scholarly journals Donor pretreatment with adenosine monophosphate-activated protein kinase activator protects cardiac grafts from cold ischaemia/reperfusion injury

2015 ◽  
Vol 49 (5) ◽  
pp. 1354-1360 ◽  
Author(s):  
Chao Yang ◽  
Honglai Xu ◽  
Lanjun Cai ◽  
Xiaoxiao Du ◽  
Yinan Jiang ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Reperfusion Injury ◽  
Adenosine Monophosphate ◽  
Ischaemia Reperfusion Injury ◽  
Ischaemia Reperfusion ◽  
Donor Pretreatment

Mitochondrial protein kinase Cϵ (PKCϵ): emerging role in cardiac protection from ischaemic damage

2007 ◽  
Vol 35 (5) ◽  
pp. 1052-1054 ◽  
Author(s):  
G.R. Budas ◽  
D. Mochly-Rosen
Keyword(s):  
Protein Kinase ◽  
Reperfusion Injury ◽  
Mitochondrial Permeability Transition ◽  
Apoptotic Cell ◽  
Critical Role ◽  
Mitochondrial Protein ◽  
Permeability Transition ◽  
K Channel ◽  
Ischaemia Reperfusion Injury ◽  
Ischaemia Reperfusion

Mitochondria mediate diverse cellular functions including energy generation and ROS (reactive oxygen species) production and contribute to signal transduction. Mitochondria are also key regulators of cell viability and play a central role in necrotic and apoptotic cell death pathways induced by cardiac ischaemia/reperfusion injury. PKC (protein kinase C) ϵ plays a critical role in cardioprotective signalling pathways that protect the heart from ischaemia/reperfusion. Emerging evidence suggests that the cardioprotective target of PKCϵ resides at the mitochondria. Proposed mitochondrial targets of PKCϵ include mitoKATP (mitochondrial ATP-sensitive K+ channel), components of the MPTP (mitochondrial permeability transition pore) and components of the electron transport chain. This review highlights mitochondrial targets of PKCϵ and their possible role in cardioprotective signalling in the setting of ischaemia/reperfusion injury.

cGMP-dependent protein kinase mediates protection against ischaemia–reperfusion injury

2006 ◽  
Vol 40 (6) ◽  
pp. 961 ◽  
Author(s):  
Zoltán Giricz ◽  
Anikó Görbe ◽  
Dwaine S. Burley ◽  
Judit Pipis ◽  
Péter Ferdinandy ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Reperfusion Injury ◽  
Dependent Protein Kinase ◽  
Ischaemia Reperfusion Injury ◽  
Cgmp Dependent Protein Kinase ◽  
Ischaemia Reperfusion ◽  
Dependent Protein
Sign in / Sign up

Export Citation Format

Share Document