302 IS 18F-FDG PET/CT PARAMETERS USEFUL IN PREDICTING PATHOLOGICAL RESPONSE TO NEOADJUVANT CHEMORADIOTHERAPY FOR ESOPHAGEAL CARCINOMA?

Abstract The 18F-fluorodeoxyglucose positron emission tomography (FDG-PET/CT) provides an ability to functionally evaluate metabolic activity improving patient selection for surgical treatment. The value of SUVmax, MTV and TLG from FDG PET/CT of primary tumor and lymph nodes in the setting of neoadjuvant chemoradiotherapy for esophageal cancer in predicting pathological response to neoadjuvant therapy is the aim of this study. Methods A retrospective cohort study was performed, assessing the correlation of SUVmax and volumetric parameters (MTV and TLG) of 18F-FDG PET/CT prior and post to neoadjuvant therapy for esophageal carcinoma with the pathological response as outcomes. Results One hundred and seventeen patients were included. The higher AUC values in predicting pathological complete response were obtained for the primary tumor, on post neoadjuvant therapy. These variables showed high sensibility, but low specificity (SUVmax: AUC: 0.71, 95% CI: 0.55–0.87; MTV: AUC: 0.7, 95% CI: 0.54–0.86; TLG: AUC 0.71, 95% CI: 0.55–0.87). Conclusion PET-Scan functionally evaluates metabolic activity, and the absolute values and changes of SUVmax and volumetric variables provide important information for pathological tumor response to neoadjuvant chemoradiotherapy.

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The role of MRI and 18F-FDG PET/CT with respect to evaluation of pathological response in the rectal cancer patients after neoadjuvant chemoradiotherapy

Indian Journal of Cancer ◽

10.4103/ijc.ijc_80_20 ◽

2021 ◽

Vol 0 (0) ◽

pp. 0

Author(s):

GulhanGuler Avcı ◽

IpekPinar Aral

Keyword(s):

Rectal Cancer ◽

Cancer Patients ◽

Fdg Pet ◽

Neoadjuvant Chemoradiotherapy ◽

Pathological Response ◽

Pet Ct ◽

18F Fdg ◽

Fdg Pet Ct

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160 SURVIVAL ANALYSIS OF 18F-FDG PET/CT QUANTITATIVE PARAMETERS MEASURED IN PRIMARY TUMOR AND SUSPICIOUS LYMPH NODES IN PATIENTS WITH ESOPHAGEAL CARCINOMA

Diseases of the Esophagus ◽

10.1093/dote/doaa087.28 ◽

2020 ◽

Vol 33 (Supplement_1) ◽

Author(s):

F Tustumi ◽

F Takeda ◽

P Duarte ◽

D Albenda ◽

R Sallum ◽

...

Keyword(s):

Esophageal Cancer ◽

Neoadjuvant Therapy ◽

Burden Of Disease ◽

Primary Tumor ◽

Fdg Pet ◽

Trimodal Therapy ◽

Pet Ct ◽

Medicine Physician ◽

18F Fdg ◽

Fdg Pet Ct

Abstract 18F-FDG PET/CT quantitative techniques have been described as prognostic indicators in esophageal cancer. Objective: To evaluate the prognostic value of the maximal Standardized Uptake Value (SUVmax), the Metabolic Tumor Value (MTV) and the Total Lesion Glycolysis (TLG) measured in the primary tumor and in the suspicious lymph node. Methods A cohort study was performed to assess the association of SUVmax, MTV and TLG measured prior and post to neoadjuvant therapy, as well as the variation of these values between the two studies, with overall survival (OS) in patients with esophageal cancer submitted to trimodal therapy. The quantitative techniques were applied in the primary tumor (PT) and in the suspicious nodes (LN) by a nuclear medicine physician. The OS rates were analysed. Before neoadjuvant therapy, 106 patients had PET/CT, and 39 patients had post neoadjuvant PET/CT exams. Results Before neoadjuvant period all the variables related to LN were able to predict OS. MTV of primary (HR: 1.89; 95%CI: 1.01–3.52) tumor were also able to predict OS. On post neoadjuvant period and the variation pre-to-post neoadjuvant periods, none of the PET/CT variables related to LN were related to prognosis. All primary tumor volumetric variables were related to OS. MTV (HR: 4.66; 95%CI: 1.54–14.08) and TLG (HR: 4.86; 95%CI: 1.66–14.26) of PT of post neoadjuvant period; and the variation of MTV (HR: 2.95; 95%CI: 1.01–3.52) and TLG (HR: 3.49; 95%CI: 1.01–3.52) of the PT pre-to-post neoadjuvant periods were prognostic variables. Conclusion In patients with esophageal cancer, the burden of disease in the suspicious nodes and primary tumor prior to therapy and the residual burden of disease in PT in post therapy 18F-FDG PET/CT were associated with dismal prognosis.

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Baseline 18F-FDG PET/CT as predictor of the pathological response to neoadjuvant therapy in esophageal cancer

Medicine ◽

10.1097/md.0000000000013412 ◽

2018 ◽

Vol 97 (49) ◽

pp. e13412 ◽

Cited By ~ 2

Author(s):

Liran Domachevsky ◽

Hanoch Kashtan ◽

Baruch Brenner ◽

Meital Nidam ◽

Sara Morgenstern ◽

...

Keyword(s):

Esophageal Cancer ◽

Neoadjuvant Therapy ◽

Fdg Pet ◽

Pathological Response ◽

Pet Ct ◽

18F Fdg ◽

Fdg Pet Ct

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Metabolic activity of visceral fat and immune-related organs evaluated by 18F-FDG PET/CT is associated with the metabolic syndrome

European Heart Journal ◽

10.1093/ehjci/ehaa946.3051 ◽

2020 ◽

Vol 41 (Supplement_2) ◽

Author(s):

K Pahk ◽

H.W Kwon ◽

J.S Eo ◽

H.S Seo ◽

S Kim

Keyword(s):

Metabolic Syndrome ◽

Systemic Inflammation ◽

Metabolic Activity ◽

Fdg Pet ◽

Inflammatory Activity ◽

The Metabolic Syndrome ◽

Inflammatory Status ◽

Pet Ct ◽

18F Fdg ◽

Fdg Pet Ct

Abstract Background The risk of cardiovascular disease (CVD) is elevated in metabolic syndrome (MS) and is related to the inflammatory activity of visceral adipose tissue (VAT). We investigated whether the metabolic activity in VAT, assessed by 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT), is associated with systemic inflammatory status, and related to the number of MS components. Methods 18F-FDG PET/CT was performed in a total of 203 subjects: 59 without an MS component; M(0), 92 with one or two MS components; M(1–2), and 52 with MS. Metabolic activity of VAT was evaluated using the mean standardized uptake value (SUVmean) and the maximum SUV (SUVmax). Metabolic activities of immune-related organs such as spleen and bone marrow (BM) were evaluated using the SUVmax. Results VAT SUVmax correlated with high-sensitivity C-reactive protein (hsCRP) and the SUVmax of spleen and BM, which reflect the status of systemic inflammation. Both hsCRP and the SUVmax of the spleen and BM were higher in the MS group than in the M(1–2) or M(0) groups. In VAT, SUVmax increased with increasing number of MS components, while SUVmean decreased. Conclusions The SUVmax of VAT assessed by 18F-FDG PET/CT could reflect the inflammatory activity of VAT which is increased in the MS patients with systemic inflammation. Funding Acknowledgement Type of funding source: None

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