scholarly journals Exercise directly enhances myocardial tolerance to ischaemia-reperfusion injury in the rat through a protein kinase C mediated mechanism

Heart ◽  
2001 ◽  
Vol 85 (3) ◽  
pp. 331-336 ◽  
Author(s):  
N Yamashita
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Reperfusion Injury ◽  
Ischaemia Reperfusion Injury ◽  
Kinase C ◽  
Ischaemia Reperfusion

scholarly journals Inhibition of δ-Protein Kinase C Protects Against Reperfusion Injury of the Ischemic Heart In Vivo

Circulation ◽  
2003 ◽  
Vol 108 (19) ◽  
pp. 2304-2307 ◽  
Author(s):  
Koichi Inagaki ◽  
Leon Chen ◽  
Fumiaki Ikeno ◽  
Felix H. Lee ◽  
Ken-ichi Imahashi ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Reperfusion Injury ◽  
Ischemic Heart ◽  
Kinase C

Mitochondrial protein kinase Cϵ (PKCϵ): emerging role in cardiac protection from ischaemic damage

2007 ◽  
Vol 35 (5) ◽  
pp. 1052-1054 ◽  
Author(s):  
G.R. Budas ◽  
D. Mochly-Rosen
Keyword(s):  
Protein Kinase ◽  
Reperfusion Injury ◽  
Mitochondrial Permeability Transition ◽  
Apoptotic Cell ◽  
Critical Role ◽  
Mitochondrial Protein ◽  
Permeability Transition ◽  
K Channel ◽  
Ischaemia Reperfusion Injury ◽  
Ischaemia Reperfusion

Mitochondria mediate diverse cellular functions including energy generation and ROS (reactive oxygen species) production and contribute to signal transduction. Mitochondria are also key regulators of cell viability and play a central role in necrotic and apoptotic cell death pathways induced by cardiac ischaemia/reperfusion injury. PKC (protein kinase C) ϵ plays a critical role in cardioprotective signalling pathways that protect the heart from ischaemia/reperfusion. Emerging evidence suggests that the cardioprotective target of PKCϵ resides at the mitochondria. Proposed mitochondrial targets of PKCϵ include mitoKATP (mitochondrial ATP-sensitive K+ channel), components of the MPTP (mitochondrial permeability transition pore) and components of the electron transport chain. This review highlights mitochondrial targets of PKCϵ and their possible role in cardioprotective signalling in the setting of ischaemia/reperfusion injury.

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