scholarly journals Five-year results of intracoronary infusion of the mobilized peripheral blood stem cells by granulocyte colony-stimulating factor in patients with myocardial infarction

2012 ◽  
Vol 33 (24) ◽  
pp. 3062-3069 ◽  
Author(s):  
Hyun-Jae Kang ◽  
Min-Kyung Kim ◽  
Hae-Young Lee ◽  
Kyung-Woo Park ◽  
Whal Lee ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Stem Cells ◽  
Peripheral Blood ◽  
Granulocyte Colony Stimulating Factor ◽  
Colony Stimulating Factor ◽  
Peripheral Blood Stem Cells ◽  
Intracoronary Infusion ◽  
Blood Stem Cells ◽  
Stimulating Factor ◽  
Mobilized Peripheral Blood

Novel Use of Intraarticular Granulocyte Colony Stimulating Factor (hG-CSF) Combined with Activated Autologous Peripheral Blood Stem Cells Mobilized with Systemic hG-CSF: Safe and Efficient in Early Osteoarthritis

Cartilage ◽  
2021 ◽  
pp. 194760352110495
Author(s):  
Konstantinos I. Papadopoulos ◽  
Mantana Paisan ◽  
Warachaya Sutheesophon ◽  
Thana Turajane
Keyword(s):  
Stem Cells ◽  
Peripheral Blood ◽  
Granulocyte Colony Stimulating Factor ◽  
Older Individuals ◽  
Colony Stimulating Factor ◽  
Early Osteoarthritis ◽  
Peripheral Blood Stem Cells ◽  
Pharmacological Interactions ◽  
Blood Stem Cells ◽  
Stimulating Factor

Osteoarthritis (OA) tends to occur in older individuals frequently burdened with comorbidities and diverse pharmacological interactions. As articular cartilage has low regenerative power, potent local tissue engineering approaches are needed to support chondrogenic differentiation. Acellular preparation methods as well as approaches to coax endogenous reparative cells into the joint space appear to have limited success. Supported by our in-vitro and clinical studies, we propose that our novel intra-articular administration of human granulocyte colony stimulating factor (IA-hG-CSF) combined with autologous activated peripheral blood stem cells (AAPBSC) is safe and offers treatment advantages not seen with other cellular interventions in early osteoarthritis.

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