Social determinants of systemic inflammation over the life course: a multi-cohort study

2018 ◽  
Vol 28 (suppl_4) ◽  
Author(s):  
E Berger ◽  
R Castagné ◽  
M Kivimäki ◽  
V Krogh ◽  
A Steptoe ◽  
...  
2018 ◽  
Vol 2018 (1) ◽  
Author(s):  
Eloïse Berger ◽  
Raphaële Castagné ◽  
Murielle Bochud ◽  
Marc Chadeau-Hyam ◽  
Angelo d'Errico ◽  
...  

2019 ◽  
Vol 10 (1) ◽  
Author(s):  
Eloïse Berger ◽  
Raphaële Castagné ◽  
Marc Chadeau-Hyam ◽  
Murielle Bochud ◽  
Angelo d’Errico ◽  
...  

2018 ◽  
Vol 28 (suppl_4) ◽  
Author(s):  
E Berger ◽  
R Castagné ◽  
M Kivimäki ◽  
V Krogh ◽  
A Steptoe ◽  
...  

2021 ◽  
pp. 103919
Author(s):  
Olliver SJ ◽  
Broadbent JM ◽  
Sabarinath Prasad ◽  
Celene Cai ◽  
W. Murray Thomson ◽  
...  

2020 ◽  
Author(s):  
Linda M. O’Keeffe ◽  
Joshua A. Bell ◽  
Kate N. O’Neill ◽  
Matthew Lee ◽  
Mark Woodward ◽  
...  

AbstractBackgroundSex differences in cardiometabolic disease risk are commonly observed across the life course but are poorly understood and may be due to different cardiometabolic consequences of adiposity in females and males. We examined whether adiposity influences cardiometabolic trait levels differently in females and males at four different life stages.MethodsData were from two generations (offspring, Generation 1 [G1] and their parents, Generation 0 [G0]) of the Avon Longitudinal Study of Parents and Children birth cohort study. Body mass index (BMI) and total fat mass from dual-energy x-ray absorptiometry were measured at mean age 9y, 15y and 18y in G1. Waist circumference was measured at 9y and 15y in G1. Concentrations of 148 cardiometabolic traits quantified using nuclear magnetic resonance spectroscopy were measured at 15y, 18y and 25y in G1. In G0, all three adiposity measures and the same 148 traits were available at 50y.Using linear regression models, sex-specific associations of adiposity measures at each time point (9y, 15y and 18y) with cardiometabolic traits 3 to 6 years later were examined in G1. In G0, sex-specific associations of adiposity measures and cardiometabolic traits were examined cross- sectionally at 50y.Results3081 G1 and 4887 G0 participants contributed to analyses. BMI was more strongly associated with key atherogenic traits in males at younger ages (15y-25y) and associations were more similar between the sexes or stronger in females at 50y, particularly for apolipoprotein-B-containing lipoprotein particles and lipid concentrations. For example, a 1- SD (3.8 kg/m2) higher BMI at 18y was associated with 0.36 SD (95% Confidence Interval (CI) = 0.20, 0.52) higher concentrations of extremely large very-low-density lipoprotein (VLDL) particles at 25y in males compared with 0.15 SD (95% CI = 0.09, 0.21) in females. In contrast, at 50y, a 1-SD (4.8 kg/m2) higher BMI was associated with 0.33 SD (95% CI = 0.25, 0.42) and 0.30 SD (95% CI = 0.26, 0.33) higher concentrations of extremely large VLDL particles in males and females respectively. Sex-specific associations of DXA-measured fat mass and waist circumference were similar to findings for BMI in both generations and at all ages.ConclusionThe results of this study suggest that the adverse cardiometabolic effects of adiposity are stronger and begin earlier in the life course among males compared with females until mid life, particularly for key atherogenic lipids. Adolescent and young adult males may therefore be high priority targets for obesity prevention efforts.


2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. 81-81
Author(s):  
Jean-Francois Trani

Abstract Structural and social determinants of health differentially impact on social groups. Among those particularly disadvantaged during the life course are both persons with disabilities and refugees. Because of the way society treats these two populations, both persons with disabilities and refugees may face physical, social, economic and environmental barriers that impede them from benefiting from the same opportunities accessible to other social groups. As a result, these populations have less access to education, higher unemployment, are more likely to be deprived and excluded from social benefits. In other words, public stigma —prejudice and discrimination voiced and practiced by the general population— translates to a life course characterized by daily stressors that result in a higher likelihood of cognitive disorders and dementia. Measuring and analyzing SSDoH inclusive of disability and refugee experiences are essential to efforts aimed at recruitment and retention and knowledge generation in ADRD research.


2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S393-S393
Author(s):  
Jacquelyn Minahan ◽  
Tamara A Baker

Abstract Social determinants of health (SDoH) are conditions in which individuals live, learn, work, and play. Specifically, they are influenced by the distribution of resources, money, and power, and have significant implications on health behaviors and outcomes across the life span. Existent data show the influence these indictors may have in the onset and progression of chronic illnesses. However, much of these data focus on the effect of race and health, as social determinants, but fail to adequately address the myriad other factors (e.g., health care, social and community context) that influence the social patterning across the life course. This symposium presents findings from several studies highlighting the nuanced role of SDoH across diverse populations of older adults. Scholars will present findings on the influence that identified determinants, such as social networks, lifestyle behaviors, and gender, have in defining health outcomes across the life course. Minahan presents the relationship between chronic illnesses and depression and compares depressive symptomatology according to disease cluster in a nationally-representative sample of older adults. Atakere discusses determinants of well-being among African American males with chronic illnesses and the challenges associated with this marginalized population. Booker examines spirituality as a mechanism for pain management among older African Americans and presents this as a crucial determinant of health. This symposium will expand on the existing body of literature by emphasizing social and cultural determinants, aside from race, that influence health behaviors and outcomes across the life span.


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