Destabilization of Simple Repetitive DNA Sequences by Transcription in Yeast
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Abstract Simple repetitive DNA sequences in the eukaryotic genome frequently alter in length. In wild-type strains, we find that transcription through a repetitive poly GT tract destabilizes the tract four- to ninefold. In mismatch repair-deficient yeast strains, simple repeats are very unstable. High levels of transcription in such strains destabilize repetitive tracts an additional two- to threefold.
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2005 ◽
Vol 23
(2)
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pp. 235-239
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1983 ◽
Vol 80
(18)
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pp. 5641-5645
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1986 ◽
Vol 72
(2)
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pp. 207-210
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