Serum LD-1 activity in suspected acute myocardial infarction.

1983 ◽  
Vol 29 (6) ◽  
pp. 1057-1060 ◽  
Author(s):  
W Gerhardt ◽  
S Hofvendahl ◽  
L Ljungdahl ◽  
J Waldenström ◽  
N Tryding ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Lactate Dehydrogenase ◽  
Diagnostic Value ◽  
Suspected Acute Myocardial Infarction

Abstract We have studied the diagnostic value of measuring lactate dehydrogenase (LD) isoenzyme 1 in serum of 331 cases of suspected acute myocardial infarction (AMI). At a discriminatory level of 200 U/L (Scandinavian Committee on Enzymes, recommended method for the determination of LD) LD 1 verified the diagnosis in 96% of the AMI cases and excluded it in 96% of the not-AMI cases when samples were drawn 24-72 h after onset of pain. The correlation between 24-h S-LD-1 and 16-h S-CK B activities was 0.94 in the AMI cases. We found that quantitation of serum LD-1 is diagnostically more reliable than the serum LD-1/LD ratio.

Information induction for predicting acute myocardial infarction.

1988 ◽  
Vol 34 (10) ◽  
pp. 2031-2038 ◽  
Author(s):  
R A Rudolph ◽  
L H Bernstein ◽  
J Babb
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Information Theory ◽  
Creatine Kinase ◽  
Lactate Dehydrogenase ◽  
Noisy Channel ◽  
Information Uncertainty ◽  
Test Results ◽  
Creatine Kinase Mb

Abstract We show how to make an unsupervised discrimination of disease and nondisease states by measuring information and using newer notions of inductive reason. We also present a new theory of group-based reference values that is based on measuring information uncertainty. We use data on the isoenzymes creatine kinase-MB (CK-MB) and lactate dehydrogenase-1 (LD1) and on the percentage of LD1 from 101 patients with acute myocardial infarction (AMI) and from 41 patients with suspected, but unfounded, infarction (non-AMI). Calculating the Shannon entropy, a concept from information theory, of the data base allows determination of a difference in entropy values ("effective information"), which determines decision cutoff values that produce binary-base patterns yielding the fewest classification errors. Redundancy in testing is important because it provides the information to approach a goal of errorless discrimination by coding the test results and meeting the conditions of the "Noisy Channel Theorem" of information theory. This redundancy improves the predictive value of diagnosis by isolating the area of equivocation to evident patterns. Results for CK-MB and LD1 are 99% correct in assigning cases to AMI and non-AMI categories; adding %LD1 increases the proportion of errorless binary patterns from 25% to 90%.

Zinc concentrations in serum as related to myocardial infarction.

1980 ◽  
Vol 26 (12) ◽  
pp. 1660-1661 ◽  
Author(s):  
J Lekakis ◽  
A Kalofoutis
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Lactate Dehydrogenase ◽  
Linear Correlation ◽  
Enzyme Activities ◽  
Prognostic Value ◽  
Zinc Concentration ◽  
Diagnostic Value ◽  
Cardiac Enzymes ◽  
Zinc Concentrations

Abstract Zinc concentrations in serum from 99 patients with acute myocardial infarction were correlated with the incidence of further complications and with activities in serum of the "cardiac" enzymes aspartate aminotransferase and lactate dehydrogenase. A significantly subnormal zinc concentration was observed for the patients, the lowest values being observed on the second and third days after infarct, particularly in patients with serious complications. Moreover, a linear correlation was observed between zinc values and enzyme activities until the fourth day after infarct. We conclude that measurement of zinc in the serum may have diagnostic value for acute myocardial infarction, although its prognostic value is still speculative.

DETermination of the role of OXygen in suspected Acute Myocardial Infarction trial

2014 ◽  
Vol 167 (3) ◽  
pp. 322-328 ◽  
Author(s):  
Robin Hofmann ◽  
Stefan K. James ◽  
Leif Svensson ◽  
Nils Witt ◽  
Mats Frick ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Suspected Acute Myocardial Infarction

Lactate dehydrogenase isoenzyme-1: changes during the first day after acute myocardial infarction.

1981 ◽  
Vol 27 (11) ◽  
pp. 1821-1823 ◽  
Author(s):  
D E Bruns ◽  
J C Emerson ◽  
S Intemann ◽  
R Bertholf ◽  
K E Hill ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Lactate Dehydrogenase ◽  
Time Course ◽  
False Positive Rate ◽  
Diagnostic Value ◽  
Immunochemical Method ◽  
Dehydrogenase Isoenzyme ◽  
Positive Rate ◽  
Hospital Days

Abstract We studied the time course of change of lactate dehydrogenase isoenzyme-1 (LD-1) in serum of patients suspected of having had an acute myocardial infarction. LD-1 was measured at intervals of 4-8 h during the first and second hospital days, by an immunochemical method. Of the 65 patients in this study, 26 had acute myocardial infarctions by traditional criteria. The ratio of LD-1 to total LD had greater diagnostic value than did LD-1 alone. In 90% of patients with myocardial infarction this ratio was increased within 12 h of admission, and all had increased ratios within 24 h. The false-positive rate was less than 1%, and an increased LD-1/total LD ratio had a predictive value of 96% for myocardial infarction. These results suggest that LD-1 is useful in the diagnosis of myocardial infarction on the first day of hospitalization.

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