scholarly journals Successful bilateral lung transplantation and simultaneous Nuss technique correction of pectus excavatum post-allogeneic haematopoietic stem cell transplantation

Author(s):  
Zhenrong Zhang ◽  
Hao Ding ◽  
Feng Liu ◽  
Jingyu Chen

Abstract Bronchiolitis obliterans syndrome after allogeneic haematopoietic stem cell transplantation has aroused clinical concern. We describe a case of a 39-year-old female patient diagnosed as bronchiolitis obliterans syndrome and concomitant pectus excavatum with a Haller index of 3.32. The patient received bilateral lung transplantation and simultaneously underwent Nuss surgery via bilateral anterolateral thoracotomies with veno-arterial extracorporeal membrane oxygenation support. The bar was removed 2 years after transplantation, and the patient has been stable in the past 4 years with haematological remission and satisfactory lung function.

2020 ◽  
Vol 29 (156) ◽  
pp. 190119
Author(s):  
Samran Haider ◽  
Navin Durairajan ◽  
Ayman O. Soubani

Haematopoietic stem cell transplantation (HSCT) is an established treatment for a variety of malignant and nonmalignant conditions. Pulmonary complications, both infectious and noninfectious, are a major cause of morbidity and mortality in patients who undergo HSCT. Recent advances in prophylaxis and treatment of infectious complications has increased the significance of noninfectious pulmonary conditions. Acute lung injury associated with idiopathic pneumonia syndrome remains a major acute complication with high morbidity and mortality. On the other hand, bronchiolitis obliterans syndrome is the most challenging chronic pulmonary complication facing clinicians who are taking care of allogeneic HSCT recipients. Other noninfectious pulmonary complications following HSCT are less frequent. This review provides a clinical update of the incidence, risk factors, pathogenesis, clinical characteristics and management of the main noninfectious pulmonary complications following HSCT.


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