scholarly journals Genetic engineering of Ehrlich pathway modulates production of higher alcohols in engineered Yarrowia lipolytica

2018 ◽  
Vol 19 (2) ◽  
Author(s):  
Ewelina Celińska ◽  
Monika Borkowska ◽  
Wojciech Białas ◽  
Monika Kubiak ◽  
Paulina Korpys ◽  
...  
Keyword(s):  
Genetic Engineering ◽  
Yarrowia Lipolytica ◽  
Higher Alcohols ◽  
Ehrlich Pathway

scholarly journals Refactoring Ehrlich Pathway for High-Yield 2-Phenylethanol Production in Yarrowia lipolytica

2020 ◽  
Vol 9 (3) ◽  
pp. 623-633 ◽  
Author(s):  
Yang Gu ◽  
Jingbo Ma ◽  
Yonglian Zhu ◽  
Peng Xu
Keyword(s):  
Yarrowia Lipolytica ◽  
High Yield ◽  
Ehrlich Pathway

scholarly journals Genetic engineering of Yarrowia lipolytica for enhanced production of trans-10, cis-12 conjugated linoleic acid

2013 ◽  
Vol 12 (1) ◽  
pp. 70 ◽  
Author(s):  
Baixi Zhang ◽  
Haiqin Chen ◽  
Min Li ◽  
Zhennan Gu ◽  
Yuanda Song ◽  
...  
Keyword(s):  
Linoleic Acid ◽  
Genetic Engineering ◽  
Conjugated Linoleic Acid ◽  
Yarrowia Lipolytica ◽  
Enhanced Production

Genetic engineering to enhance the Ehrlich pathway and alter carbon flux for increased isobutanol production from glucose by Saccharomyces cerevisiae

2012 ◽  
Vol 159 (1-2) ◽  
pp. 32-37 ◽  
Author(s):  
Takashi Kondo ◽  
Hironori Tezuka ◽  
Jun Ishii ◽  
Fumio Matsuda ◽  
Chiaki Ogino ◽  
...  
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Genetic Engineering ◽  
Carbon Flux ◽  
Ehrlich Pathway

Thiaminpyrophosphat – ein natürlich vorkommendes Iminium-Salz. Seine Bedeutung für die mikrobiellen Prozesse bei der Weinbereitung und die Aromabildung im Wein / Thiamine Diphosphate – A Natural Iminium Salt. Its Role in Microbiological Processes During Wine Preparation and on the Aroma of Wine

2014 ◽  
Vol 69 (5) ◽  
pp. 489-500 ◽  
Author(s):  
Nikolaus Müller
Keyword(s):  
Amino Acids ◽  
Enzymatic Degradation ◽  
Malolactic Fermentation ◽  
Alcoholic Beverages ◽  
Higher Alcohols ◽  
Thiamine Diphosphate ◽  
Ehrlich Pathway ◽  
Biochemical Processes ◽  
Microbiological Processes ◽  
Iminium Salt

Iminium salt structures are widespread in nature and play an important role in biochemical processes. Among these thiamine diphosphate (ThPP, Vitamine B1) is one of the best known examples. It serves as a cofactor in a variety of different enzymes that are found in all forms of life. During fermentation for the production of alcoholic beverages, ThPP is of great importance not only for the key step (decarboxylation of pyruvate), but also for the formation of secondary metabolites which highly influence the aroma of wine. Thus, enzymatic degradation of amino acids in yeasts via the Ehrlich pathway delivers higher alcohols, fatty acids and esters. In malolactic fermentation, ThPPdependant enzymes (ligases) form new C-C bonds to synthezise the highly aroma-active substance diacetyl. This article summarizes the influence of ThPP on the sensorically important substances during wine making processes.

scholarly journals Metabolic Engineering for Unusual Lipid Production in Yarrowia lipolytica

2020 ◽  
Vol 8 (12) ◽  
pp. 1937
Author(s):  
Young-Kyoung Park ◽  
Jean-Marc Nicaud
Keyword(s):  
Fatty Acids ◽  
Metabolic Engineering ◽  
Genetic Engineering ◽  
Functional Groups ◽  
Yarrowia Lipolytica ◽  
Lipid Production ◽  
Lipid Synthesis ◽  
Alternative Method ◽  
Endogenous Lipid ◽  
Yeast Yarrowia Lipolytica

Using microorganisms as lipid-production factories holds promise as an alternative method for generating petroleum-based chemicals. The non-conventional yeast Yarrowia lipolytica is an excellent microbial chassis; for example, it can accumulate high levels of lipids and use a broad range of substrates. Furthermore, it is a species for which an array of efficient genetic engineering tools is available. To date, extensive work has been done to metabolically engineer Y. lipolytica to produce usual and unusual lipids. Unusual lipids are scarce in nature but have several useful applications. As a result, they are increasingly becoming the targets of metabolic engineering. Unusual lipids have distinct structures; they can be generated by engineering endogenous lipid synthesis or by introducing heterologous enzymes to alter the functional groups of fatty acids. In this review, we describe current metabolic engineering strategies for improving lipid production and highlight recent researches on unusual lipid production in Y. lipolytica.

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