scholarly journals Ischaemic heart disease in women: are there sex differences in pathophysiology and risk factors?: Position Paper from the Working Group on Coronary Pathophysiology and Microcirculation of the European Society of Cardiology

2010 ◽  
Vol 90 (1) ◽  
pp. 9-17 ◽  
Author(s):  
V. Vaccarino ◽  
L. Badimon ◽  
R. Corti ◽  
C. de Wit ◽  
M. Dorobantu ◽  
...  
2017 ◽  
Vol 38 (25) ◽  
pp. 1951-1958 ◽  
Author(s):  
Lina Badimon ◽  
Raffaele Bugiardini ◽  
Edina Cenko ◽  
Judit Cubedo ◽  
Maria Dorobantu ◽  
...  

2021 ◽  
Author(s):  
S Lecour ◽  
B C Du Pré ◽  
H E Bøtker ◽  
B J J M Brundel ◽  
A Daiber ◽  
...  

Abstract Circadian rhythms are internal regulatory processes controlled by molecular clocks present in essentially every mammalian organ that temporally regulate major physiological functions. In the cardiovascular system, the circadian clock governs heart rate, blood pressure, cardiac metabolism, contractility and coagulation. Recent experimental and clinical studies highlight the possible importance of circadian rhythms in the pathophysiology, outcome, or treatment success of cardiovascular disease, including ischaemic heart disease. Disturbances in circadian rhythms are associated with increased cardiovascular risk and worsen outcome. Therefore, it is important to consider circadian rhythms as a key research parameter to better understand cardiac physiology/pathology, and to improve the chances of translation and efficacy of cardiac therapies, including those for ischaemic heart disease. The aim of this Position Paper by the European Society of Cardiology Working Group Cellular Biology of the Heart is to highlight key aspects of circadian rhythms to consider for improvement of preclinical and translational studies related to ischaemic heart disease and cardioprotection. Applying these considerations to future studies may increase the potential for better translation of new treatments into successful clinical outcomes.


2017 ◽  
Vol 113 (6) ◽  
pp. 564-585 ◽  
Author(s):  
Derek J. Hausenloy ◽  
David Garcia-Dorado ◽  
Hans Erik Bøtker ◽  
Sean M. Davidson ◽  
James Downey ◽  
...  

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