Interim Report of a Controlled Field Trial of Immunization with Capsular Polysaccharides of Haemophilus influenzae Type band Group C Neisseria meningitidis in Mecklenburg County, North Carolina (March 1974-March 1976)

1977 ◽  
Vol 136 (Supplement 1) ◽  
pp. S51-S56 ◽  
Author(s):  
J. C. Parke ◽  
R. Schneerson ◽  
J. B. Robbins ◽  
J. J. Schlesselman
Keyword(s):  
North Carolina ◽  
Haemophilus Influenzae ◽  
Neisseria Meningitidis ◽  
Field Trial ◽  
Haemophilus Influenzae Type ◽  
Capsular Polysaccharides ◽  
Interim Report ◽  
Mecklenburg County ◽  
Type Band ◽  
Band Group

Polysaccharide Vaccines of Group A Neisseria meningitidis and Haemophilus influenzae Type b: A Field Trial in Finland

1977 ◽  
Vol 136 (Supplement 1) ◽  
pp. S43-S50 ◽  
Author(s):  
P. Helena Makela ◽  
H. Peltola ◽  
H. Kayhty, ◽  
H. Jousimies ◽  
O. Pettay ◽  
...  
Keyword(s):  
Haemophilus Influenzae ◽  
Neisseria Meningitidis ◽  
Field Trial ◽  
Haemophilus Influenzae Type ◽  
Haemophilus Influenzae Type B ◽  
Type B ◽  
Group A

Immunogenicity of Haemophilus influenzae Type b Polysaccharide-Neisseria meningitidis Outer Membrane Protein Conjugate Vaccine in 2- to 6-Month-Old Infants

PEDIATRICS ◽  
1987 ◽  
Vol 80 (2) ◽  
pp. 283-287
Author(s):  
Allen A. Lenoir ◽  
Paul D. Granoff ◽  
Dan M. Granoff
Keyword(s):  
Membrane Protein ◽  
Haemophilus Influenzae ◽  
Neisseria Meningitidis ◽  
Outer Membrane Protein ◽  
Geometric Mean ◽  
Serum Antibody ◽  
Haemophilus Influenzae Type ◽  
Antibody Concentration ◽  
Haemophilus Influenzae Type B ◽  
Type B

Fifty infants, 2 to 6 months of age, were vaccinated with Haemophilus influenzae type b capsular polysaccharide covalently linked to an outer membrane protein from Neisseria meningitidis group B. Subjects were given two injections and were randomly assigned to receive the injections separated by 1 or 2 months. Each dose contained 15 µg of polysaccharide and 51 µg of protein, or approximately twice the amount of polysaccharide as used in our previous trial (Lancet 1986;2:299). Fevers of 38.0° to 38.8°C developed in three infants (6%) within 24 hours after vaccination, but there were no other notable reactions. Following one injection, the geometric mean antibody concentration increased from 0.13 µg/mL in preimmune serum to 1.50 µg/mL in serum obtained 1 to 2 months later (P < .001). After a second injection, there was a further increase in serum antibody (geometric mean = 3.11 µg/mL, P < .007). The geometric mean antibody concentration of the group reimmunized 2 months after the first injection was higher than that in the group reimmunized after 1 month (3.95 v 2.32 µg/mL, P = .05, by analysis of covariance with age as the covariant). These data confirm our previous preliminary observations on the safety and immunogenicity of this new conjugate vaccine in infants 2 to 6 months of age. The data suggest that a 2-month interval between the first and second injections results in higher levels of serum antibody than a 1-month interval.

In Vitro Activation of Human T Lymphocytes by Haemophilus influenzae Type b Capsular Polysaccharides

1992 ◽  
Vol 35 (2) ◽  
pp. 137-148 ◽  
Author(s):  
C. C. A. M. PEETERS ◽  
A.-M. TENBERGEN-MEEKES ◽  
C. J. HEIJNEN ◽  
J. T. POOLMAN ◽  
B. J. M. ZEGERS ◽  
...  
Keyword(s):  
T Lymphocytes ◽  
Haemophilus Influenzae ◽  
Haemophilus Influenzae Type ◽  
Haemophilus Influenzae Type B ◽  
Capsular Polysaccharides ◽  
Type B ◽  
Human T Lymphocytes ◽  
In Vitro Activation

Vaccination responses to Neisseria meningitidis and Haemophilus influenzae type b in two C2-deficient sisters

2000 ◽  
Vol 49 (1-2) ◽  
pp. 74
Author(s):  
Barbro Selander ◽  
Helena Käyhty ◽  
Elisabeth Wedege ◽  
Eva Holmström ◽  
Lennart Truedsson ◽  
...  
Keyword(s):  
Haemophilus Influenzae ◽  
Neisseria Meningitidis ◽  
Haemophilus Influenzae Type ◽  
Haemophilus Influenzae Type B ◽  
Type B
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