scholarly journals P3741Oxidation- and CaMKII-mediated sarcoplasmic reticulum Ca2+ leak drives the right ventricular dysfunction in pulmonary hypertension

2018 ◽  
Vol 39 (suppl_1) ◽  
Author(s):  
X Guo ◽  
L Yan ◽  
C X Lei ◽  
Y F Huang
Keyword(s):  
Pulmonary Hypertension ◽  
Sarcoplasmic Reticulum ◽  
Right Ventricular ◽  
Ventricular Dysfunction ◽  
Right Ventricular Dysfunction ◽  
The Right

scholarly journals Carfilzomib-induced pulmonary hypertension with associated right ventricular dysfunction: A case report

2021 ◽  
Vol 9 ◽  
pp. 2050313X2199403
Author(s):  
Pei-Chun McGregor ◽  
Valia Boosalis ◽  
Jayashri Aragam
Keyword(s):  
Multiple Myeloma ◽  
Pulmonary Hypertension ◽  
Right Ventricular ◽  
Ventricular Dysfunction ◽  
Right Ventricular Dysfunction ◽  
Left Ventricular ◽  
Elderly Male ◽  
Acute Right Ventricular Failure ◽  
The Right ◽  
Male Veteran

Carfilzomib, a selective proteasome inhibitor, is approved for use in relapsed and refractory multiple myeloma. Its link to left ventricular dysfunction is well established but little is known about its effects on the right ventricle. One of its rare complications is pulmonary hypertension, which at its extreme may result in right ventricular dysfunction. Here, we present a case of an elderly male veteran with multiple myeloma status post various failed therapies who developed acute dyspnea after four cycles of carfilzomib and subsequently found to have severe pulmonary hypertension with resultant acute right ventricular failure, which recovered after cessation of carfilzomib. This case highlights the need for careful cardiovascular surveillance while on carfilzomib and the importance of knowing even its rarest complications as these cardiotoxicities are reversible with discontinuation of the drug.

The strain-encoded (SENC) MR imaging for detection of global right ventricular dysfunction in pulmonary hypertension

2012 ◽  
Vol 29 (2) ◽  
pp. 371-378 ◽  
Author(s):  
Noriko Oyama-Manabe ◽  
Takahiro Sato ◽  
Ichizo Tsujino ◽  
Kohsuke Kudo ◽  
Osamu Manabe ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
Mr Imaging ◽  
Right Ventricular ◽  
Ventricular Dysfunction ◽  
Right Ventricular Dysfunction
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