scholarly journals The vasculature: a therapeutic target in heart failure?

2021 ◽  
Author(s):  
Guillermo Luxán ◽  
Stefanie Dimmeler
Keyword(s):  
Heart Failure ◽  
Therapeutic Strategy ◽  
Vascular Inflammation ◽  
Experimental Models ◽  
Preserved Ejection Fraction ◽  
Therapeutic Approaches ◽  
Metabolic Signalling ◽  
Non Coding Rna ◽  
Treat Heart Failure ◽  
Induce Heart Failure

AbstractIt is well established that the vasculature plays a crucial role in maintaining oxygen and nutrients supply to the heart. Increasing evidence further suggests that the microcirculation has additional roles in supporting a healthy microenvironment. Heart failure is well known to be associated with changes and functional impairment of the microvasculature. The specific ablation of protective signals in endothelial cells in experimental models is sufficient to induce heart failure. Therefore, restoring a healthy endothelium and microcirculation may be a valuable therapeutic strategy to treat heart failure. This review article will summarize the current understanding of the vascular contribution to heart failure with reduced or preserved ejection fraction. Novel therapeutic approaches including next generation pro-angiogenic therapies and non-coding RNA therapeutics, as well as the targeting of metabolites or metabolic signalling, vascular inflammation and senescence will be discussed.

scholarly journals Therapeutic approaches in heart failure with preserved ejection fraction: past, present, and future

2020 ◽  
Vol 109 (9) ◽  
pp. 1079-1098 ◽  
Author(s):  
Jan Wintrich ◽  
Ingrid Kindermann ◽  
Christian Ukena ◽  
Simina Selejan ◽  
Christian Werner ◽  
...  
Keyword(s):  
Heart Failure ◽  
Ejection Fraction ◽  
Preserved Ejection Fraction ◽  
Therapeutic Approaches

scholarly journals Heart Failure Syndrome With Preserved Ejection Fraction Is a Metabolic Cluster of Non-resolving Inflammation in Obesity

2021 ◽  
Vol 8 ◽  
Author(s):  
Bochra Tourki ◽  
Ganesh V. Halade
Keyword(s):  
Heart Failure ◽  
Ejection Fraction ◽  
Clinical Signs ◽  
Signs And Symptoms ◽  
Experimental Models ◽  
Metabolic Dysfunction ◽  
Preserved Ejection Fraction ◽  
Base Of The Pyramid ◽  
Kidney Fibrosis ◽  
Number Of Patients

Heart failure with preserved ejection fraction (HFpEF) is an emerging disease with signs of nonresolving inflammation, endothelial dysfunction, and multiorgan defects. Moreover, based on the clinical signs and symptoms and the rise of the obesity epidemic, the number of patients developing HFpEF is increasing. From recent molecular and cellular studies, it becomes evident that HFpEF is not a single and homogenous disease but a cluster of heterogeneous pathophysiology with aging at the base of the pyramid. Obesity superimposed on aging drives the number of inflammatory pathways that intersect with metabolic dysfunction and suboptimal inflammation. Here, we compiled information on obesity-directed macrophage dysfunction that coincide with metabolic defects. Obesity-associated proinflammatory stimuli facilitates heart and interorgan inflammation in HFpEF. Furthermore, diversified mechanisms that drive heart failure urge the need of studying pervasive and unresolved inflammation in animal models to understand HFpEF. A broad and system-based approach will help to study major translational aspects of HFpEF, since no single animal model recapitulates all signs of differential HFpEF stages in the clinical setting. Here, we covered experimental models that target HFpEF and emphasized the advances observed with formyl peptide 2 (FPR2) receptor, a prime sensor that is important in inflammation-resolution signaling. Dysfunction of FPR2 led to the development of spontaneous obesity, impaired macrophage function, and triggered kidney fibrosis, providing evidence of multiorgan defects in HFpEF in an obesogenic aging experimental model.

scholarly journals Targeting Obesity and Diabetes to Treat Heart Failure with Preserved Ejection Fraction

2017 ◽  
Vol 8 ◽  
Author(s):  
Raffaele Altara ◽  
Mauro Giordano ◽  
Einar S. Nordén ◽  
Alessandro Cataliotti ◽  
Mazen Kurdi ◽  
...  
Keyword(s):  
Heart Failure ◽  
Ejection Fraction ◽  
Preserved Ejection Fraction ◽  
Obesity And Diabetes ◽  
Treat Heart Failure
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