Vol 40 (5) ◽  
pp. 610-619 ◽  
Author(s):  
Jaya Dwivedi ◽  
Kuldeep K. Namdev ◽  
Deepak C. Chilkoti ◽  
Surajpal Verma ◽  
Swapnil Sharma
Keyword(s):  
Human Plasma ◽  
Therapeutic Monitoring ◽  
Esi Ms

Quantitation of ivosidenib in human plasma via LC–MS/MS and its application in clinical trials

Bioanalysis ◽  
2021 ◽  
Author(s):  
Feng Yin ◽  
Shaoxia Yu ◽  
Rohini Narayanaswamy ◽  
Heidi Mangus ◽  
Erin McCourt ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Human Plasma ◽  
Internal Standard ◽  
Clinical Samples ◽  
Isocitrate Dehydrogenase 1 ◽  
Bioanalytical Method ◽  
Molecule Inhibitor ◽  
Chiral Lc ◽  
First Time

Aim: Ivosidenib is a potent and selective small molecule inhibitor of mutant isocitrate dehydrogenase 1. Accurate measurement of ivosidenib is the key to ivosidenib pharmacokinetics in clinical trials. Materials & methods: Quantitation of ivosidenib was conducted by using a stable isotope labeled compound (ivosidenib-d4) as the internal standard. Results: This assay was validated and successfully applied to support multiple clinical trials. Selected clinical samples were also tested by a chiral LC–MS/MS method against four ivosidenib isomer standards to exclude the possibility of in vivo racemization of ivosidenib. Conclusion: A robust LC–MS/MS method was validated for ivosidenib in human plasma. This is the first time for ivosidenib bioanalytical method in any human matrix to be reported.

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