scholarly journals Epidemiology of Peripheral Vascular Disease in the Long Life Family Study (LLFS)

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. 55-55
Author(s):  
Allison Kuipers ◽  
Ryan Cvejkus ◽  
Emma Barinas-Mitchell ◽  
Mary Feitosa ◽  
Joanne Murabito ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Vascular Disease ◽  
Peripheral Vascular Disease ◽  
Ankle Brachial Index ◽  
Posterior Tibial Artery ◽  
Epidemiologic Studies ◽  
Peripheral Vascular ◽  
Current Smoking ◽  
The Mean ◽  
Artery Disease

Abstract Atherosclerotic occlusion of peripheral arteries is a major contributor to morbidity and mortality in older adults. Our aim was to describe the epidemiology of peripheral artery disease (PAD) and other peripheral vascular disease (OPD) in the LLFS. 3248 individuals from 509 families (1182 probands, mean age 89; 2066 offspring, mean age 60) had doppler ankle-brachial index (ABI) assessment. Measures were performed twice for each posterior tibial artery and minimum of the mean ABI was used. PAD was defined as any ABI<0.9. OPD was defined as any ABI >1.4 or ≥1 non-compressible artery. Stepwise linear or logistic regression determined significant independent clinical and demographic predictors (P<0.05) after adjustment for age, sex, study center, and familial relatedness. Overall, ABI had a median of 1.2 with 7.4% PAD (18.1% probands, 1.2% offspring; P<0.001). OPD prevalence was 10.6% and was more common than PAD in offspring (8.1%). Age-adjusted OPD was higher in men (13.3%) than women (8.3%, P<0.001), while age-adjusted PAD did not did not differ by sex (P=0.45). Predictors of PAD included greater age and systolic blood pressure, lower diastolic blood pressure, prevalent kidney disease, antihypertensive use, and current smoking. Predictors of OPD included greater age, male sex, and current smoking. In these exceptionally long-lived families, PAD was low compared to other epidemiologic studies. However, OPD including non-compressible arteries, a marker of arterial stiffness, was more prevalent than PAD. These findings in long-lived families highlight a need for more epidemiologic research in other peripheral vascular disease in adults from the general population.

scholarly journals Prevalence of peripheral artery disease in diabetes mellitus: research article

2017 ◽  
Vol 5 (11) ◽  
pp. 4881
Author(s):  
Vinod Tyagi ◽  
Abhishek Gupta ◽  
Naman Bansal ◽  
S. K. Virmani
Keyword(s):  
Diabetes Mellitus ◽  
Vascular Disease ◽  
Peripheral Vascular Disease ◽  
Peripheral Artery Disease ◽  
Ankle Brachial Index ◽  
Ankle Brachial Pressure Index ◽  
Peripheral Vascular ◽  
Peripheral Artery ◽  
Pressure Index ◽  
Artery Disease

Background: Peripheral artery disease is a major macrovascular complication of diabetes mellitus. Patients with diabetes mellitus have an increased prevalence of PAD. The ankle brachial pressure index is an easy, non invasive and often under utilised tool for diagnosis of PAD.Methods: In the present study, 100 patients from Western Uttar Pradesh with diabetes mellitus were enrolled to find out prevalence of peripheral vascular disease using ankle brachial pressure index and study the associated risk factors.Results: 59 percent of the subjects were female and 41 percent were male. Ankle-brachial index (ABI) examination of patients indicated Abnormal (ABI= <0.9), in 40 cases.Conclusions: it can be concluded that peripheral vascular disease in Diabetes Mellitus is more commonly associated than is generally believed.

Surgical Therapy for Coronary Artery Disease Among Patients With Combined Coronary Artery and Peripheral Vascular Disease

Circulation ◽  
1995 ◽  
Vol 91 (1) ◽  
pp. 46-53 ◽  
Author(s):  
Charanjit S. Rihal ◽  
Kim A. Eagle ◽  
Mary C. Mickel ◽  
Eric D. Foster ◽  
George Sopko ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Vascular Disease ◽  
Peripheral Vascular Disease ◽  
Surgical Therapy ◽  
Peripheral Vascular ◽  
Artery Disease

Abstract 101: Gender Has Differential Effects on Non-Hemorrhagic Stroke Outcomes

2015 ◽  
Vol 8 (suppl_2) ◽  
Author(s):  
Justin Pieper ◽  
Michael Ashamalla ◽  
Daniel Sedhom ◽  
Neil Yager ◽  
Ketan Ghate ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Renal Insufficiency ◽  
Vascular Disease ◽  
Peripheral Vascular Disease ◽  
Hemorrhagic Stroke ◽  
Peripheral Vascular ◽  
Stroke Outcomes ◽  
History Of ◽  
Artery Disease

Background: We sought to examine the relationship between gender, age, co-morbidities, and outcomes in patients with non-hemorrhagic stroke. Materials and methods: Retrospective chart review was performed on 517 consecutive non-hemorrhagic stroke patients (48% women, 20% with diabetes, 26.8% with CAD, 38% with dyslipidemia, 62.2% with HTN, 4.2% with peripheral vascular disease, 4.7% with renal insufficiency) treated at a single academic medical center. Results: Younger patients were more likely to be men (age<50 55%, 51-60 58.3%, 61-70 59.6%; p<0.05) while older patients were likely to be women (age 71-80 54.9%, >80 56.6; p<0.05). Accordingly, the subsequent analysis stratified the cohort into two groups, <70 and >70 years old. Regardless of age, men had a higher prevalence of CAD (age <70, 25.2% vs 18.8% in women, and age >70, 43.7% vs. 23.1% in women; p<0.05) and dyslipidemia (age <70, 43.4% vs 32.5% in women and age >70, 44.8% vs. 30.6% in women; p=.05). There were no significant gender based differences in BMI, prevalence of diabetes, hypertension, peripheral vascular disease, or chronic renal insufficiency. The mean follow up duration was 47.3+/-0.9 months. Gender did not affect mortality in patients younger than 70 years old (15.5% men vs. 15.6% women.) However in patients of age >70 mortality was significantly increased in men (50.5% in men vs. 41.7% in women; chi-squared p<0.001, log-rank p<0.0001, Figure). In logistic regression analysis, when compared to women younger than 70 years old, men of the same age had similar mortality (HR 1.0; 95%CI 0.5-1.9, p=0.980); while age greater than 70 conferred 4-5 fold increased risk of mortality (HR 3.9; 95%CI 2.1-7.0, p<0.0001 in women, and HR 5.5; 95%CI 3.0-10.3, p<0.0001 in men). When gender and age were accounted for, history of coronary artery disease and/or dyslipidemia did not affect the outcomes. Conclusion: Men with non-hemorrhagic stroke were more likely to have dyslipidemia and history of coronary artery disease. This, however, did not translate into increased mortality in younger men. Gender appears to have a differential effect on non-hemorrhagic stroke outcomes which warrants future investigation.

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